MaAsLin 3 Tutorial

Introduction

MaAsLin 3 is the next generation of MaAsLin (Microbiome Multivariable Association with Linear Models).

MaAsLin3 is comprehensive R package for efficiently determining multivariable associations between clinical metadata and microbial meta-omics features. Relative to MaAsLin 2, MaAsLin 3 introduces the ability to quantify and test for both abundance and prevalence associations while accounting for compositionality. MaAsLin3 relies on general linear models to accommodate most modern epidemiological study designs, including cross-sectional and longitudinal, along with a variety of filtering, normalization, and transform methods.

If you use the MaAsLin 3 software, please cite our manuscript:

William A. Nickols, Jacob T. Nearing, Kelsey N. Thompson, Jiaxian Shen, Curtis Huttenhower MaAsLin 3: Refining and extending generalized multivariate linear models for meta-omic association discovery. (In progress).

Support

If you have questions, please direct it to: MaAsLin 3 Forum .

1. Installing R
2. Installing MaAsLin 3
3. Microbiome Association Detection with MaAsLin 3
4. Advanced Topics
5. Command Line Interface

1. Installing R

R is a programming language specializing in statistical computing and graphics. You can use R just the same as any other programming languages, but it is most useful for statistical analyses, with well-established packages for common tasks such as linear modeling, ’omic data analysis, machine learning, and visualization. We have created a short introduction tutorial here, but we note there are many other more comprehensive tutorials out there to learn R.

Installing R for the first time

You can download and install the free R software environment here. Note that you should download the latest release - this will ensure the R version you have is compatible with MaAsLin 3.

(Optional) the RStudio IDE

RStudio is a freely available IDE (integrated development environment) for R. It is a “wrapper” around R with some additional functionalities that makes programming in R a bit easier. Feel free to download RStudio and explore its interface - but it is not required for this tutorial.

Important: the correct R version

If you already have R installed, then it is possible that the R version you have does not support MaAsLin 3. The easiest way to check this is to launch R/RStudio, and in the console (“Console” pane in RStudio), type in the following command (without the > symbol):

sessionInfo()

The first line of output message should indicate your current R version. For example:

> sessionInfo()
R version 4.4.1 (2024-06-14)

For MaAsLin 3 to install, you will need R >= 4.3. If your version is older than that, please refer to section Installing R for the first time to download the latest R. Note that RStudio users will need to have RStudio “switch” to this later version once it is installed. This should happen automatically for Windows and Mac OS users when you relaunch RStudio. For Linux users you might need to bind the correct R executable. For more information refer to here. Either way, once you have the correct version installed, launch the software and use sessionInfo() to make sure that you indeed have R >= 4.3.

2. Installing MaAsLin 3

The latest development version of MaAsLin 3 can be installed from GitHub using the devtools package.

if (!require('devtools', character.only = TRUE)) {
  install.packages('devtools')
}

library("devtools")
install_github("biobakery/MaAsLin3")

for (lib in c('maaslin3', 'dplyr', 'ggplot2', 'knitr', 'kableExtra')) {
    suppressPackageStartupMessages(require(lib, character.only = TRUE))
}

3. Microbiome Association Detection with MaAsLin 3

To run MaAsLin 3, a user inputs a table of per-sample feature abundances (with zeros still included), a table of per-sample metadata, and a model specifying how the metadata should relate to the feature presence/absence and abundance. MaAsLin 3 will return a table of associations including an effect size and p-value for each feature-metadatum association and a folder of visuals including a summary plot and diagnostic plots for significant associations.

3.1 MaAsLin 3 Input

MaAsLin3 requires two input files.

Feature abundance data frame
- Formatted with features as columns and samples as rows.
- The transpose of this format is also okay.
- Possible features in this file include taxonomy or genes. These can be relative abundances or counts.
- This can be a filepath to a tab-delimited file.
Metadata data frame
- Formatted with variables as columns and samples as rows.
- The transpose of this format is also okay.
- Possible metadata in this file include gender or age.
- This can be a filepath to a tab-delimited file.

The data file can contain samples not included in the metadata file (along with the reverse case). For both cases, those samples not included in both files will be removed from the analysis. Also the samples do not need to be in the same order in the two files.

Example input files can be found in the inst/extdata folder of the MaAsLin 3 source. The files provided were generated from the HMP2 data which can be downloaded from https://ibdmdb.org/ .

# Read abundance table
taxa_table_name <- system.file("extdata", "HMP2_taxonomy.tsv", package = "maaslin3")
taxa_table <- read.csv(taxa_table_name, sep = '\t')

# Read metadata table
metadata_name <- system.file("extdata", "HMP2_metadata.tsv", package = "maaslin3")
metadata <- read.csv(metadata_name, sep = '\t')

# Factor the categorical variables to test against controls
metadata$diagnosis <- 
  factor(metadata$diagnosis, levels = c('nonIBD', 'UC', 'CD'))
metadata$dysbiosis_state <- 
  factor(metadata$dysbiosis_state, levels = c('none', 'dysbiosis_UC', 'dysbiosis_CD'))
metadata$antibiotics <- 
  factor(metadata$antibiotics, levels = c('No', 'Yes'))

taxa_table[1:5, 1:5]

##            Phocaeicola_vulgatus Faecalibacterium_prausnitzii
## CSM5FZ3N_P            0.4265226                  0.060255109
## CSM5FZ3R_P            0.5369584                  0.007396904
## CSM5FZ3T_P            0.5911821                  0.000000000
## CSM5FZ3V_P            0.2661378                  0.029680329
## CSM5FZ3X_P            0.6601039                  0.003596740
##            Bacteroides_uniformis Prevotella_copri_clade_A Bacteroides_stercoris
## CSM5FZ3N_P          0.2692411314             0.000000e+00           0.000000000
## CSM5FZ3R_P          0.2526048469             0.000000e+00           0.008390958
## CSM5FZ3T_P          0.0000000000             0.000000e+00           0.000000000
## CSM5FZ3V_P          0.4004265260             0.000000e+00           0.000000000
## CSM5FZ3X_P          0.0008804283             1.308102e-05           0.001335669

metadata[1:5, 1:5]

##            participant_id    site_name week_num    reads diagnosis
## CSM5FZ3N_P          C3001 Cedars-Sinai        0  9961743        CD
## CSM5FZ3R_P          C3001 Cedars-Sinai        2 16456391        CD
## CSM5FZ3T_P          C3002 Cedars-Sinai        0 10511448        CD
## CSM5FZ3V_P          C3001 Cedars-Sinai        6 17808965        CD
## CSM5FZ3X_P          C3002 Cedars-Sinai        2 13160893        CD

HMP2_taxonomy.tsv: is a tab-delimited file with samples as rows and species as columns. It is a subset of the taxonomy file that includes just some of the the species abundances.

HMP2_metadata.tsv: is a tab-delimited file with samples as rows and metadata as columns. It is a subset of the metadata file that includes just some of the fields.

3.2 Running MaAsLin 3

MaAsLin 3 is run by specifying a param_list that contains the abundance table (input_data), the metadata table (input_metadata), the output directory (output), and a model specification. The model specification can come from a formula or vectors of terms. In either case, variable names should not have spaces or unusual characters.

Formula: The formula parameter should be set to any formula that satisfies the lme4 specifications: fixed effects, interaction terms, random effects, polynomial terms, and more can all be included. In addition, group and ordered predictors (see below) can be included by including group(variable_name) and ordered(variable_name) in the formula.
Vectors: Alternatively, a vector of variables can be supplied to the parameters fixed_effects, random_effects, group_effects, and ordered_effects. Categorical variables should either be ordered as factors beforehand, or reference should be provided as a string of ‘variable,reference’ semi-colon delimited for multiple variables (e.g., variable_1,reference_1;variable_2,reference_2). NOTE: adding a space between the variable and level might result in the wrong reference level being used.

Because MaAsLin 3 considers prevalence associations, read depth (number of reads) should be included as a covariate if available since deeper sequencing will likely increase feature detection in a way that could spuriously correlate with metadata of interest.

Running MaAsLin 3 on HMP2 data

The following command runs MaAsLin 3 on the HMP2 data, running a multivariable regression model to test for the association between microbial species abundance and prevalence versus IBD diagnosis and dysbiosis scores while controlling for antibiotic usage, age, and the sampling depth (reads). Outputs are generated in a folder called demo_output under the current working directory (output = "demo_output").

To show one of each type of plot (see below), the maximum number of significant associations to plot has been increased with max_pngs=100. All other parameters beyond the first four are the default parameters but are still included for clarity. By default, total sum scaling with a log transformation afterwards will be used. However, other normalizations and transformations are allowed (see normalization and transform in the manual). Also by default, a data augmentation procedure is used to avoid linear separability in the logistic regressions. This is almost always recommended, though it can be turned off (see augment in the manual). A nominal FDR level of 0.1 determines which associations are significant, but this can also be changed (see max_significance in the manual). For the abundance coefficients, to account for compositionality in relative abundance data, significance is determined by comparing against the median coefficient for a metadatum across the features (median_comparison_abundance). Since prevalence coefficients do not have the same compositional properties, they are instead compared against 0 (median_comparison_prevalence). See the manual for a discussion of when to change these parameters. One CPU is used for fitting (cores = 1).

param_list <- list(input_data = taxa_table, 
                   input_metadata = metadata, 
                   output = 'demo_output', 
                   formula = '~ diagnosis + dysbiosis_state + antibiotics + age + reads',
                   normalization = 'TSS', 
                   transform = 'LOG', 
                   augment = TRUE, 
                   max_significance = 0.1, 
                   median_comparison_abundance = TRUE, 
                   median_comparison_prevalence = FALSE, 
                   max_pngs = 100,
                   cores = 1)

fit_out <- maaslin3(param_list)

Median comparisons

When median_comparison_abundance or median_comparison_prevalence are on, the coefficients for a metadatum will be tested against the median coefficient for that metadatum (median across the features). Otherwise, the coefficients will be tested against 0. For abundance associations, this is designed to account for compositionality, the idea that if only one feature has a positive association with a metadatum on the absolute scale, the other features will have apparent negative associations with that metadatum on the relative scale because relative abundances must sum to 1. More generally, associations on the relative scale are not necessarily the same as the associations on the absolute scale in magnitude or sign, so testing against zero on the relative scale is not equivalent to testing against zero on absolute scale. However, the median comparison enables some inference on the absolute scale. There are two interpretations of this test for absolute abundance associations:

In linear models, if two features’ associations with a particular metadatum on the log absolute scale differ by some value \(d\), the features’ associations with that metadatum on the log relative scale (total-sum scaling) will also differ by \(d\). Therefore, the test against the median can always be interpreted as a test of whether a particular association is significantly different from the typical association on the absolute scale. (Or, equivalently because of the 1-1 relation, this tests whether a particular association is significantly different from the typical association on the relative scale).
Under the assumption that at least half the features are not changing on the absolute scale, the median true absolute coefficient is 0, so this can be interpreted as a test of whether the feature has a non-zero association on the absolute scale

By contrast, sparsity should be less affected by compositionality since a feature should still be present even if another increases or decreases in abundance. (However, because the read depth is finite, this might not perfectly hold.) Therefore, median_comparison_prevalence is off by default, but it can be turned on if the user is interested in testing whether a particular prevalence association is significantly different from the typical prevalence association.

In both cases, if the tested coefficient is within median_comparison_[abundance/prevalence]_threshold of the median, it will automatically receive a p-value of 1. This is based on the idea that the association might be statistically significantly different but not substantially different from the median and therefore is likely still a compositional effect.

To conclude:

median_comparison_abundance is TRUE by default and should be used to make inference on the absolute scale when using relative abundance data.
median_comparison_abundance should be FALSE when (1) testing for significant relative associations, (2) testing for absolute abundance associations under the assumption that the total absolute abundance is not changing, or (3) testing for significant absolute associations when supplying spike-in or total abundances with unscaled_abundance.
median_comparison_prevalence is FALSE by default since most analysis focuses on whether a prevalence association is non-zero, not whether it is significantly different from the typical prevalence association.

3.3 MaAsLin 3 Output

Significant associations

The main output from MaAsLin 3 is the list of significant associations in significant_results.tsv. This lists all associations that pass MaAsLin 3’s significance threshold, ordered by increasing joint q-value. The format is:

Columns 1 and 2 are the feature and metadata names.
Columns 3 and 4 are the value of the metadata and variable name from the model.
Columns 5 and 6 are the fit coefficient and standard error from the model.
Columns 7 and 8 are the p-value and FDR corrected q-value of the individual association.
Column 9 species whether the association is abundance or prevalence.
Column 10 is the total number of data points.
Column 11 is the total number of non-zero data points.
Columns 12 and 13 are the p-value and q-value of the joint prevalence and abundance association.

feature	metadata	value	name	coef	stderr	pval_individual	qval_individual	model	N	N.not.zero	pval_joint	qval_joint
Escherichia_coli	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	3.53	0.387	0	0	abundance	1530	707	0	0
Veillonella_parvula	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	4.05	0.488	0	0	abundance	1530	547	0	0
Escherichia_coli	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.58	0.237	2.57e-11	2.92e-10	prevalence	1530	707	0	0
Veillonella_parvula	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.852	0.215	7.22e-05	0.000245	prevalence	1530	547	0	0
Phocaeicola_sartorii	reads	reads	reads	-0.24	0.148	1	1	abundance	1530	424	1.08e-43	3.82e-41
Phocaeicola_sartorii	reads	reads	reads	1.1	0.0787	5.42e-44	5.73e-41	prevalence	1530	424	1.08e-43	3.82e-41
Faecalibacterium_prausnitzii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.18	0.309	2.91e-10	1.64e-08	abundance	1530	1370	7.09e-35	1.87e-32
Faecalibacterium_prausnitzii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.49	0.282	3.54e-35	1.87e-32	prevalence	1530	1370	7.09e-35	1.87e-32
Bacteroides_uniformis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.12	0.396	3.99e-13	3.99e-11	abundance	1530	1240	3.15e-31	6.66e-29
Bacteroides_uniformis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.91	0.249	1.58e-31	5.55e-29	prevalence	1530	1240	3.15e-31	6.66e-29
Bifidobacterium_longum	age	age	age	-0.129	0.106	1	1	abundance	1530	843	2.02e-29	3.56e-27
Bifidobacterium_longum	age	age	age	-0.672	0.0594	1.01e-29	2.67e-27	prevalence	1530	843	2.02e-29	3.56e-27
Clostridium_sp_AM49_4BH	diagnosis	CD	diagnosisCD	-0.68	0.344	0.0769	0.188	abundance	1530	344	2.22e-28	3.36e-26
Clostridium_sp_AM49_4BH	diagnosis	CD	diagnosisCD	-1.81	0.163	1.11e-28	2.35e-26	prevalence	1530	344	2.22e-28	3.36e-26
Phocaeicola_dorei	reads	reads	reads	-0.519	0.197	1	1	abundance	1530	769	5.13e-25	6.77e-23
Phocaeicola_dorei	reads	reads	reads	0.66	0.0634	2.56e-25	4.51e-23	prevalence	1530	769	5.13e-25	6.77e-23
GGB16040_SGB9347	age	age	age	-0.378	0.297	0.219	0.421	abundance	1530	114	5.29e-24	6.21e-22
GGB16040_SGB9347	age	age	age	0.96	0.0944	2.65e-24	4e-22	prevalence	1530	114	5.29e-24	6.21e-22
Firmicutes_bacterium_AF16_15	diagnosis	UC	diagnosisUC	-0.47	0.246	0.0275	0.084	abundance	1530	827	1.35e-23	1.43e-21
Firmicutes_bacterium_AF16_15	diagnosis	UC	diagnosisUC	-1.67	0.166	6.77e-24	8.95e-22	prevalence	1530	827	1.35e-23	1.43e-21
Eubacterium_rectale	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.602	0.386	0.321	0.557	abundance	1530	1210	4.94e-23	4.74e-21
Eubacterium_rectale	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.36	0.237	2.47e-23	2.9e-21	prevalence	1530	1210	4.94e-23	4.74e-21
Phascolarctobacterium_faecium	age	age	age	0.186	0.104	1	1	abundance	1530	503	6.39e-23	5.63e-21
Phascolarctobacterium_faecium	age	age	age	0.574	0.0578	3.19e-23	3.38e-21	prevalence	1530	503	6.39e-23	5.63e-21
Dysosmobacter_welbionis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.7	0.342	0.00732	0.0295	abundance	1530	1190	7.38e-23	6e-21
Dysosmobacter_welbionis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.4	0.242	3.69e-23	3.55e-21	prevalence	1530	1190	7.38e-23	6e-21
Blautia_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.03	0.474	0.00846	0.0334	abundance	1530	1120	5.31e-22	4.01e-20
Blautia_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.42	0.249	2.66e-22	2.34e-20	prevalence	1530	1120	5.31e-22	4.01e-20
Fusicatenibacter_saccharivorans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.311	0.4	0.186	0.375	abundance	1530	1120	9.03e-22	6.37e-20
Fusicatenibacter_saccharivorans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.35	0.243	4.52e-22	3.67e-20	prevalence	1530	1120	9.03e-22	6.37e-20
Prevotella_sp_885	age	age	age	1.28	0.566	0.0261	0.0803	abundance	1530	69	2.48e-21	1.64e-19
Prevotella_sp_885	age	age	age	1.13	0.118	1.24e-21	9.37e-20	prevalence	1530	69	2.48e-21	1.64e-19
Lachnospira_sp_NSJ_43	diagnosis	CD	diagnosisCD	-0.403	0.401	0.406	0.662	abundance	1530	296	1.79e-20	1.11e-18
Lachnospira_sp_NSJ_43	diagnosis	CD	diagnosisCD	-1.65	0.177	8.94e-21	6.3e-19	prevalence	1530	296	1.79e-20	1.11e-18
Bacteroides_ovatus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.278	0.429	0.248	0.456	abundance	1530	1180	2.18e-20	1.28e-18
Bacteroides_ovatus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.13	0.228	1.09e-20	7.21e-19	prevalence	1530	1180	2.18e-20	1.28e-18
Clostridium_sp_AM49_4BH	diagnosis	UC	diagnosisUC	0.136	0.357	1	1	abundance	1530	344	5.02e-20	2.79e-18
Clostridium_sp_AM49_4BH	diagnosis	UC	diagnosisUC	-1.57	0.17	2.51e-20	1.56e-18	prevalence	1530	344	5.02e-20	2.79e-18
Bacteroides_faecis	reads	reads	reads	-0.841	0.177	0.00513	0.0221	abundance	1530	434	1.49e-19	7.88e-18
Bacteroides_faecis	reads	reads	reads	0.6	0.0657	7.46e-20	4.38e-18	prevalence	1530	434	1.49e-19	7.88e-18
Phocaeicola_vulgatus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.59	0.507	3.26e-06	5.35e-05	abundance	1530	1290	1.74e-19	8.74e-18
Phocaeicola_vulgatus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.07	0.228	8.68e-20	4.83e-18	prevalence	1530	1290	1.74e-19	8.74e-18
Dysosmobacter_welbionis	reads	reads	reads	-0.207	0.0627	1	1	abundance	1530	1190	4.2e-19	2.02e-17
Dysosmobacter_welbionis	reads	reads	reads	0.719	0.0798	2.1e-19	1.11e-17	prevalence	1530	1190	4.2e-19	2.02e-17
Roseburia_sp_AF02_12	diagnosis	CD	diagnosisCD	0.519	0.382	0.125	0.277	abundance	1530	363	4.87e-19	2.24e-17
Roseburia_sp_AF02_12	diagnosis	CD	diagnosisCD	-1.38	0.154	2.44e-19	1.23e-17	prevalence	1530	363	4.87e-19	2.24e-17
Clostridiales_bacterium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.03	0.557	0.0252	0.0796	abundance	1530	985	7.12e-19	3.14e-17
Clostridiales_bacterium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.46	0.275	3.56e-19	1.71e-17	prevalence	1530	985	7.12e-19	3.14e-17
Alistipes_putredinis	diagnosis	UC	diagnosisUC	-1.4	0.225	8.37e-11	5.79e-09	abundance	1530	873	1.01e-18	4.28e-17
Alistipes_putredinis	diagnosis	UC	diagnosisUC	-1.42	0.159	5.06e-19	2.33e-17	prevalence	1530	873	1.01e-18	4.28e-17
Bacteroides_xylanisolvens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.81	0.691	0.000185	0.00145	abundance	1530	959	1.06e-18	4.3e-17
Bacteroides_xylanisolvens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.12	0.238	5.29e-19	2.33e-17	prevalence	1530	959	1.06e-18	4.3e-17
Parabacteroides_distasonis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.119	0.334	1	1	abundance	1530	1140	1.62e-18	6.33e-17
Parabacteroides_distasonis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.99	0.225	8.09e-19	3.42e-17	prevalence	1530	1140	1.62e-18	6.33e-17
Clostridium_sp_AT4	diagnosis	UC	diagnosisUC	0.939	0.31	0.00541	0.0231	abundance	1530	528	2.99e-18	1.13e-16
Clostridium_sp_AT4	diagnosis	UC	diagnosisUC	1.41	0.161	1.5e-18	6.08e-17	prevalence	1530	528	2.99e-18	1.13e-16
Gemmiger_formicilis	diagnosis	UC	diagnosisUC	1.41	0.36	0.000217	0.00164	abundance	1530	472	3.29e-18	1.2e-16
Gemmiger_formicilis	diagnosis	UC	diagnosisUC	-1.45	0.165	1.65e-18	6.44e-17	prevalence	1530	472	3.29e-18	1.2e-16
Coprococcus_eutactus	age	age	age	-0.172	0.204	1	1	abundance	1530	177	3.81e-18	1.34e-16
Coprococcus_eutactus	age	age	age	0.649	0.0741	1.91e-18	7.2e-17	prevalence	1530	177	3.81e-18	1.34e-16
Alistipes_SGB2313	age	age	age	1.01	0.302	0.00116	0.0067	abundance	1530	73	4.82e-18	1.64e-16
Alistipes_SGB2313	age	age	age	0.949	0.109	2.41e-18	8.78e-17	prevalence	1530	73	4.82e-18	1.64e-16
GGB1549_SGB2133	age	age	age	2.2	0.5	7.68e-05	0.000692	abundance	1530	46	9.43e-18	3.12e-16
Vescimonas_coprocola	diagnosis	CD	diagnosisCD	0.426	0.23	0.0318	0.0929	abundance	1530	599	1.21e-17	3.86e-16
Vescimonas_coprocola	diagnosis	CD	diagnosisCD	-1.2	0.139	6.03e-18	2.06e-16	prevalence	1530	599	1.21e-17	3.86e-16
Clostridium_fessum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.66	0.603	0.0172	0.0575	abundance	1530	926	1.34e-17	4.17e-16
Clostridium_fessum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.66	0.309	6.71e-18	2.22e-16	prevalence	1530	926	1.34e-17	4.17e-16
Bacteroides_thetaiotaomicron	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.592	0.549	0.14	0.299	abundance	1530	1060	1.66e-17	5.02e-16
Bacteroides_thetaiotaomicron	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.06	0.239	8.31e-18	2.66e-16	prevalence	1530	1060	1.66e-17	5.02e-16
Lacrimispora_amygdalina	age	age	age	-0.331	0.0802	7.15e-05	0.000657	abundance	1530	865	3.54e-17	1.04e-15
Lacrimispora_amygdalina	age	age	age	-0.491	0.0577	1.77e-17	5.5e-16	prevalence	1530	865	3.54e-17	1.04e-15
GGB9342_SGB14306	age	age	age	0.804	0.0958	4.87e-17	1.35e-15	prevalence	1530	92	4.87e-17	1.39e-15
Alistipes_putredinis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.33	0.577	9.33e-08	2.71e-06	abundance	1530	873	5.18e-17	1.44e-15
Alistipes_putredinis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.34	0.276	2.59e-17	7.82e-16	prevalence	1530	873	5.18e-17	1.44e-15
Anaerostipes_hadrus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.026	0.41	1	1	abundance	1530	1130	5.89e-17	1.56e-15
Bacteroides_intestinalis	age	age	age	0.592	0.221	0.00727	0.0295	abundance	1530	158	5.78e-17	1.56e-15
Anaerostipes_hadrus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2	0.237	2.94e-17	8.41e-16	prevalence	1530	1130	5.89e-17	1.56e-15
Bacteroides_intestinalis	age	age	age	0.667	0.079	2.89e-17	8.41e-16	prevalence	1530	158	5.78e-17	1.56e-15
Bacteroides_cellulosilyticus	age	age	age	0.675	0.158	1.72e-05	0.000204	abundance	1530	433	1.21e-16	3.12e-15
Bacteroides_cellulosilyticus	age	age	age	0.483	0.0578	6.04e-17	1.64e-15	prevalence	1530	433	1.21e-16	3.12e-15
Candidatus_Cibionibacter_quicibialis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.551	0.54	0.155	0.324	abundance	1530	933	1.43e-16	3.59e-15
Candidatus_Cibionibacter_quicibialis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.09	0.25	7.14e-17	1.89e-15	prevalence	1530	933	1.43e-16	3.59e-15
Bacteroides_eggerthii	reads	reads	reads	-1.02	0.225	0.00288	0.0139	abundance	1530	409	2.79e-16	6.85e-15
Bacteroides_eggerthii	reads	reads	reads	0.552	0.0668	1.39e-16	3.59e-15	prevalence	1530	409	2.79e-16	6.85e-15
Veillonella_dispar	age	age	age	-0.203	0.163	1	1	abundance	1530	526	4.49e-16	1.08e-14
Veillonella_dispar	age	age	age	-0.527	0.0642	2.25e-16	5.65e-15	prevalence	1530	526	4.49e-16	1.08e-14
Haemophilus_parainfluenzae	age	age	age	-0.22	0.117	1	1	abundance	1530	674	6.58e-16	1.55e-14
Haemophilus_parainfluenzae	age	age	age	-0.473	0.058	3.29e-16	8.09e-15	prevalence	1530	674	6.58e-16	1.55e-14
Faecalibacterium_prausnitzii	age	age	age	-0.442	0.0524	4.44e-16	1.33e-13	abundance	1530	1370	8.88e-16	2.04e-14
Faecalibacterium_prausnitzii	age	age	age	-0.56	0.103	5.4e-08	3.3e-07	prevalence	1530	1370	8.88e-16	2.04e-14
Bacteroides_caccae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.25	0.424	0.0157	0.0543	abundance	1530	958	1.46e-15	3.28e-14
Bacteroides_caccae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.92	0.238	7.28e-16	1.75e-14	prevalence	1530	958	1.46e-15	3.28e-14
Clostridium_sp_AF34_10BH	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.586	0.68	0.237	0.442	abundance	1530	960	1.64e-15	3.61e-14
Clostridium_sp_AF34_10BH	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.33	0.289	8.19e-16	1.92e-14	prevalence	1530	960	1.64e-15	3.61e-14
Flavonifractor_plautii	reads	reads	reads	-0.287	0.0722	1	1	abundance	1530	1220	3.2e-15	6.91e-14
Flavonifractor_plautii	reads	reads	reads	0.611	0.0766	1.6e-15	3.68e-14	prevalence	1530	1220	3.2e-15	6.91e-14
Enterocloster_bolteae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.75	0.366	1.67e-15	3.75e-13	abundance	1530	866	3.33e-15	7.04e-14
Enterocloster_bolteae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.133	0.209	0.525	0.62	prevalence	1530	866	3.33e-15	7.04e-14
Bacteroides_ovatus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.58	0.745	0.114	0.256	abundance	1530	1180	9e-15	1.83e-13
Ruminococcus_gnavus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.52	0.341	4.44e-15	7.99e-13	abundance	1530	767	8.88e-15	1.83e-13
Bacteroides_ovatus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.97	0.379	4.5e-15	1.01e-13	prevalence	1530	1180	9e-15	1.83e-13
Ruminococcus_gnavus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.01	0.225	8.05e-06	3.44e-05	prevalence	1530	767	8.88e-15	1.83e-13
Bacteroides_xylanisolvens	diagnosis	UC	diagnosisUC	-2.51	0.326	7.22e-15	1.08e-12	abundance	1530	959	1.44e-14	2.88e-13
Bacteroides_xylanisolvens	diagnosis	UC	diagnosisUC	-0.164	0.149	0.271	0.363	prevalence	1530	959	1.44e-14	2.88e-13
Clostridium_sp_AF20_17LB	diagnosis	UC	diagnosisUC	2.15	0.262	9.44e-15	1.14e-12	abundance	1530	654	1.89e-14	3.69e-13
Clostridium_sp_AF20_17LB	diagnosis	UC	diagnosisUC	0.71	0.147	1.33e-06	6.63e-06	prevalence	1530	654	1.89e-14	3.69e-13
Dysosmobacter_welbionis	diagnosis	UC	diagnosisUC	1.33	0.161	1.01e-14	1.14e-12	abundance	1530	1190	2.02e-14	3.88e-13
Dysosmobacter_welbionis	diagnosis	UC	diagnosisUC	0.478	0.192	0.0128	0.0266	prevalence	1530	1190	2.02e-14	3.88e-13
Bifidobacterium_adolescentis	diagnosis	CD	diagnosisCD	-0.685	0.346	0.0761	0.188	abundance	1530	427	2.25e-14	4.24e-13
Bifidobacterium_adolescentis	diagnosis	CD	diagnosisCD	-1.17	0.151	1.12e-14	2.48e-13	prevalence	1530	427	2.25e-14	4.24e-13
Clostridiales_bacterium	reads	reads	reads	-0.247	0.0796	1	1	abundance	1530	985	2.7e-14	5.01e-13
Clostridiales_bacterium	reads	reads	reads	0.508	0.066	1.35e-14	2.91e-13	prevalence	1530	985	2.7e-14	5.01e-13
GGB1543_SGB2126	age	age	age	-0.554	0.693	0.438	0.702	abundance	1530	42	2.81e-14	5.12e-13
GGB9713_SGB15249	diagnosis	UC	diagnosisUC	-0.385	0.436	0.294	0.519	abundance	1530	329	3.15e-14	5.65e-13
GGB9713_SGB15249	diagnosis	UC	diagnosisUC	-1.44	0.187	1.58e-14	3.27e-13	prevalence	1530	329	3.15e-14	5.65e-13
Clostridium_symbiosum	diagnosis	UC	diagnosisUC	-0.719	0.346	0.0227	0.0723	abundance	1530	539	4.2e-14	7.28e-13
Clostridium_symbiosum	diagnosis	UC	diagnosisUC	1.25	0.163	2.1e-14	4.27e-13	prevalence	1530	539	4.2e-14	7.28e-13
Alistipes_onderdonkii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.01	0.675	3.95e-05	0.000404	abundance	1530	831	4.73e-14	8.06e-13
Alistipes_onderdonkii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.08	0.272	2.36e-14	4.71e-13	prevalence	1530	831	4.73e-14	8.06e-13
Odoribacter_splanchnicus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.07	0.395	0.0304	0.0902	abundance	1530	757	5.69e-14	9.55e-13
Odoribacter_splanchnicus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.96	0.257	2.85e-14	5.57e-13	prevalence	1530	757	5.69e-14	9.55e-13
Veillonella_parvula	age	age	age	0.17	0.159	1	1	abundance	1530	547	1.04e-13	1.72e-12
Veillonella_parvula	age	age	age	-0.463	0.0615	5.2e-14	9.82e-13	prevalence	1530	547	1.04e-13	1.72e-12
Vescimonas_coprocola	diagnosis	UC	diagnosisUC	-0.0765	0.256	1	1	abundance	1530	599	1.11e-13	1.81e-12
Vescimonas_coprocola	diagnosis	UC	diagnosisUC	-1.12	0.149	5.55e-14	1.03e-12	prevalence	1530	599	1.11e-13	1.81e-12
Lachnospira_sp_NSJ_43	age	age	age	0.837	0.139	3.57e-09	1.46e-07	abundance	1530	296	1.17e-13	1.87e-12
Lachnospira_sp_NSJ_43	age	age	age	0.486	0.0646	5.83e-14	1.06e-12	prevalence	1530	296	1.17e-13	1.87e-12
Odoribacter_splanchnicus	diagnosis	UC	diagnosisUC	-0.72	0.187	2.58e-05	0.000283	abundance	1530	757	1.61e-13	2.55e-12
Odoribacter_splanchnicus	diagnosis	UC	diagnosisUC	-1.11	0.149	8.07e-14	1.45e-12	prevalence	1530	757	1.61e-13	2.55e-12
Blautia_wexlerae	reads	reads	reads	-0.497	0.0687	1	1	abundance	1530	1300	1.68e-13	2.62e-12
Blautia_wexlerae	reads	reads	reads	0.657	0.0881	8.42e-14	1.48e-12	prevalence	1530	1300	1.68e-13	2.62e-12
Blautia_faecis	reads	reads	reads	-0.558	0.0751	1	1	abundance	1530	1120	1.73e-13	2.65e-12
Blautia_faecis	reads	reads	reads	0.528	0.0708	8.64e-14	1.5e-12	prevalence	1530	1120	1.73e-13	2.65e-12
Roseburia_sp_AF02_12	diagnosis	UC	diagnosisUC	0.598	0.412	0.203	0.397	abundance	1530	363	2.39e-13	3.61e-12
Roseburia_sp_AF02_12	diagnosis	UC	diagnosisUC	-1.22	0.165	1.2e-13	2.04e-12	prevalence	1530	363	2.39e-13	3.61e-12
Coprococcus_comes	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.42	0.684	0.00133	0.0076	abundance	1530	759	3.01e-13	4.49e-12
Coprococcus_comes	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.52	0.341	1.51e-13	2.53e-12	prevalence	1530	759	3.01e-13	4.49e-12
Firmicutes_bacterium_AF16_15	diagnosis	CD	diagnosisCD	0.0485	0.207	1	1	abundance	1530	827	3.38e-13	4.96e-12
Firmicutes_bacterium_AF16_15	diagnosis	CD	diagnosisCD	-1.16	0.158	1.69e-13	2.79e-12	prevalence	1530	827	3.38e-13	4.96e-12
Dialister_invisus	age	age	age	0.192	0.0944	1	1	abundance	1530	726	4.47e-13	6.48e-12
Dialister_invisus	age	age	age	-0.416	0.0567	2.24e-13	3.64e-12	prevalence	1530	726	4.47e-13	6.48e-12
Bilophila_wadsworthia	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.19	0.596	0.105	0.242	abundance	1530	764	4.72e-13	6.75e-12
Bilophila_wadsworthia	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.15	0.293	2.36e-13	3.78e-12	prevalence	1530	764	4.72e-13	6.75e-12
Faecalibacterium_SGB15346	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.39	0.848	0.000198	0.00151	abundance	1530	743	7.55e-13	1.06e-11
Faecalibacterium_SGB15346	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.47	0.341	3.78e-13	5.96e-12	prevalence	1530	743	7.55e-13	1.06e-11
Alistipes_shahii	diagnosis	UC	diagnosisUC	-0.547	0.21	0.00329	0.0154	abundance	1530	673	8.2e-13	1.14e-11
Alistipes_shahii	diagnosis	UC	diagnosisUC	-1.08	0.149	4.1e-13	6.38e-12	prevalence	1530	673	8.2e-13	1.14e-11
Bacteroides_eggerthii	diagnosis	CD	diagnosisCD	-1.86	0.573	0.00188	0.00989	abundance	1530	409	1.06e-12	1.45e-11
Bacteroides_eggerthii	diagnosis	CD	diagnosisCD	-1.09	0.152	5.28e-13	8.08e-12	prevalence	1530	409	1.06e-12	1.45e-11
Parabacteroides_distasonis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.576	0.667	0.142	0.302	abundance	1530	1140	1.09e-12	1.47e-11
Parabacteroides_distasonis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.88	0.4	5.43e-13	8.19e-12	prevalence	1530	1140	1.09e-12	1.47e-11
Clostridium_symbiosum	age	age	age	-0.478	0.146	0.00144	0.00812	abundance	1530	539	1.18e-12	1.58e-11
Clostridium_symbiosum	age	age	age	-0.459	0.0637	5.89e-13	8.78e-12	prevalence	1530	539	1.18e-12	1.58e-11
Alistipes_onderdonkii	diagnosis	UC	diagnosisUC	-1.05	0.265	2.27e-05	0.000255	abundance	1530	831	1.3e-12	1.71e-11
Alistipes_onderdonkii	diagnosis	UC	diagnosisUC	-1.09	0.152	6.49e-13	9.52e-12	prevalence	1530	831	1.3e-12	1.71e-11
Sutterella_wadsworthensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.64	0.391	9.57e-13	8.61e-11	abundance	1530	536	1.91e-12	2.5e-11
Sutterella_wadsworthensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.687	0.241	0.00433	0.00995	prevalence	1530	536	1.91e-12	2.5e-11
Blautia_wexlerae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.956	0.324	0.000296	0.00207	abundance	1530	1300	2.21e-12	2.85e-11
Blautia_wexlerae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.66	0.234	1.11e-12	1.6e-11	prevalence	1530	1300	2.21e-12	2.85e-11
Alistipes_communis	age	age	age	0.321	0.105	0.00178	0.00942	abundance	1530	407	2.56e-12	3.26e-11
Alistipes_communis	age	age	age	0.423	0.0596	1.28e-12	1.83e-11	prevalence	1530	407	2.56e-12	3.26e-11
Ruminococcus_lactaris	diagnosis	CD	diagnosisCD	-0.82	0.325	0.0214	0.0688	abundance	1530	379	3.48e-12	4.38e-11
Ruminococcus_lactaris	diagnosis	CD	diagnosisCD	-1.1	0.156	1.74e-12	2.46e-11	prevalence	1530	379	3.48e-12	4.38e-11
Parabacteroides_merdae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.56	0.51	5.11e-06	7.92e-05	abundance	1530	826	3.66e-12	4.55e-11
Parabacteroides_merdae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.87	0.266	1.83e-12	2.54e-11	prevalence	1530	826	3.66e-12	4.55e-11
GGB9713_SGB15249	age	age	age	-0.15	0.138	1	1	abundance	1530	329	3.71e-12	4.57e-11
GGB9713_SGB15249	age	age	age	0.438	0.0622	1.86e-12	2.55e-11	prevalence	1530	329	3.71e-12	4.57e-11
Eubacterium_rectale	antibiotics	Yes	antibioticsYes	-0.368	0.273	0.28	0.501	abundance	1530	1210	5.32e-12	6.46e-11
Eubacterium_rectale	antibiotics	Yes	antibioticsYes	-1.41	0.201	2.66e-12	3.6e-11	prevalence	1530	1210	5.32e-12	6.46e-11
Blautia_obeum	reads	reads	reads	-0.342	0.089	1	1	abundance	1530	899	5.65e-12	6.79e-11
Blautia_obeum	reads	reads	reads	0.417	0.0597	2.83e-12	3.78e-11	prevalence	1530	899	5.65e-12	6.79e-11
Clostridiaceae_bacterium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.106	0.357	1	1	abundance	1530	1110	6.6e-12	7.84e-11
Clostridiaceae_bacterium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.55	0.223	3.3e-12	4.36e-11	prevalence	1530	1110	6.6e-12	7.84e-11
Akkermansia_muciniphila	age	age	age	0.292	0.141	0.0323	0.094	abundance	1530	407	7.32e-12	8.6e-11
Akkermansia_muciniphila	age	age	age	0.403	0.058	3.66e-12	4.78e-11	prevalence	1530	407	7.32e-12	8.6e-11
Ruthenibacterium_lactatiformans	reads	reads	reads	-0.767	0.101	2.93e-05	0.000318	abundance	1530	797	7.86e-12	9.13e-11
Ruthenibacterium_lactatiformans	reads	reads	reads	0.404	0.0582	3.93e-12	5.07e-11	prevalence	1530	797	7.86e-12	9.13e-11
Clostridium_sp_1001270H_150608_G6	diagnosis	UC	diagnosisUC	-3.08	0.754	5.22e-05	0.000516	abundance	1530	141	9.16e-12	1.05e-10
Clostridium_sp_1001270H_150608_G6	diagnosis	UC	diagnosisUC	-2.02	0.292	4.58e-12	5.83e-11	prevalence	1530	141	9.16e-12	1.05e-10
Firmicutes_bacterium_AF16_15	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.63	0.725	0.000922	0.00549	abundance	1530	827	1.4e-11	1.59e-10
Firmicutes_bacterium_AF16_15	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.12	0.309	6.99e-12	8.8e-11	prevalence	1530	827	1.4e-11	1.59e-10
Klebsiella_pneumoniae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	3.69	0.654	2.8e-08	8.99e-07	abundance	1530	119	1.43e-11	1.6e-10
Klebsiella_pneumoniae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.81	0.264	7.13e-12	8.87e-11	prevalence	1530	119	1.43e-11	1.6e-10
Bacteroides_stercoris	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.45	0.744	1.54e-05	0.000192	abundance	1530	826	1.66e-11	1.84e-10
Bacteroides_stercoris	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.82	0.266	8.28e-12	1.02e-10	prevalence	1530	826	1.66e-11	1.84e-10
Gemmiger_formicilis	diagnosis	CD	diagnosisCD	-0.469	0.252	0.113	0.256	abundance	1530	472	2.33e-11	2.57e-10
Gemmiger_formicilis	diagnosis	CD	diagnosisCD	-0.948	0.14	1.17e-11	1.42e-10	prevalence	1530	472	2.33e-11	2.57e-10
Eubacterium_rectale	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.23	0.708	0.243	0.451	abundance	1530	1210	2.53e-11	2.75e-10
Eubacterium_rectale	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.59	0.383	1.26e-11	1.52e-10	prevalence	1530	1210	2.53e-11	2.75e-10
Lacrimispora_celerecrescens	diagnosis	UC	diagnosisUC	1.47	0.203	1.31e-11	9.92e-10	abundance	1530	756	2.61e-11	2.82e-10
Lacrimispora_celerecrescens	diagnosis	UC	diagnosisUC	0.0908	0.146	0.535	0.629	prevalence	1530	756	2.61e-11	2.82e-10
Blautia_obeum	diagnosis	UC	diagnosisUC	1.62	0.225	1.32e-11	9.92e-10	abundance	1530	899	2.64e-11	2.82e-10
Blautia_obeum	diagnosis	UC	diagnosisUC	0.387	0.151	0.0106	0.0224	prevalence	1530	899	2.64e-11	2.82e-10
Clostridiaceae_bacterium	reads	reads	reads	-0.304	0.071	1	1	abundance	1530	1110	2.73e-11	2.88e-10
Clostridiaceae_bacterium	reads	reads	reads	0.46	0.068	1.36e-11	1.62e-10	prevalence	1530	1110	2.73e-11	2.88e-10
Clostridium_sp_AF34_10BH	reads	reads	reads	-0.253	0.0925	1	1	abundance	1530	960	2.91e-11	3.05e-10
Clostridium_sp_AF34_10BH	reads	reads	reads	0.433	0.0641	1.46e-11	1.71e-10	prevalence	1530	960	2.91e-11	3.05e-10
Oscillibacter_sp_ER4	age	age	age	-0.0811	0.0963	1	1	abundance	1530	458	3.51e-11	3.64e-10
Oscillibacter_sp_ER4	age	age	age	0.385	0.0572	1.76e-11	2.04e-10	prevalence	1530	458	3.51e-11	3.64e-10
Dorea_longicatena	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.464	0.375	0.0695	0.176	abundance	1530	1020	3.6e-11	3.7e-10
Dorea_longicatena	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.51	0.224	1.8e-11	2.07e-10	prevalence	1530	1020	3.6e-11	3.7e-10
Ruminococcus_bicirculans	diagnosis	CD	diagnosisCD	0.127	0.24	1	1	abundance	1530	678	8.04e-11	8.17e-10
Ruminococcus_bicirculans	diagnosis	CD	diagnosisCD	-0.903	0.137	4.02e-11	4.52e-10	prevalence	1530	678	8.04e-11	8.17e-10
Lachnospira_sp_NSJ_43	diagnosis	UC	diagnosisUC	-0.786	0.383	0.0256	0.0798	abundance	1530	296	8.59e-11	8.65e-10
Lachnospira_sp_NSJ_43	diagnosis	UC	diagnosisUC	-1.13	0.171	4.3e-11	4.78e-10	prevalence	1530	296	8.59e-11	8.65e-10
Enterocloster_bolteae	diagnosis	UC	diagnosisUC	-0.136	0.271	1	1	abundance	1530	866	1.03e-10	1.02e-09
Enterocloster_bolteae	diagnosis	UC	diagnosisUC	0.975	0.149	5.13e-11	5.65e-10	prevalence	1530	866	1.03e-10	1.02e-09
Anaerostipes_hadrus	antibiotics	Yes	antibioticsYes	-0.209	0.29	1	1	abundance	1530	1130	1.04e-10	1.03e-09
Anaerostipes_hadrus	antibiotics	Yes	antibioticsYes	-1.28	0.194	5.2e-11	5.67e-10	prevalence	1530	1130	1.04e-10	1.03e-09
Alistipes_shahii	diagnosis	CD	diagnosisCD	-0.171	0.186	1	1	abundance	1530	673	1.1e-10	1.08e-09
Alistipes_shahii	diagnosis	CD	diagnosisCD	-0.898	0.137	5.52e-11	5.95e-10	prevalence	1530	673	1.1e-10	1.08e-09
Clostridium_sp_1001270H_150608_G6	diagnosis	CD	diagnosisCD	0.873	0.531	0.0784	0.191	abundance	1530	141	1.12e-10	1.09e-09
Clostridium_sp_1001270H_150608_G6	diagnosis	CD	diagnosisCD	-1.42	0.216	5.6e-11	5.98e-10	prevalence	1530	141	1.12e-10	1.09e-09
Firmicutes_bacterium_AF16_15	age	age	age	-0.435	0.0948	8.79e-06	0.000122	abundance	1530	827	1.2e-10	1.15e-09
Firmicutes_bacterium_AF16_15	age	age	age	-0.395	0.0604	6e-11	6.34e-10	prevalence	1530	827	1.2e-10	1.15e-09
Roseburia_hominis	diagnosis	UC	diagnosisUC	0.0713	0.231	1	1	abundance	1530	876	1.39e-10	1.33e-09
Roseburia_hominis	diagnosis	UC	diagnosisUC	-1.03	0.158	6.97e-11	7.29e-10	prevalence	1530	876	1.39e-10	1.33e-09
Flavonifractor_plautii	age	age	age	0.0302	0.0736	1	1	abundance	1530	1220	1.42e-10	1.34e-09
Flavonifractor_plautii	age	age	age	-0.419	0.0642	7.08e-11	7.33e-10	prevalence	1530	1220	1.42e-10	1.34e-09
Alistipes_finegoldii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.73	0.85	0.00318	0.0152	abundance	1530	639	1.77e-10	1.66e-09
Alistipes_finegoldii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.29	0.354	8.87e-11	9.1e-10	prevalence	1530	639	1.77e-10	1.66e-09
Enterocloster_bolteae	diagnosis	CD	diagnosisCD	0.635	0.253	0.00556	0.0236	abundance	1530	866	1.95e-10	1.81e-09
Enterocloster_bolteae	diagnosis	CD	diagnosisCD	0.881	0.136	9.73e-11	9.89e-10	prevalence	1530	866	1.95e-10	1.81e-09
Collinsella_SGB14861	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.738	0.817	0.525	0.816	abundance	1530	593	2.07e-10	1.91e-09
Collinsella_SGB14861	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.29	0.354	1.04e-10	1.04e-09	prevalence	1530	593	2.07e-10	1.91e-09
Blautia_obeum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.573	0.5	0.114	0.256	abundance	1530	899	2.33e-10	2.13e-09
Blautia_obeum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.53	0.237	1.17e-10	1.16e-09	prevalence	1530	899	2.33e-10	2.13e-09
Alistipes_dispar	age	age	age	0.834	0.269	0.00239	0.0121	abundance	1530	83	2.46e-10	2.21e-09
Alistipes_finegoldii	diagnosis	UC	diagnosisUC	-0.821	0.282	0.0016	0.00875	abundance	1530	639	2.48e-10	2.21e-09
Clostridium_fessum	reads	reads	reads	-0.381	0.0782	1	1	abundance	1530	926	2.48e-10	2.21e-09
Alistipes_dispar	age	age	age	0.647	0.101	1.23e-10	1.2e-09	prevalence	1530	83	2.46e-10	2.21e-09
Alistipes_finegoldii	diagnosis	UC	diagnosisUC	-0.952	0.148	1.24e-10	1.2e-09	prevalence	1530	639	2.48e-10	2.21e-09
Clostridium_fessum	reads	reads	reads	0.405	0.0629	1.24e-10	1.2e-09	prevalence	1530	926	2.48e-10	2.21e-09
Bacteroides_fragilis	diagnosis	CD	diagnosisCD	1.75	0.28	1.52e-10	9.75e-09	abundance	1530	787	3.03e-10	2.67e-09
Bacteroides_fragilis	diagnosis	CD	diagnosisCD	0.818	0.136	1.6e-09	1.24e-08	prevalence	1530	787	3.03e-10	2.67e-09
Ruminococcus_gnavus	age	age	age	-0.456	0.117	0.000161	0.0013	abundance	1530	767	3.17e-10	2.77e-09
Ruminococcus_gnavus	age	age	age	-0.356	0.0557	1.59e-10	1.52e-09	prevalence	1530	767	3.17e-10	2.77e-09
GGB33469_SGB15236	diagnosis	UC	diagnosisUC	0.603	0.417	0.204	0.398	abundance	1530	293	3.57e-10	3.09e-09
GGB33469_SGB15236	diagnosis	UC	diagnosisUC	-1.18	0.186	1.78e-10	1.7e-09	prevalence	1530	293	3.57e-10	3.09e-09
GGB3175_SGB4191	diagnosis	UC	diagnosisUC	0.35	0.846	0.743	1	abundance	1530	154	4.27e-10	3.67e-09
GGB3175_SGB4191	diagnosis	UC	diagnosisUC	-1.86	0.293	2.14e-10	2.02e-09	prevalence	1530	154	4.27e-10	3.67e-09
Roseburia_inulinivorans	antibiotics	Yes	antibioticsYes	-0.661	0.398	0.139	0.298	abundance	1530	951	4.41e-10	3.76e-09
Roseburia_inulinivorans	antibiotics	Yes	antibioticsYes	-1.26	0.199	2.2e-10	2.06e-09	prevalence	1530	951	4.41e-10	3.76e-09
Clostridium_symbiosum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.67	0.447	2.46e-10	1.48e-08	abundance	1530	539	4.92e-10	4.11e-09
GGB9453_SGB14844	age	age	age	0.132	0.175	1	1	abundance	1530	222	4.88e-10	4.11e-09
Lacrimispora_celerecrescens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.707	0.655	0.158	0.33	abundance	1530	756	4.94e-10	4.11e-09
Clostridium_symbiosum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.185	0.216	0.393	0.491	prevalence	1530	539	4.92e-10	4.11e-09
GGB9453_SGB14844	age	age	age	0.431	0.0681	2.44e-10	2.26e-09	prevalence	1530	222	4.88e-10	4.11e-09
Lacrimispora_celerecrescens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.07	0.327	2.47e-10	2.27e-09	prevalence	1530	756	4.94e-10	4.11e-09
Clostridium_sp_AM22_11AC	reads	reads	reads	-0.351	0.1	1	1	abundance	1530	730	7.24e-10	5.98e-09
Clostridium_sp_AM22_11AC	reads	reads	reads	0.362	0.0577	3.62e-10	3.3e-09	prevalence	1530	730	7.24e-10	5.98e-09
Bilophila_wadsworthia	reads	reads	reads	-0.285	0.0852	1	1	abundance	1530	764	8.37e-10	6.86e-09
Bilophila_wadsworthia	reads	reads	reads	0.374	0.0599	4.19e-10	3.78e-09	prevalence	1530	764	8.37e-10	6.86e-09
Dialister_invisus	antibiotics	Yes	antibioticsYes	-0.981	0.406	0.0255	0.0798	abundance	1530	726	8.73e-10	7.1e-09
Dialister_invisus	antibiotics	Yes	antibioticsYes	-1.3	0.208	4.37e-10	3.91e-09	prevalence	1530	726	8.73e-10	7.1e-09
Dysosmobacter_welbionis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.37	0.557	1	1	abundance	1530	1190	9e-10	7.27e-09
Dysosmobacter_welbionis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.35	0.378	4.5e-10	4e-09	prevalence	1530	1190	9e-10	7.27e-09
Ruminococcus_bromii	diagnosis	UC	diagnosisUC	-0.111	0.334	1	1	abundance	1530	429	9.24e-10	7.4e-09
Ruminococcus_bromii	diagnosis	UC	diagnosisUC	-1	0.161	4.62e-10	4.07e-09	prevalence	1530	429	9.24e-10	7.4e-09
Bacteroides_fragilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.79	0.478	4.87e-10	2.58e-08	abundance	1530	787	9.73e-10	7.74e-09
Bacteroides_fragilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.875	0.213	4.09e-05	0.000148	prevalence	1530	787	9.73e-10	7.74e-09
Clostridium_sp_AM22_11AC	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.3	0.698	0.123	0.272	abundance	1530	730	1.04e-09	8.24e-09
Clostridium_sp_AM22_11AC	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.91	0.307	5.22e-10	4.56e-09	prevalence	1530	730	1.04e-09	8.24e-09
Eubacterium_siraeum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.15	1.35	0.0309	0.0913	abundance	1530	565	1.19e-09	9.35e-09
Eubacterium_siraeum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.64	0.426	5.97e-10	5.17e-09	prevalence	1530	565	1.19e-09	9.35e-09
Bacteroides_thetaiotaomicron	age	age	age	0.529	0.0902	2.93e-09	1.3e-07	abundance	1530	1060	1.44e-09	1.11e-08
Faecalibacterium_prausnitzii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.0662	0.36	0.349	0.588	abundance	1530	1370	1.43e-09	1.11e-08
Bacteroides_thetaiotaomicron	age	age	age	0.423	0.0687	7.21e-10	6.15e-09	prevalence	1530	1060	1.44e-09	1.11e-08
Faecalibacterium_prausnitzii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.83	0.46	7.17e-10	6.15e-09	prevalence	1530	1370	1.43e-09	1.11e-08
Lacrimispora_amygdalina	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.86	0.491	2.49e-05	0.000277	abundance	1530	865	1.55e-09	1.19e-08
Lacrimispora_amygdalina	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.63	0.264	7.76e-10	6.56e-09	prevalence	1530	865	1.55e-09	1.19e-08
Phocaeicola_vulgatus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.22	0.746	0.000443	0.00293	abundance	1530	1290	1.6e-09	1.22e-08
Phocaeicola_vulgatus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.25	0.366	8.01e-10	6.72e-09	prevalence	1530	1290	1.6e-09	1.22e-08
Prevotella_copri_clade_A	reads	reads	reads	-0.427	0.254	1	1	abundance	1530	289	1.82e-09	1.38e-08
Prevotella_copri_clade_A	reads	reads	reads	0.421	0.0687	9.11e-10	7.58e-09	prevalence	1530	289	1.82e-09	1.38e-08
Oscillospiraceae_bacterium	age	age	age	0.227	0.264	0.37	0.617	abundance	1530	81	1.87e-09	1.4e-08
Oscillospiraceae_bacterium	age	age	age	0.615	0.1	9.33e-10	7.71e-09	prevalence	1530	81	1.87e-09	1.4e-08
Alistipes_shahii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.21	0.693	1.8e-05	0.000211	abundance	1530	673	2.12e-09	1.58e-08
Alistipes_shahii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.16	0.355	1.06e-09	8.68e-09	prevalence	1530	673	2.12e-09	1.58e-08
Roseburia_hominis	reads	reads	reads	-0.421	0.098	1	1	abundance	1530	876	2.21e-09	1.63e-08
Roseburia_hominis	reads	reads	reads	0.363	0.0595	1.11e-09	8.98e-09	prevalence	1530	876	2.21e-09	1.63e-08
Clostridium_fessum	diagnosis	UC	diagnosisUC	0.0143	0.189	1	1	abundance	1530	926	2.51e-09	1.84e-08
Clostridium_fessum	diagnosis	UC	diagnosisUC	-0.968	0.159	1.25e-09	1.01e-08	prevalence	1530	926	2.51e-09	1.84e-08
Ruminococcus_torques	reads	reads	reads	-0.544	0.0767	1	1	abundance	1530	1090	2.54e-09	1.85e-08
Ruminococcus_torques	reads	reads	reads	0.39	0.0643	1.27e-09	1.02e-08	prevalence	1530	1090	2.54e-09	1.85e-08
Clostridium_sp_AF20_17LB	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.727	1	0.347	0.587	abundance	1530	654	2.73e-09	1.98e-08
Clostridium_sp_AF20_17LB	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.55	0.421	1.37e-09	1.09e-08	prevalence	1530	654	2.73e-09	1.98e-08
GGB33469_SGB15236	age	age	age	0.366	0.152	0.0137	0.049	abundance	1530	293	2.92e-09	2.1e-08
GGB33469_SGB15236	age	age	age	0.382	0.0632	1.46e-09	1.15e-08	prevalence	1530	293	2.92e-09	2.1e-08
Coprococcus_eutactus	diagnosis	CD	diagnosisCD	-0.7	0.532	0.237	0.442	abundance	1530	177	3.01e-09	2.15e-08
Coprococcus_eutactus	diagnosis	CD	diagnosisCD	-1.35	0.224	1.5e-09	1.18e-08	prevalence	1530	177	3.01e-09	2.15e-08
Bacteroides_finegoldii	diagnosis	CD	diagnosisCD	-1.85	0.476	0.000218	0.00164	abundance	1530	333	3.29e-09	2.33e-08
Bacteroides_finegoldii	diagnosis	CD	diagnosisCD	-0.98	0.162	1.65e-09	1.27e-08	prevalence	1530	333	3.29e-09	2.33e-08
Faecalibacterium_SGB15315	reads	reads	reads	-0.231	0.138	1	1	abundance	1530	619	4.57e-09	3.22e-08
Faecalibacterium_SGB15315	reads	reads	reads	0.355	0.0594	2.29e-09	1.75e-08	prevalence	1530	619	4.57e-09	3.22e-08
Bacteroides_ovatus	age	age	age	-0.47	0.0764	2.43e-09	1.22e-07	abundance	1530	1180	4.87e-09	3.41e-08
Bacteroides_ovatus	age	age	age	-0.196	0.0647	0.00246	0.006	prevalence	1530	1180	4.87e-09	3.41e-08
Firmicutes_bacterium_AF16_15	reads	reads	reads	-0.251	0.0995	1	1	abundance	1530	827	4.99e-09	3.47e-08
Firmicutes_bacterium_AF16_15	reads	reads	reads	0.366	0.0614	2.49e-09	1.9e-08	prevalence	1530	827	4.99e-09	3.47e-08
Lachnospira_eligens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.491	0.515	0.168	0.346	abundance	1530	929	5.1e-09	3.52e-08
Lachnospira_eligens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.41	0.237	2.55e-09	1.92e-08	prevalence	1530	929	5.1e-09	3.52e-08
Sutterella_wadsworthensis	age	age	age	-0.621	0.101	2.85e-09	1.3e-07	abundance	1530	536	5.7e-09	3.92e-08
Sutterella_wadsworthensis	age	age	age	-0.271	0.0582	3.23e-06	1.5e-05	prevalence	1530	536	5.7e-09	3.92e-08
Clostridium_leptum	reads	reads	reads	-0.5	0.111	1	1	abundance	1530	652	5.78e-09	3.94e-08
Clostridium_leptum	reads	reads	reads	0.348	0.0586	2.89e-09	2.17e-08	prevalence	1530	652	5.78e-09	3.94e-08
Bacteroides_ovatus	diagnosis	UC	diagnosisUC	1.26	0.199	3.04e-09	1.3e-07	abundance	1530	1180	6.09e-09	4.12e-08
Bacteroides_ovatus	diagnosis	UC	diagnosisUC	0.872	0.2	1.27e-05	5.22e-05	prevalence	1530	1180	6.09e-09	4.12e-08
Clostridium_sp_AF20_17LB	reads	reads	reads	-0.177	0.103	1	1	abundance	1530	654	6.36e-09	4.28e-08
Clostridium_sp_AF20_17LB	reads	reads	reads	0.341	0.0575	3.18e-09	2.37e-08	prevalence	1530	654	6.36e-09	4.28e-08
Bacteroides_thetaiotaomicron	reads	reads	reads	-0.271	0.0982	1	1	abundance	1530	1060	6.77e-09	4.53e-08
Bacteroides_thetaiotaomicron	reads	reads	reads	0.387	0.0655	3.38e-09	2.5e-08	prevalence	1530	1060	6.77e-09	4.53e-08
Roseburia_inulinivorans	diagnosis	CD	diagnosisCD	0.148	0.198	1	1	abundance	1530	951	7.83e-09	5.21e-08
Roseburia_inulinivorans	diagnosis	CD	diagnosisCD	-0.883	0.15	3.92e-09	2.87e-08	prevalence	1530	951	7.83e-09	5.21e-08
Waltera_intestinalis	diagnosis	CD	diagnosisCD	-0.255	0.333	1	1	abundance	1530	524	7.99e-09	5.28e-08
Waltera_intestinalis	diagnosis	CD	diagnosisCD	-0.811	0.138	3.99e-09	2.91e-08	prevalence	1530	524	7.99e-09	5.28e-08
Alistipes_communis	diagnosis	UC	diagnosisUC	-1.04	0.337	0.000997	0.00586	abundance	1530	407	8.62e-09	5.66e-08
Alistipes_communis	diagnosis	UC	diagnosisUC	-1.03	0.176	4.31e-09	3.12e-08	prevalence	1530	407	8.62e-09	5.66e-08
Dysosmobacter_sp_BX15	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.83	0.724	8.06e-07	1.69e-05	abundance	1530	621	8.99e-09	5.86e-08
Dysosmobacter_sp_BX15	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.19	0.373	4.49e-09	3.23e-08	prevalence	1530	621	8.99e-09	5.86e-08
Clostridium_sp_AT4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	3.32	0.594	4.85e-09	1.9e-07	abundance	1530	528	9.7e-09	6.29e-08
Clostridium_sp_AT4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.06	0.273	0.000108	0.000353	prevalence	1530	528	9.7e-09	6.29e-08
Clostridium_sp_AT4	reads	reads	reads	-0.533	0.101	1	1	abundance	1530	528	1e-08	6.48e-08
Clostridium_sp_AT4	reads	reads	reads	0.342	0.0586	5.02e-09	3.59e-08	prevalence	1530	528	1e-08	6.48e-08
Coprococcus_comes	diagnosis	UC	diagnosisUC	1.29	0.206	5.26e-09	1.97e-07	abundance	1530	759	1.05e-08	6.74e-08
Coprococcus_comes	diagnosis	UC	diagnosisUC	-0.13	0.144	0.367	0.465	prevalence	1530	759	1.05e-08	6.74e-08
GGB33512_SGB15201	age	age	age	0.483	0.0844	1.08e-08	7.48e-08	prevalence	1530	121	1.08e-08	6.9e-08
Anaerostipes_hadrus	age	age	age	-0.359	0.0706	9.16e-07	1.87e-05	abundance	1530	1130	1.15e-08	7.29e-08
Anaerostipes_hadrus	age	age	age	-0.363	0.0624	5.76e-09	4.09e-08	prevalence	1530	1130	1.15e-08	7.29e-08
Eubacterium_ventriosum	diagnosis	CD	diagnosisCD	-0.0287	0.273	1	1	abundance	1530	520	1.24e-08	7.79e-08
Eubacterium_ventriosum	diagnosis	CD	diagnosisCD	-0.802	0.138	6.19e-09	4.36e-08	prevalence	1530	520	1.24e-08	7.79e-08
Eubacterium_siraeum	age	age	age	0.142	0.127	1	1	abundance	1530	565	1.26e-08	7.88e-08
Eubacterium_siraeum	age	age	age	0.326	0.0561	6.3e-09	4.41e-08	prevalence	1530	565	1.26e-08	7.88e-08
Enterocloster_clostridioformis	age	age	age	0.914	0.155	7.04e-09	2.53e-07	abundance	1530	312	1.41e-08	8.75e-08
Enterocloster_clostridioformis	age	age	age	0.345	0.063	4.47e-08	2.76e-07	prevalence	1530	312	1.41e-08	8.75e-08
Fusicatenibacter_saccharivorans	antibiotics	Yes	antibioticsYes	-0.154	0.269	1	1	abundance	1530	1120	1.51e-08	9.36e-08
Fusicatenibacter_saccharivorans	antibiotics	Yes	antibioticsYes	-1.16	0.2	7.57e-09	5.27e-08	prevalence	1530	1120	1.51e-08	9.36e-08
Lachnospira_eligens	reads	reads	reads	-0.57	0.0896	1	1	abundance	1530	929	2.47e-08	1.51e-07
Oscillospiraceae_bacterium	diagnosis	UC	diagnosisUC	-4.05	0.643	1.23e-08	4.26e-07	abundance	1530	81	2.46e-08	1.51e-07
Lachnospira_eligens	reads	reads	reads	0.342	0.06	1.24e-08	8.49e-08	prevalence	1530	929	2.47e-08	1.51e-07
Oscillospiraceae_bacterium	diagnosis	UC	diagnosisUC	-0.615	0.262	0.019	0.0373	prevalence	1530	81	2.46e-08	1.51e-07
Clostridium_leptum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.12	1.14	1	1	abundance	1530	652	2.73e-08	1.65e-07
Clostridium_sp_AF36_4	diagnosis	CD	diagnosisCD	0.369	0.211	0.0389	0.109	abundance	1530	568	2.72e-08	1.65e-07
Clostridium_leptum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.59	0.457	1.36e-08	9.24e-08	prevalence	1530	652	2.73e-08	1.65e-07
Clostridium_sp_AF36_4	diagnosis	CD	diagnosisCD	-0.776	0.137	1.36e-08	9.24e-08	prevalence	1530	568	2.72e-08	1.65e-07
Collinsella_aerofaciens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.224	0.572	0.439	0.702	abundance	1530	698	3.09e-08	1.85e-07
Collinsella_aerofaciens	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.5	0.266	1.54e-08	1.04e-07	prevalence	1530	698	3.09e-08	1.85e-07
Collinsella_SGB14861	diagnosis	UC	diagnosisUC	0.386	0.284	0.27	0.485	abundance	1530	593	3.7e-08	2.21e-07
Collinsella_SGB14861	diagnosis	UC	diagnosisUC	-0.843	0.15	1.85e-08	1.24e-07	prevalence	1530	593	3.7e-08	2.21e-07
Flavonifractor_plautii	diagnosis	CD	diagnosisCD	0.919	0.175	1.94e-08	6.48e-07	abundance	1530	1220	3.89e-08	2.31e-07
Flavonifractor_plautii	diagnosis	CD	diagnosisCD	0.692	0.177	8.97e-05	0.000297	prevalence	1530	1220	3.89e-08	2.31e-07
GGB9708_SGB15234	age	age	age	0.338	0.16	0.03	0.0895	abundance	1530	282	4.02e-08	2.37e-07
GGB9708_SGB15234	age	age	age	0.358	0.0637	2.01e-08	1.34e-07	prevalence	1530	282	4.02e-08	2.37e-07
Bacteroides_uniformis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.694	0.561	0.0508	0.136	abundance	1530	1240	4.33e-08	2.54e-07
Bacteroides_uniformis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.98	0.353	2.17e-08	1.43e-07	prevalence	1530	1240	4.33e-08	2.54e-07
Oscillibacter_sp_ER4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.89	0.878	0.00247	0.0123	abundance	1530	458	5.2e-08	3.04e-07
Oscillibacter_sp_ER4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.37	0.427	2.6e-08	1.71e-07	prevalence	1530	458	5.2e-08	3.04e-07
Bacteroides_uniformis	reads	reads	reads	-0.0532	0.069	3.01e-05	0.000323	abundance	1530	1240	5.32e-08	3.09e-07
Bacteroides_uniformis	reads	reads	reads	0.447	0.0803	2.66e-08	1.73e-07	prevalence	1530	1240	5.32e-08	3.09e-07
Eubacterium_siraeum	diagnosis	UC	diagnosisUC	-1.08	0.375	0.00222	0.0113	abundance	1530	565	5.42e-08	3.13e-07
Eubacterium_siraeum	diagnosis	UC	diagnosisUC	-0.838	0.151	2.71e-08	1.76e-07	prevalence	1530	565	5.42e-08	3.13e-07
Ruthenibacterium_lactatiformans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.879	0.531	0.0392	0.11	abundance	1530	797	5.49e-08	3.16e-07
Ruthenibacterium_lactatiformans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.33	0.24	2.75e-08	1.77e-07	prevalence	1530	797	5.49e-08	3.16e-07
Bilophila_wadsworthia	diagnosis	UC	diagnosisUC	0.457	0.226	0.0894	0.213	abundance	1530	764	5.59e-08	3.19e-07
Bilophila_wadsworthia	diagnosis	UC	diagnosisUC	-0.828	0.149	2.79e-08	1.79e-07	prevalence	1530	764	5.59e-08	3.19e-07
Enterocloster_bolteae	reads	reads	reads	-0.494	0.0968	1	1	abundance	1530	866	5.96e-08	3.39e-07
Enterocloster_bolteae	reads	reads	reads	0.313	0.0565	2.98e-08	1.9e-07	prevalence	1530	866	5.96e-08	3.39e-07
Parasutterella_excrementihominis	diagnosis	CD	diagnosisCD	1.21	0.249	3.53e-07	8.14e-06	abundance	1530	699	6.19e-08	3.5e-07
Parasutterella_excrementihominis	diagnosis	CD	diagnosisCD	-0.749	0.135	3.09e-08	1.96e-07	prevalence	1530	699	6.19e-08	3.5e-07
Enterocloster_bolteae	age	age	age	0.515	0.0942	3.14e-08	9.76e-07	abundance	1530	866	6.29e-08	3.53e-07
Enterocloster_bolteae	age	age	age	-0.0852	0.0538	0.113	0.175	prevalence	1530	866	6.29e-08	3.53e-07
Proteus_mirabilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	3.55	0.985	0.000236	0.00174	abundance	1530	100	6.4e-08	3.58e-07
Proteus_mirabilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.81	0.327	3.2e-08	2.01e-07	prevalence	1530	100	6.4e-08	3.58e-07
GGB3746_SGB5089	antibiotics	Yes	antibioticsYes	-0.454	0.528	0.47	0.741	abundance	1530	651	6.75e-08	3.75e-07
GGB3746_SGB5089	antibiotics	Yes	antibioticsYes	-1.28	0.232	3.37e-08	2.11e-07	prevalence	1530	651	6.75e-08	3.75e-07
Parasutterella_SGB9260	diagnosis	UC	diagnosisUC	1.7	0.357	7.72e-06	0.000109	abundance	1530	269	7.06e-08	3.91e-07
Parasutterella_SGB9260	diagnosis	UC	diagnosisUC	1.01	0.183	3.53e-08	2.2e-07	prevalence	1530	269	7.06e-08	3.91e-07
Anaerostipes_hadrus	diagnosis	UC	diagnosisUC	1.07	0.181	4.01e-08	1.2e-06	abundance	1530	1130	8.02e-08	4.41e-07
Anaerostipes_hadrus	diagnosis	UC	diagnosisUC	-0.367	0.184	0.0463	0.0813	prevalence	1530	1130	8.02e-08	4.41e-07
Clostridium_sp_AF34_10BH	diagnosis	UC	diagnosisUC	-0.476	0.226	0.0157	0.0543	abundance	1530	960	9.62e-08	5.27e-07
Clostridium_sp_AF34_10BH	diagnosis	UC	diagnosisUC	-0.92	0.169	4.81e-08	2.95e-07	prevalence	1530	960	9.62e-08	5.27e-07
Akkermansia_sp_KLE1798	diagnosis	CD	diagnosisCD	-1.52	0.285	9.85e-08	5.82e-07	prevalence	1530	70	9.85e-08	5.37e-07
Clostridium_sp_AF36_4	diagnosis	UC	diagnosisUC	0.107	0.231	1	1	abundance	1530	568	1.26e-07	6.81e-07
Clostridium_sp_AF36_4	diagnosis	UC	diagnosisUC	-0.802	0.148	6.29e-08	3.82e-07	prevalence	1530	568	1.26e-07	6.81e-07
Roseburia_hominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.44	0.524	0.00161	0.00875	abundance	1530	876	1.38e-07	7.46e-07
Roseburia_hominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.27	0.236	6.91e-08	4.18e-07	prevalence	1530	876	1.38e-07	7.46e-07
Faecalibacterium_SGB15315	diagnosis	CD	diagnosisCD	1	0.3	0.000394	0.00267	abundance	1530	619	1.42e-07	7.64e-07
Faecalibacterium_SGB15315	diagnosis	CD	diagnosisCD	-0.74	0.137	7.12e-08	4.28e-07	prevalence	1530	619	1.42e-07	7.64e-07
Roseburia_faecis	age	age	age	-0.125	0.0887	1	1	abundance	1530	922	1.52e-07	8.12e-07
Roseburia_faecis	age	age	age	0.314	0.0585	7.61e-08	4.54e-07	prevalence	1530	922	1.52e-07	8.12e-07
Clostridium_sp_AT4	diagnosis	CD	diagnosisCD	0.3	0.311	0.235	0.44	abundance	1530	528	1.57e-07	8.31e-07
Clostridium_sp_AT4	diagnosis	CD	diagnosisCD	0.814	0.152	7.83e-08	4.65e-07	prevalence	1530	528	1.57e-07	8.31e-07
Fusicatenibacter_saccharivorans	reads	reads	reads	-0.451	0.0701	1	1	abundance	1530	1120	2.07e-07	1.09e-06
Fusicatenibacter_saccharivorans	reads	reads	reads	0.367	0.0689	1.04e-07	6.08e-07	prevalence	1530	1120	2.07e-07	1.09e-06
Lactobacillus_acidophilus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.35	0.453	2.16e-07	1.19e-06	prevalence	1530	26	2.16e-07	1.13e-06
Dysosmobacter_welbionis	diagnosis	CD	diagnosisCD	0.726	0.149	1.11e-07	3.11e-06	abundance	1530	1190	2.21e-07	1.16e-06
Dysosmobacter_welbionis	diagnosis	CD	diagnosisCD	0.492	0.179	0.00607	0.0135	prevalence	1530	1190	2.21e-07	1.16e-06
Lacrimispora_amygdalina	reads	reads	reads	-0.318	0.077	1	1	abundance	1530	865	2.23e-07	1.16e-06
Lacrimispora_amygdalina	reads	reads	reads	0.313	0.0591	1.12e-07	6.52e-07	prevalence	1530	865	2.23e-07	1.16e-06
Alistipes_communis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.06	0.805	0.295	0.52	abundance	1530	407	2.34e-07	1.21e-06
Alistipes_communis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2	0.378	1.17e-07	6.79e-07	prevalence	1530	407	2.34e-07	1.21e-06
Eubacterium_rectale	age	age	age	-0.357	0.065	1.21e-07	3.3e-06	abundance	1530	1210	2.42e-07	1.25e-06
Eubacterium_rectale	age	age	age	0.199	0.0773	0.00995	0.021	prevalence	1530	1210	2.42e-07	1.25e-06
GGB3746_SGB5089	reads	reads	reads	-0.538	0.109	1	1	abundance	1530	651	2.65e-07	1.36e-06
GGB3746_SGB5089	reads	reads	reads	0.304	0.0575	1.33e-07	7.66e-07	prevalence	1530	651	2.65e-07	1.36e-06
Roseburia_hominis	diagnosis	CD	diagnosisCD	-0.339	0.206	0.189	0.377	abundance	1530	876	2.72e-07	1.39e-06
Roseburia_hominis	diagnosis	CD	diagnosisCD	-0.78	0.148	1.36e-07	7.82e-07	prevalence	1530	876	2.72e-07	1.39e-06
Roseburia_inulinivorans	reads	reads	reads	-0.114	0.0856	1	1	abundance	1530	951	2.93e-07	1.49e-06
Roseburia_inulinivorans	reads	reads	reads	0.32	0.0609	1.47e-07	8.38e-07	prevalence	1530	951	2.93e-07	1.49e-06
Bacteroides_stercoris	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.494	1.3	0.489	0.766	abundance	1530	826	2.98e-07	1.51e-06
Bacteroides_stercoris	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.37	0.451	1.49e-07	8.46e-07	prevalence	1530	826	2.98e-07	1.51e-06
Clostridium_sp_AF34_10BH	antibiotics	Yes	antibioticsYes	-0.437	0.381	0.339	0.58	abundance	1530	960	3e-07	1.51e-06
Clostridium_sp_AF34_10BH	antibiotics	Yes	antibioticsYes	-1.05	0.199	1.5e-07	8.48e-07	prevalence	1530	960	3e-07	1.51e-06
Collinsella_aerofaciens	diagnosis	UC	diagnosisUC	1.36	0.242	1.54e-07	4.08e-06	abundance	1530	698	3.08e-07	1.54e-06
Collinsella_aerofaciens	diagnosis	UC	diagnosisUC	0.132	0.143	0.357	0.455	prevalence	1530	698	3.08e-07	1.54e-06
Oscillospiraceae_bacterium	diagnosis	CD	diagnosisCD	-3.76	1.05	0.000761	0.00466	abundance	1530	81	3.33e-07	1.66e-06
Oscillospiraceae_bacterium	diagnosis	CD	diagnosisCD	-2.05	0.392	1.66e-07	9.36e-07	prevalence	1530	81	3.33e-07	1.66e-06
Bacteroides_salyersiae	age	age	age	1.16	0.212	1.78e-07	4.59e-06	abundance	1530	150	3.57e-07	1.77e-06
Bacteroides_salyersiae	age	age	age	0.38	0.0805	2.41e-06	1.17e-05	prevalence	1530	150	3.57e-07	1.77e-06
Faecalibacterium_SGB15315	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.42	1.53	0.149	0.315	abundance	1530	619	3.73e-07	1.84e-06
Faecalibacterium_SGB15315	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.62	0.503	1.87e-07	1.04e-06	prevalence	1530	619	3.73e-07	1.84e-06
Fusicatenibacter_saccharivorans	diagnosis	UC	diagnosisUC	0.676	0.178	0.000719	0.00446	abundance	1530	1120	4.01e-07	1.97e-06
Fusicatenibacter_saccharivorans	diagnosis	UC	diagnosisUC	-0.969	0.186	2e-07	1.11e-06	prevalence	1530	1120	4.01e-07	1.97e-06
Ruminococcus_bromii	age	age	age	0.0414	0.115	1	1	abundance	1530	429	4.83e-07	2.36e-06
Ruminococcus_bromii	age	age	age	0.298	0.0577	2.41e-07	1.33e-06	prevalence	1530	429	4.83e-07	2.36e-06
Parabacteroides_merdae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.28	0.976	0.00608	0.0256	abundance	1530	826	4.88e-07	2.38e-06
Parabacteroides_merdae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.5	0.485	2.44e-07	1.34e-06	prevalence	1530	826	4.88e-07	2.38e-06
Parasutterella_SGB9260	diagnosis	CD	diagnosisCD	1.94	0.38	2.48e-07	6.19e-06	abundance	1530	269	4.95e-07	2.4e-06
Parasutterella_SGB9260	diagnosis	CD	diagnosisCD	0.191	0.186	0.306	0.402	prevalence	1530	269	4.95e-07	2.4e-06
GGB6601_SGB9333	age	age	age	0.533	0.107	5.67e-07	2.98e-06	prevalence	1530	69	5.67e-07	2.74e-06
Lacrimispora_celerecrescens	age	age	age	-0.36	0.0867	6.32e-05	0.000599	abundance	1530	756	6.19e-07	2.97e-06
Lacrimispora_celerecrescens	age	age	age	-0.284	0.0554	3.09e-07	1.69e-06	prevalence	1530	756	6.19e-07	2.97e-06
Ruminococcus_torques	diagnosis	CD	diagnosisCD	0.879	0.184	3.25e-07	7.74e-06	abundance	1530	1090	6.49e-07	3.11e-06
Ruminococcus_torques	diagnosis	CD	diagnosisCD	-0.696	0.164	2.15e-05	8.32e-05	prevalence	1530	1090	6.49e-07	3.11e-06
Parabacteroides_distasonis	reads	reads	reads	-0.032	0.0603	3.27e-07	7.74e-06	abundance	1530	1140	6.54e-07	3.11e-06
Parabacteroides_distasonis	reads	reads	reads	0.211	0.0671	0.00166	0.00425	prevalence	1530	1140	6.54e-07	3.11e-06
Akkermansia_muciniphila	diagnosis	UC	diagnosisUC	-0.356	0.456	0.349	0.588	abundance	1530	407	7.71e-07	3.64e-06
GGB9708_SGB15234	diagnosis	UC	diagnosisUC	0.652	0.488	0.236	0.441	abundance	1530	282	7.71e-07	3.64e-06
Akkermansia_muciniphila	diagnosis	UC	diagnosisUC	-0.842	0.166	3.85e-07	2.08e-06	prevalence	1530	407	7.71e-07	3.64e-06
GGB9708_SGB15234	diagnosis	UC	diagnosisUC	-0.96	0.189	3.85e-07	2.08e-06	prevalence	1530	282	7.71e-07	3.64e-06
Dorea_longicatena	diagnosis	UC	diagnosisUC	1.01	0.184	3.91e-07	8.8e-06	abundance	1530	1020	7.83e-07	3.68e-06
Dorea_longicatena	diagnosis	UC	diagnosisUC	-0.123	0.16	0.443	0.546	prevalence	1530	1020	7.83e-07	3.68e-06
Prevotella_copri_clade_A	age	age	age	-0.551	0.348	0.122	0.272	abundance	1530	289	8.08e-07	3.78e-06
Prevotella_copri_clade_A	age	age	age	-0.387	0.0763	4.04e-07	2.17e-06	prevalence	1530	289	8.08e-07	3.78e-06
Faecalibacterium_SGB15346	reads	reads	reads	-0.678	0.0997	0.000798	0.00485	abundance	1530	743	9.04e-07	4.21e-06
Faecalibacterium_SGB15346	reads	reads	reads	0.287	0.057	4.52e-07	2.41e-06	prevalence	1530	743	9.04e-07	4.21e-06
Bacteroides_xylanisolvens	reads	reads	reads	-0.56	0.118	1	1	abundance	1530	959	9.5e-07	4.41e-06
Bacteroides_xylanisolvens	reads	reads	reads	0.302	0.0599	4.75e-07	2.52e-06	prevalence	1530	959	9.5e-07	4.41e-06
Candidatus_Cibionibacter_quicibialis	reads	reads	reads	-0.348	0.0873	1	1	abundance	1530	933	1.02e-06	4.7e-06
Candidatus_Cibionibacter_quicibialis	reads	reads	reads	0.299	0.0596	5.09e-07	2.69e-06	prevalence	1530	933	1.02e-06	4.7e-06
Oscillibacter_sp_ER4	diagnosis	UC	diagnosisUC	0.131	0.267	1	1	abundance	1530	458	1.23e-06	5.67e-06
Oscillibacter_sp_ER4	diagnosis	UC	diagnosisUC	-0.789	0.158	6.17e-07	3.23e-06	prevalence	1530	458	1.23e-06	5.67e-06
Bacteroides_stercoris	age	age	age	-0.602	0.118	6.64e-07	1.46e-05	abundance	1530	826	1.33e-06	6.06e-06
Blautia_wexlerae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.546	0.508	1	1	abundance	1530	1300	1.33e-06	6.06e-06
Bacteroides_stercoris	age	age	age	-0.0954	0.054	0.0772	0.125	prevalence	1530	826	1.33e-06	6.06e-06
Blautia_wexlerae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.86	0.373	6.65e-07	3.46e-06	prevalence	1530	1300	1.33e-06	6.06e-06
Roseburia_inulinivorans	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.309	0.754	0.345	0.586	abundance	1530	951	1.37e-06	6.23e-06
Roseburia_inulinivorans	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.87	0.377	6.87e-07	3.56e-06	prevalence	1530	951	1.37e-06	6.23e-06
Phocaeicola_plebeius	diagnosis	CD	diagnosisCD	-3.91	0.732	6.98e-07	1.49e-05	abundance	1530	127	1.4e-06	6.3e-06
Phocaeicola_plebeius	diagnosis	CD	diagnosisCD	0.3	0.271	0.269	0.36	prevalence	1530	127	1.4e-06	6.3e-06
Clostridium_sp_AF36_4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.465	0.723	1	1	abundance	1530	568	1.63e-06	7.34e-06
Clostridium_sp_AF36_4	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.76	0.358	8.16e-07	4.21e-06	prevalence	1530	568	1.63e-06	7.34e-06
Eisenbergiella_massiliensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.47	0.947	0.0048	0.021	abundance	1530	417	1.89e-06	8.45e-06
GGB33469_SGB15236	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-6.45	1.24	9.48e-07	1.88e-05	abundance	1530	293	1.9e-06	8.45e-06
Eisenbergiella_massiliensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.61	0.329	9.47e-07	4.86e-06	prevalence	1530	417	1.89e-06	8.45e-06
GGB33469_SGB15236	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.97	0.51	0.000108	0.000353	prevalence	1530	293	1.9e-06	8.45e-06
Phascolarctobacterium_succinatutens	diagnosis	CD	diagnosisCD	-0.728	0.387	0.0914	0.216	abundance	1530	125	1.91e-06	8.46e-06
Phascolarctobacterium_succinatutens	diagnosis	CD	diagnosisCD	-1.25	0.256	9.53e-07	4.87e-06	prevalence	1530	125	1.91e-06	8.46e-06
Bacteroides_cellulosilyticus	diagnosis	UC	diagnosisUC	-1.76	0.369	9.59e-07	1.88e-05	abundance	1530	433	1.92e-06	8.49e-06
Bacteroides_cellulosilyticus	diagnosis	UC	diagnosisUC	-0.344	0.158	0.0289	0.0542	prevalence	1530	433	1.92e-06	8.49e-06
Gemmiger_formicilis	antibiotics	Yes	antibioticsYes	0.386	0.356	0.199	0.392	abundance	1530	472	1.94e-06	8.54e-06
Gemmiger_formicilis	antibiotics	Yes	antibioticsYes	0.938	0.191	9.7e-07	4.93e-06	prevalence	1530	472	1.94e-06	8.54e-06
Ruminococcus_torques	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.213	0.686	1	1	abundance	1530	1090	2.16e-06	9.49e-06
Ruminococcus_torques	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.74	0.357	1.08e-06	5.47e-06	prevalence	1530	1090	2.16e-06	9.49e-06
Blautia_faecis	diagnosis	UC	diagnosisUC	0.985	0.186	1.11e-06	2.13e-05	abundance	1530	1120	2.22e-06	9.71e-06
Blautia_faecis	diagnosis	UC	diagnosisUC	0.336	0.179	0.0602	0.101	prevalence	1530	1120	2.22e-06	9.71e-06
Blautia_wexlerae	age	age	age	-0.122	0.0687	1	1	abundance	1530	1300	2.27e-06	9.87e-06
Blautia_wexlerae	age	age	age	-0.367	0.0755	1.13e-06	5.71e-06	prevalence	1530	1300	2.27e-06	9.87e-06
Dorea_longicatena	antibiotics	Yes	antibioticsYes	-0.0691	0.274	1	1	abundance	1530	1020	2.4e-06	1.04e-05
Dorea_longicatena	antibiotics	Yes	antibioticsYes	-0.902	0.186	1.2e-06	6.02e-06	prevalence	1530	1020	2.4e-06	1.04e-05
Akkermansia_sp_KLE1798	diagnosis	UC	diagnosisUC	-2.86	0.609	2.62e-06	1.26e-05	prevalence	1530	70	2.62e-06	1.13e-05
Blautia_obeum	diagnosis	CD	diagnosisCD	0.954	0.21	1.37e-06	2.58e-05	abundance	1530	899	2.75e-06	1.18e-05
Blautia_obeum	diagnosis	CD	diagnosisCD	0.105	0.137	0.445	0.548	prevalence	1530	899	2.75e-06	1.18e-05
Bifidobacterium_longum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.462	0.819	1	1	abundance	1530	843	2.81e-06	1.2e-05
Phocaeicola_dorei	age	age	age	0.524	0.189	0.00485	0.021	abundance	1530	769	2.81e-06	1.2e-05
Bifidobacterium_longum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.8	0.374	1.41e-06	6.95e-06	prevalence	1530	843	2.81e-06	1.2e-05
Phocaeicola_dorei	age	age	age	0.27	0.0561	1.4e-06	6.95e-06	prevalence	1530	769	2.81e-06	1.2e-05
Bacteroides_caccae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.543	0.776	1	1	abundance	1530	958	3.03e-06	1.29e-05
Bacteroides_caccae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.95	0.406	1.52e-06	7.45e-06	prevalence	1530	958	3.03e-06	1.29e-05
Lacrimispora_amygdalina	diagnosis	UC	diagnosisUC	0.987	0.189	1.64e-06	3.02e-05	abundance	1530	865	3.28e-06	1.39e-05
Lacrimispora_amygdalina	diagnosis	UC	diagnosisUC	-0.0931	0.155	0.548	0.64	prevalence	1530	865	3.28e-06	1.39e-05
Bacteroides_finegoldii	antibiotics	Yes	antibioticsYes	2.7	0.571	1.92e-06	3.45e-05	abundance	1530	333	3.83e-06	1.61e-05
Bacteroides_finegoldii	antibiotics	Yes	antibioticsYes	0.926	0.212	1.26e-05	5.2e-05	prevalence	1530	333	3.83e-06	1.61e-05
Clostridium_sp_AF34_10BH	diagnosis	CD	diagnosisCD	-0.596	0.208	0.0114	0.042	abundance	1530	960	3.86e-06	1.62e-05
Clostridium_sp_AF34_10BH	diagnosis	CD	diagnosisCD	-0.758	0.159	1.93e-06	9.44e-06	prevalence	1530	960	3.86e-06	1.62e-05
Clostridiaceae_bacterium	diagnosis	UC	diagnosisUC	0.456	0.175	0.0286	0.0857	abundance	1530	1110	4.16e-06	1.74e-05
Clostridiaceae_bacterium	diagnosis	UC	diagnosisUC	-0.893	0.188	2.08e-06	1.01e-05	prevalence	1530	1110	4.16e-06	1.74e-05
Phocaeicola_plebeius	diagnosis	UC	diagnosisUC	-3.67	0.751	2.19e-06	3.87e-05	abundance	1530	127	4.39e-06	1.83e-05
Phocaeicola_plebeius	diagnosis	UC	diagnosisUC	1.01	0.257	8.8e-05	0.000292	prevalence	1530	127	4.39e-06	1.83e-05
Escherichia_coli	antibiotics	Yes	antibioticsYes	2.02	0.439	2.33e-06	4.03e-05	abundance	1530	707	4.65e-06	1.93e-05
Escherichia_coli	antibiotics	Yes	antibioticsYes	-0.746	0.193	0.000111	0.00036	prevalence	1530	707	4.65e-06	1.93e-05
Flavonifractor_plautii	diagnosis	UC	diagnosisUC	0.973	0.19	2.43e-06	4.12e-05	abundance	1530	1220	4.86e-06	2.01e-05
Flavonifractor_plautii	diagnosis	UC	diagnosisUC	0.752	0.189	6.76e-05	0.000231	prevalence	1530	1220	4.86e-06	2.01e-05
Barnesiella_intestinihominis	diagnosis	UC	diagnosisUC	-1.17	0.317	0.000104	0.000887	abundance	1530	431	5.04e-06	2.07e-05
Barnesiella_intestinihominis	diagnosis	UC	diagnosisUC	-0.736	0.156	2.52e-06	1.22e-05	prevalence	1530	431	5.04e-06	2.07e-05
Eubacterium_ventriosum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.12	1.26	0.133	0.29	abundance	1530	520	5.25e-06	2.15e-05
Eubacterium_ventriosum	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.36	0.503	2.63e-06	1.26e-05	prevalence	1530	520	5.25e-06	2.15e-05
Clostridium_leptum	diagnosis	CD	diagnosisCD	-0.89	0.24	0.000659	0.00412	abundance	1530	652	5.48e-06	2.24e-05
Clostridium_leptum	diagnosis	CD	diagnosisCD	-0.635	0.135	2.74e-06	1.3e-05	prevalence	1530	652	5.48e-06	2.24e-05
Phocaeicola_coprocola	diagnosis	UC	diagnosisUC	5.27	2.45	0.0367	0.105	abundance	1530	101	5.59e-06	2.27e-05
Phocaeicola_coprocola	diagnosis	UC	diagnosisUC	2.86	0.61	2.79e-06	1.32e-05	prevalence	1530	101	5.59e-06	2.27e-05
Bacteroides_cellulosilyticus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.78	1.02	0.0122	0.0446	abundance	1530	433	5.61e-06	2.27e-05
Bacteroides_cellulosilyticus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.7	0.363	2.81e-06	1.32e-05	prevalence	1530	433	5.61e-06	2.27e-05
Lachnospira_eligens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.965	0.763	0.462	0.731	abundance	1530	929	5.67e-06	2.29e-05
Lachnospira_eligens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.71	0.365	2.84e-06	1.33e-05	prevalence	1530	929	5.67e-06	2.29e-05
Clostridiaceae_bacterium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.11	0.639	0.646	0.967	abundance	1530	1110	5.72e-06	2.3e-05
Clostridiaceae_bacterium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.74	0.372	2.86e-06	1.34e-05	prevalence	1530	1110	5.72e-06	2.3e-05
GGB3278_SGB4328	diagnosis	CD	diagnosisCD	-0.827	0.493	0.126	0.278	abundance	1530	179	6.32e-06	2.53e-05
GGB3278_SGB4328	diagnosis	CD	diagnosisCD	-0.905	0.194	3.16e-06	1.47e-05	prevalence	1530	179	6.32e-06	2.53e-05
Flavonifractor_plautii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.2	0.303	3.27e-06	5.35e-05	abundance	1530	1220	6.54e-06	2.61e-05
Flavonifractor_plautii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.06	0.233	5.52e-06	2.47e-05	prevalence	1530	1220	6.54e-06	2.61e-05
Anaerostipes_hadrus	diagnosis	CD	diagnosisCD	0.702	0.166	3.59e-06	5.77e-05	abundance	1530	1130	7.18e-06	2.85e-05
Anaerostipes_hadrus	diagnosis	CD	diagnosisCD	-0.349	0.175	0.0463	0.0813	prevalence	1530	1130	7.18e-06	2.85e-05
Alistipes_onderdonkii	diagnosis	CD	diagnosisCD	-0.121	0.23	1	1	abundance	1530	831	7.61e-06	3.01e-05
Alistipes_onderdonkii	diagnosis	CD	diagnosisCD	-0.658	0.142	3.8e-06	1.76e-05	prevalence	1530	831	7.61e-06	3.01e-05
GGB9480_SGB14874	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.14	1.11	0.221	0.424	abundance	1530	332	8.17e-06	3.22e-05
GGB9480_SGB14874	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.32	0.504	4.09e-06	1.88e-05	prevalence	1530	332	8.17e-06	3.22e-05
Phocaeicola_coprocola	diagnosis	CD	diagnosisCD	5.7	2.41	0.0186	0.0611	abundance	1530	101	8.36e-06	3.29e-05
Phocaeicola_coprocola	diagnosis	CD	diagnosisCD	2.79	0.607	4.18e-06	1.91e-05	prevalence	1530	101	8.36e-06	3.29e-05
Acidaminococcus_intestini	age	age	age	0.629	0.174	0.00032	0.00221	abundance	1530	173	8.57e-06	3.35e-05
Barnesiella_intestinihominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.96	1.04	0.00877	0.0345	abundance	1530	431	8.58e-06	3.35e-05
Acidaminococcus_intestini	age	age	age	0.36	0.0782	4.28e-06	1.95e-05	prevalence	1530	173	8.57e-06	3.35e-05
Barnesiella_intestinihominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.95	0.425	4.29e-06	1.95e-05	prevalence	1530	431	8.58e-06	3.35e-05
Parasutterella_excrementihominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.06	0.627	0.0428	0.117	abundance	1530	699	8.85e-06	3.44e-05
Parasutterella_excrementihominis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.24	0.269	4.43e-06	2e-05	prevalence	1530	699	8.85e-06	3.44e-05
Dysosmobacter_sp_BX15	diagnosis	UC	diagnosisUC	-0.909	0.212	4.63e-06	7.31e-05	abundance	1530	621	9.27e-06	3.59e-05
Dysosmobacter_sp_BX15	diagnosis	UC	diagnosisUC	-0.629	0.146	1.61e-05	6.36e-05	prevalence	1530	621	9.27e-06	3.59e-05
Clostridiales_bacterium	age	age	age	-0.0272	0.0766	1	1	abundance	1530	985	1.01e-05	3.89e-05
Clostridiales_bacterium	age	age	age	0.291	0.0639	5.05e-06	2.27e-05	prevalence	1530	985	1.01e-05	3.89e-05
Lacrimispora_celerecrescens	reads	reads	reads	-0.405	0.0814	1	1	abundance	1530	756	1.12e-05	4.32e-05
Lacrimispora_celerecrescens	reads	reads	reads	0.257	0.0566	5.62e-06	2.51e-05	prevalence	1530	756	1.12e-05	4.32e-05
Coprococcus_comes	diagnosis	CD	diagnosisCD	0.823	0.195	5.66e-06	8.64e-05	abundance	1530	759	1.13e-05	4.34e-05
Coprococcus_comes	diagnosis	CD	diagnosisCD	-0.143	0.134	0.288	0.384	prevalence	1530	759	1.13e-05	4.34e-05
Bacteroides_xylanisolvens	age	age	age	0.122	0.126	1	1	abundance	1530	959	1.15e-05	4.38e-05
Bacteroides_xylanisolvens	age	age	age	-0.253	0.0558	5.74e-06	2.55e-05	prevalence	1530	959	1.15e-05	4.38e-05
Clostridiales_bacterium	diagnosis	UC	diagnosisUC	0.971	0.197	5.96e-06	8.94e-05	abundance	1530	985	1.19e-05	4.53e-05
Clostridiales_bacterium	diagnosis	UC	diagnosisUC	-0.626	0.165	0.000153	0.000487	prevalence	1530	985	1.19e-05	4.53e-05
Prevotella_copri_clade_B	age	age	age	2.92	0.546	6.36e-06	9.38e-05	abundance	1530	40	1.27e-05	4.82e-05
Prevotella_copri_clade_B	age	age	age	0.282	0.139	0.0426	0.0754	prevalence	1530	40	1.27e-05	4.82e-05
GGB33469_SGB15236	diagnosis	CD	diagnosisCD	0.936	0.341	0.00348	0.0162	abundance	1530	293	1.28e-05	4.82e-05
GGB33469_SGB15236	diagnosis	CD	diagnosisCD	-0.707	0.157	6.38e-06	2.82e-05	prevalence	1530	293	1.28e-05	4.82e-05
Veillonella_rogosae	age	age	age	0.137	0.265	1	1	abundance	1530	207	1.28e-05	4.82e-05
Veillonella_rogosae	age	age	age	-0.408	0.0903	6.41e-06	2.82e-05	prevalence	1530	207	1.28e-05	4.82e-05
Roseburia_intestinalis	antibiotics	Yes	antibioticsYes	-1.52	0.456	0.00154	0.00858	abundance	1530	842	1.31e-05	4.91e-05
Roseburia_intestinalis	antibiotics	Yes	antibioticsYes	-0.838	0.186	6.56e-06	2.87e-05	prevalence	1530	842	1.31e-05	4.91e-05
Clostridium_sp_AM22_11AC	diagnosis	CD	diagnosisCD	1	0.235	6.59e-06	9.57e-05	abundance	1530	730	1.32e-05	4.92e-05
Clostridium_sp_AM22_11AC	diagnosis	CD	diagnosisCD	-0.312	0.134	0.0203	0.0394	prevalence	1530	730	1.32e-05	4.92e-05
Faecalibacterium_SGB15315	age	age	age	-0.199	0.137	1	1	abundance	1530	619	1.33e-05	4.93e-05
Faecalibacterium_SGB15315	age	age	age	-0.262	0.0581	6.63e-06	2.9e-05	prevalence	1530	619	1.33e-05	4.93e-05
GGB1680_SGB2312	age	age	age	1.17	0.269	1.4e-05	5.68e-05	prevalence	1530	12	1.4e-05	5.19e-05
Bacteroides_salyersiae	reads	reads	reads	-0.0485	0.223	0.19	0.377	abundance	1530	150	1.47e-05	5.45e-05
Bacteroides_salyersiae	reads	reads	reads	0.377	0.084	7.37e-06	3.21e-05	prevalence	1530	150	1.47e-05	5.45e-05
Faecalibacterium_SGB15315	diagnosis	UC	diagnosisUC	0.621	0.318	0.0851	0.204	abundance	1530	619	1.5e-05	5.51e-05
Faecalibacterium_SGB15315	diagnosis	UC	diagnosisUC	-0.663	0.148	7.48e-06	3.24e-05	prevalence	1530	619	1.5e-05	5.51e-05
Clostridium_sp_AF36_4	age	age	age	0.0762	0.0837	1	1	abundance	1530	568	1.51e-05	5.54e-05
Clostridium_sp_AF36_4	age	age	age	0.25	0.0559	7.54e-06	3.25e-05	prevalence	1530	568	1.51e-05	5.54e-05
Waltera_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.7	1.13	0.189	0.377	abundance	1530	524	1.52e-05	5.56e-05
Waltera_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.68	0.375	7.6e-06	3.27e-05	prevalence	1530	524	1.52e-05	5.56e-05
Alistipes_dispar	antibiotics	Yes	antibioticsYes	4.67	0.987	7.77e-06	0.000109	abundance	1530	83	1.55e-05	5.66e-05
Alistipes_dispar	antibiotics	Yes	antibioticsYes	0.616	0.323	0.0562	0.0967	prevalence	1530	83	1.55e-05	5.66e-05
Vescimonas_coprocola	reads	reads	reads	-0.578	0.107	1	1	abundance	1530	599	1.75e-05	6.37e-05
Vescimonas_coprocola	reads	reads	reads	0.259	0.0583	8.76e-06	3.73e-05	prevalence	1530	599	1.75e-05	6.37e-05
Bacteroides_thetaiotaomicron	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.3	0.84	0.0428	0.117	abundance	1530	1060	1.8e-05	6.52e-05
Bacteroides_thetaiotaomicron	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.59	0.359	9.01e-06	3.83e-05	prevalence	1530	1060	1.8e-05	6.52e-05
Bacteroides_ovatus	reads	reads	reads	-0.00272	0.0761	9.2e-06	0.000126	abundance	1530	1180	1.84e-05	6.64e-05
Bacteroides_ovatus	reads	reads	reads	0.278	0.0713	9.5e-05	0.000312	prevalence	1530	1180	1.84e-05	6.64e-05
Alistipes_putredinis	age	age	age	-0.304	0.0798	0.000253	0.00184	abundance	1530	873	1.9e-05	6.84e-05
Alistipes_putredinis	age	age	age	0.265	0.0599	9.51e-06	4.02e-05	prevalence	1530	873	1.9e-05	6.84e-05
Phocaeicola_massiliensis	diagnosis	UC	diagnosisUC	-1.64	0.381	9.67e-06	0.00013	abundance	1530	396	1.93e-05	6.93e-05
Phocaeicola_massiliensis	diagnosis	UC	diagnosisUC	0.176	0.152	0.246	0.335	prevalence	1530	396	1.93e-05	6.93e-05
Parasutterella_excrementihominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.87	0.976	0.134	0.29	abundance	1530	699	1.95e-05	6.95e-05
Parasutterella_excrementihominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.88	0.426	9.74e-06	4.1e-05	prevalence	1530	699	1.95e-05	6.95e-05
Parabacteroides_merdae	age	age	age	-0.358	0.0783	1.06e-05	0.00014	abundance	1530	826	2.11e-05	7.51e-05
Parabacteroides_merdae	age	age	age	-0.11	0.054	0.0411	0.0731	prevalence	1530	826	2.11e-05	7.51e-05
Clostridium_fessum	diagnosis	CD	diagnosisCD	0.671	0.168	1.15e-05	0.00015	abundance	1530	926	2.29e-05	8.11e-05
Fusicatenibacter_saccharivorans	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.32	0.643	0.155	0.324	abundance	1530	1120	2.3e-05	8.11e-05
Vescimonas_coprocola	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.55	0.824	0.687	1	abundance	1530	599	2.29e-05	8.11e-05
Clostridium_fessum	diagnosis	CD	diagnosisCD	-0.443	0.153	0.00374	0.00876	prevalence	1530	926	2.29e-05	8.11e-05
Fusicatenibacter_saccharivorans	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.63	0.372	1.15e-05	4.81e-05	prevalence	1530	1120	2.3e-05	8.11e-05
Vescimonas_coprocola	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.39	0.317	1.14e-05	4.8e-05	prevalence	1530	599	2.29e-05	8.11e-05
Bacteroides_uniformis	diagnosis	CD	diagnosisCD	0.457	0.171	0.00212	0.011	abundance	1530	1240	2.33e-05	8.16e-05
Roseburia_sp_AF02_12	reads	reads	reads	-0.318	0.174	1	1	abundance	1530	363	2.33e-05	8.16e-05
Bacteroides_uniformis	diagnosis	CD	diagnosisCD	0.865	0.197	1.16e-05	4.83e-05	prevalence	1530	1240	2.33e-05	8.16e-05
Roseburia_sp_AF02_12	reads	reads	reads	0.289	0.066	1.17e-05	4.83e-05	prevalence	1530	363	2.33e-05	8.16e-05
Coprococcus_comes	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.43	1.07	0.00845	0.0334	abundance	1530	759	2.34e-05	8.17e-05
Coprococcus_comes	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.33	0.531	1.17e-05	4.84e-05	prevalence	1530	759	2.34e-05	8.17e-05
Oscillibacter_sp_ER4	antibiotics	Yes	antibioticsYes	-1.55	0.335	1.2e-05	0.000155	abundance	1530	458	2.41e-05	8.37e-05
Oscillibacter_sp_ER4	antibiotics	Yes	antibioticsYes	0.371	0.198	0.0608	0.102	prevalence	1530	458	2.41e-05	8.37e-05
Lachnospira_eligens	age	age	age	0.365	0.0855	1.22e-05	0.000155	abundance	1530	929	2.44e-05	8.47e-05
Lachnospira_eligens	age	age	age	0.202	0.0585	0.000543	0.00151	prevalence	1530	929	2.44e-05	8.47e-05
Odoribacter_splanchnicus	antibiotics	Yes	antibioticsYes	0.425	0.207	0.0164	0.0557	abundance	1530	757	2.65e-05	9.16e-05
Odoribacter_splanchnicus	antibiotics	Yes	antibioticsYes	0.877	0.201	1.33e-05	5.41e-05	prevalence	1530	757	2.65e-05	9.16e-05
Alistipes_putredinis	diagnosis	CD	diagnosisCD	-0.585	0.191	0.00685	0.0283	abundance	1530	873	2.8e-05	9.65e-05
Alistipes_putredinis	diagnosis	CD	diagnosisCD	-0.651	0.15	1.4e-05	5.68e-05	prevalence	1530	873	2.8e-05	9.65e-05
Waltera_intestinalis	diagnosis	UC	diagnosisUC	-0.178	0.344	0.467	0.738	abundance	1530	524	2.93e-05	0.000101
Waltera_intestinalis	diagnosis	UC	diagnosisUC	-0.638	0.147	1.46e-05	5.91e-05	prevalence	1530	524	2.93e-05	0.000101
Phascolarctobacterium_faecium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.902	0.589	0.246	0.454	abundance	1530	503	3.05e-05	0.000104
Phascolarctobacterium_faecium	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.22	0.281	1.52e-05	6.13e-05	prevalence	1530	503	3.05e-05	0.000104
Bacteroides_fragilis	diagnosis	UC	diagnosisUC	1.42	0.309	1.55e-05	0.000192	abundance	1530	787	3.11e-05	0.000106
Bacteroides_fragilis	diagnosis	UC	diagnosisUC	0.334	0.144	0.0207	0.0402	prevalence	1530	787	3.11e-05	0.000106
GGB9713_SGB15249	diagnosis	CD	diagnosisCD	-0.495	0.348	0.221	0.424	abundance	1530	329	3.13e-05	0.000106
Ruminococcus_bromii	diagnosis	CD	diagnosisCD	-0.716	0.271	0.0171	0.0575	abundance	1530	429	3.13e-05	0.000106
GGB9713_SGB15249	diagnosis	CD	diagnosisCD	-0.649	0.15	1.56e-05	6.24e-05	prevalence	1530	329	3.13e-05	0.000106
Ruminococcus_bromii	diagnosis	CD	diagnosisCD	-0.609	0.141	1.56e-05	6.24e-05	prevalence	1530	429	3.13e-05	0.000106
Phascolarctobacterium_faecium	reads	reads	reads	-0.195	0.11	1	1	abundance	1530	503	3.21e-05	0.000108
Phascolarctobacterium_faecium	reads	reads	reads	0.26	0.0602	1.61e-05	6.36e-05	prevalence	1530	503	3.21e-05	0.000108
Prevotella_stercorea	age	age	age	-1.38	0.333	3.26e-05	0.00012	prevalence	1530	40	3.26e-05	0.00011
Prevotella_copri_clade_B	diagnosis	UC	diagnosisUC	-7.4	1.48	1.65e-05	2e-04	abundance	1530	40	3.3e-05	0.000111
Prevotella_copri_clade_B	diagnosis	UC	diagnosisUC	-1.37	0.515	0.00762	0.0167	prevalence	1530	40	3.3e-05	0.000111
Veillonella_parvula	reads	reads	reads	-0.964	0.143	1.67e-05	2e-04	abundance	1530	547	3.34e-05	0.000112
Veillonella_parvula	reads	reads	reads	0.0796	0.0561	0.156	0.23	prevalence	1530	547	3.34e-05	0.000112
Ruminococcus_bicirculans	reads	reads	reads	-0.353	0.108	1	1	abundance	1530	678	3.68e-05	0.000123
Ruminococcus_bicirculans	reads	reads	reads	0.24	0.0561	1.84e-05	7.25e-05	prevalence	1530	678	3.68e-05	0.000123
Eisenbergiella_massiliensis	diagnosis	CD	diagnosisCD	0.5	0.404	0.16	0.331	abundance	1530	417	3.8e-05	0.000126
Eisenbergiella_massiliensis	diagnosis	CD	diagnosisCD	0.653	0.153	1.9e-05	7.47e-05	prevalence	1530	417	3.8e-05	0.000126
Bacteroides_finegoldii	age	age	age	0.307	0.188	0.0928	0.218	abundance	1530	333	4.02e-05	0.000133
Coprococcus_comes	reads	reads	reads	-0.522	0.0812	1	1	abundance	1530	759	4.02e-05	0.000133
Bacteroides_finegoldii	age	age	age	0.261	0.0613	2.01e-05	7.85e-05	prevalence	1530	333	4.02e-05	0.000133
Coprococcus_comes	reads	reads	reads	0.242	0.0568	2.01e-05	7.85e-05	prevalence	1530	759	4.02e-05	0.000133
Ruminococcus_bromii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.498	0.816	0.381	0.627	abundance	1530	429	4.05e-05	0.000133
Ruminococcus_bromii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.53	0.359	2.02e-05	7.87e-05	prevalence	1530	429	4.05e-05	0.000133
Gemmiger_formicilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.57	0.649	2.04e-05	0.000236	abundance	1530	472	4.08e-05	0.000134
Gemmiger_formicilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.01	0.284	0.000387	0.0011	prevalence	1530	472	4.08e-05	0.000134
Alistipes_shahii	reads	reads	reads	0.0204	0.0846	2.14e-05	0.000243	abundance	1530	673	4.27e-05	0.00014
Alistipes_shahii	reads	reads	reads	0.218	0.0574	0.000149	0.000474	prevalence	1530	673	4.27e-05	0.00014
Acidaminococcus_intestini	diagnosis	CD	diagnosisCD	-0.0704	0.524	1	1	abundance	1530	173	4.47e-05	0.000146
Acidaminococcus_intestini	diagnosis	CD	diagnosisCD	0.931	0.219	2.23e-05	8.62e-05	prevalence	1530	173	4.47e-05	0.000146
Dorea_longicatena	reads	reads	reads	-0.435	0.0715	1	1	abundance	1530	1020	4.82e-05	0.000156
Lacrimispora_amygdalina	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.328	0.655	0.265	0.476	abundance	1530	865	4.81e-05	0.000156
Dorea_longicatena	reads	reads	reads	0.255	0.0603	2.41e-05	9.23e-05	prevalence	1530	1020	4.82e-05	0.000156
Lacrimispora_amygdalina	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.58	0.374	2.41e-05	9.23e-05	prevalence	1530	865	4.81e-05	0.000156
Ruminococcus_sp_BSD2780120874_150323_B10	diagnosis	UC	diagnosisUC	-1.83	0.451	4.8e-05	0.000171	prevalence	1530	90	4.8e-05	0.000156
Collinsella_aerofaciens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.22	1.22	0.0315	0.0924	abundance	1530	698	4.88e-05	0.000157
Collinsella_aerofaciens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.24	0.531	2.44e-05	9.31e-05	prevalence	1530	698	4.88e-05	0.000157
GGB9713_SGB15249	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.62	1.36	0.0796	0.193	abundance	1530	329	4.96e-05	0.000159
GGB9713_SGB15249	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.15	0.509	2.48e-05	9.43e-05	prevalence	1530	329	4.96e-05	0.000159
Clostridium_sp_AM49_4BH	age	age	age	0.188	0.13	1	1	abundance	1530	344	5.05e-05	0.000162
Clostridium_sp_AM49_4BH	age	age	age	0.27	0.064	2.53e-05	9.57e-05	prevalence	1530	344	5.05e-05	0.000162
Clostridium_symbiosum	diagnosis	CD	diagnosisCD	-0.541	0.338	0.164	0.339	abundance	1530	539	5.23e-05	0.000167
Clostridium_symbiosum	diagnosis	CD	diagnosisCD	0.639	0.152	2.62e-05	9.87e-05	prevalence	1530	539	5.23e-05	0.000167
Roseburia_inulinivorans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.00757	0.466	1	1	abundance	1530	951	5.57e-05	0.000177
Roseburia_inulinivorans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.96	0.229	2.79e-05	0.000105	prevalence	1530	951	5.57e-05	0.000177
Ruminococcus_bicirculans	diagnosis	UC	diagnosisUC	-0.238	0.245	0.205	0.398	abundance	1530	678	5.62e-05	0.000178
Ruminococcus_bicirculans	diagnosis	UC	diagnosisUC	-0.614	0.147	2.81e-05	0.000105	prevalence	1530	678	5.62e-05	0.000178
Veillonella_rogosae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.31	0.596	0.011	0.0412	abundance	1530	207	5.86e-05	0.000185
Veillonella_rogosae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.09	0.261	2.93e-05	0.000109	prevalence	1530	207	5.86e-05	0.000185
Clostridium_fessum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.768	0.882	0.679	1	abundance	1530	926	5.96e-05	0.000188
Clostridium_fessum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.91	0.458	2.98e-05	0.000111	prevalence	1530	926	5.96e-05	0.000188
Prevotella_copri_clade_E	age	age	age	-1.32	0.329	6.03e-05	0.000208	prevalence	1530	38	6.03e-05	0.00019
GGB9708_SGB15234	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.0147	1.66	1	1	abundance	1530	282	6.07e-05	0.00019
GGB9708_SGB15234	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.4	0.574	3.04e-05	0.000113	prevalence	1530	282	6.07e-05	0.00019
Roseburia_hominis	antibiotics	Yes	antibioticsYes	0.249	0.383	0.401	0.654	abundance	1530	876	6.26e-05	0.000196
Roseburia_hominis	antibiotics	Yes	antibioticsYes	-0.799	0.192	3.13e-05	0.000116	prevalence	1530	876	6.26e-05	0.000196
Bacteroides_finegoldii	reads	reads	reads	-1.06	0.188	0.00018	0.00144	abundance	1530	333	6.32e-05	0.000197
Bacteroides_finegoldii	reads	reads	reads	0.274	0.0659	3.16e-05	0.000116	prevalence	1530	333	6.32e-05	0.000197
GGB3746_SGB5089	age	age	age	-0.446	0.104	3.32e-05	0.000352	abundance	1530	651	6.64e-05	0.000206
GGB3746_SGB5089	age	age	age	0.17	0.0549	0.00199	0.00495	prevalence	1530	651	6.64e-05	0.000206
Firmicutes_bacterium_AF16_15	antibiotics	Yes	antibioticsYes	-0.206	0.393	1	1	abundance	1530	827	6.82e-05	0.000211
Firmicutes_bacterium_AF16_15	antibiotics	Yes	antibioticsYes	-0.865	0.209	3.41e-05	0.000125	prevalence	1530	827	6.82e-05	0.000211
Clostridium_sp_AF20_17LB	diagnosis	CD	diagnosisCD	1.04	0.266	3.47e-05	0.000364	abundance	1530	654	6.95e-05	0.000215
Clostridium_sp_AF20_17LB	diagnosis	CD	diagnosisCD	0.229	0.135	0.0905	0.143	prevalence	1530	654	6.95e-05	0.000215
GGB1543_SGB2126	diagnosis	UC	diagnosisUC	-7.55	1.61	3.64e-05	0.000377	abundance	1530	42	7.29e-05	0.000225
GGB1543_SGB2126	diagnosis	UC	diagnosisUC	-0.784	0.4	0.05	0.0874	prevalence	1530	42	7.29e-05	0.000225
Dysgonomonas_mossii	diagnosis	CD	diagnosisCD	-3.59	0.908	7.64e-05	0.000258	prevalence	1530	31	7.64e-05	0.000235
GGB3267_SGB4317	diagnosis	CD	diagnosisCD	-2.71	1	0.0113	0.042	abundance	1530	54	7.95e-05	0.000244
GGB3267_SGB4317	diagnosis	CD	diagnosisCD	-1.86	0.453	3.98e-05	0.000145	prevalence	1530	54	7.95e-05	0.000244
Barnesiella_intestinihominis	age	age	age	-0.307	0.119	0.0134	0.0482	abundance	1530	431	8.11e-05	0.000248
Barnesiella_intestinihominis	age	age	age	0.236	0.0574	4.05e-05	0.000147	prevalence	1530	431	8.11e-05	0.000248
Enterocloster_clostridioformis	reads	reads	reads	-0.725	0.156	0.0147	0.052	abundance	1530	312	8.36e-05	0.000255
Enterocloster_clostridioformis	reads	reads	reads	0.271	0.0662	4.18e-05	0.000151	prevalence	1530	312	8.36e-05	0.000255
Barnesiella_intestinihominis	diagnosis	CD	diagnosisCD	-0.381	0.29	0.282	0.502	abundance	1530	431	8.53e-05	0.000259
Barnesiella_intestinihominis	diagnosis	CD	diagnosisCD	-0.578	0.141	4.26e-05	0.000153	prevalence	1530	431	8.53e-05	0.000259
Lacrimispora_celerecrescens	diagnosis	CD	diagnosisCD	0.732	0.195	4.42e-05	0.000447	abundance	1530	756	8.85e-05	0.000267
Roseburia_faecis	diagnosis	UC	diagnosisUC	0.685	0.253	0.0159	0.0546	abundance	1530	922	8.85e-05	0.000267
Lacrimispora_celerecrescens	diagnosis	CD	diagnosisCD	-0.403	0.135	0.00286	0.00691	prevalence	1530	756	8.85e-05	0.000267
Roseburia_faecis	diagnosis	UC	diagnosisUC	-0.619	0.152	4.42e-05	0.000159	prevalence	1530	922	8.85e-05	0.000267
Roseburia_faecis	reads	reads	reads	-0.336	0.0959	1	1	abundance	1530	922	8.94e-05	0.000269
Roseburia_faecis	reads	reads	reads	0.234	0.0574	4.47e-05	0.00016	prevalence	1530	922	8.94e-05	0.000269
Prevotella_sp_885	diagnosis	UC	diagnosisUC	2.94	2.85	0.318	0.555	abundance	1530	69	9.67e-05	0.00029
Prevotella_sp_885	diagnosis	UC	diagnosisUC	2.25	0.554	4.84e-05	0.000172	prevalence	1530	69	9.67e-05	0.00029
Tyzzerella_nexilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.34	0.794	0.241	0.448	abundance	1530	188	9.87e-05	0.000296
Tyzzerella_nexilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.5	0.369	4.94e-05	0.000174	prevalence	1530	188	9.87e-05	0.000296
Phocaeicola_sartorii	diagnosis	CD	diagnosisCD	1.31	0.336	5.04e-05	0.000504	abundance	1530	424	0.000101	0.000301
Phocaeicola_sartorii	diagnosis	CD	diagnosisCD	0.109	0.157	0.486	0.584	prevalence	1530	424	0.000101	0.000301
GGB3175_SGB4191	diagnosis	CD	diagnosisCD	-1.38	0.521	0.0131	0.0476	abundance	1530	154	0.000104	0.000309
GGB3175_SGB4191	diagnosis	CD	diagnosisCD	-0.778	0.192	5.18e-05	0.000183	prevalence	1530	154	0.000104	0.000309
Proteus_mirabilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.355	1.32	0.566	0.866	abundance	1530	100	0.000107	0.000316
Proteus_mirabilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.87	0.464	5.33e-05	0.000187	prevalence	1530	100	0.000107	0.000316
Enterocloster_clostridioformis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.74	0.483	6.33e-05	0.000599	abundance	1530	312	0.000108	0.000318
Enterocloster_clostridioformis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.894	0.221	5.38e-05	0.000188	prevalence	1530	312	0.000108	0.000318
Clostridiales_bacterium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.431	0.713	1	1	abundance	1530	985	0.000113	0.000334
Clostridiales_bacterium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.53	0.379	5.66e-05	0.000197	prevalence	1530	985	0.000113	0.000334
GGB3746_SGB5089	diagnosis	CD	diagnosisCD	-0.309	0.248	1	1	abundance	1530	651	0.000115	0.00034
GGB3746_SGB5089	diagnosis	CD	diagnosisCD	-0.547	0.136	5.77e-05	2e-04	prevalence	1530	651	0.000115	0.00034
GGB3746_SGB5089	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.867	0.615	0.0781	0.191	abundance	1530	651	0.000116	0.000341
GGB3746_SGB5089	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.09	0.271	5.8e-05	0.000201	prevalence	1530	651	0.000116	0.000341
Haemophilus_parainfluenzae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.44	0.411	6.12e-05	0.000598	abundance	1530	674	0.000122	0.000358
Haemophilus_parainfluenzae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.442	0.214	0.039	0.07	prevalence	1530	674	0.000122	0.000358
Prevotella_sp_885	diagnosis	CD	diagnosisCD	4.46	2.65	0.0926	0.218	abundance	1530	69	0.000125	0.000366
Prevotella_sp_885	diagnosis	CD	diagnosisCD	2.24	0.559	6.27e-05	0.000216	prevalence	1530	69	0.000125	0.000366
Clostridium_leptum	age	age	age	-0.403	0.0975	6.35e-05	0.000599	abundance	1530	652	0.000127	0.00037
Clostridium_leptum	age	age	age	0.0906	0.0552	0.101	0.158	prevalence	1530	652	0.000127	0.00037
Roseburia_intestinalis	age	age	age	-0.446	0.108	6.39e-05	0.000599	abundance	1530	842	0.000128	0.000371
Roseburia_intestinalis	age	age	age	0.0956	0.0541	0.0774	0.125	prevalence	1530	842	0.000128	0.000371
Bacteroides_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-4.57	1.11	0.000102	0.000874	abundance	1530	434	0.000132	0.000381
Bacteroides_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.29	0.323	6.59e-05	0.000226	prevalence	1530	434	0.000132	0.000381
Bacteroides_salyersiae	antibiotics	Yes	antibioticsYes	1.51	0.577	0.00683	0.0283	abundance	1530	150	0.000138	0.000399
Bacteroides_salyersiae	antibiotics	Yes	antibioticsYes	0.981	0.247	6.9e-05	0.000235	prevalence	1530	150	0.000138	0.000399
Coprococcus_eutactus	diagnosis	UC	diagnosisUC	2.02	0.477	6.93e-05	0.000643	abundance	1530	177	0.000139	0.000399
Coprococcus_eutactus	diagnosis	UC	diagnosisUC	-0.711	0.202	0.000428	0.00121	prevalence	1530	177	0.000139	0.000399
Phascolarctobacterium_faecium	antibiotics	Yes	antibioticsYes	0.329	0.346	0.246	0.454	abundance	1530	503	0.000143	0.000412
Phascolarctobacterium_faecium	antibiotics	Yes	antibioticsYes	0.763	0.192	7.17e-05	0.000244	prevalence	1530	503	0.000143	0.000412
Bacteroides_faecis	age	age	age	-0.704	0.173	7.31e-05	0.000665	abundance	1530	434	0.000146	0.000419
Bacteroides_faecis	age	age	age	0.00738	0.06	0.902	0.931	prevalence	1530	434	0.000146	0.000419
Faecalibacterium_SGB15315	antibiotics	Yes	antibioticsYes	-1.88	0.588	0.00221	0.0113	abundance	1530	619	0.000158	0.000453
Faecalibacterium_SGB15315	antibiotics	Yes	antibioticsYes	-0.909	0.23	7.92e-05	0.000267	prevalence	1530	619	0.000158	0.000453
GGB1549_SGB2133	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-6.22	1.36	7.99e-05	0.000712	abundance	1530	46	0.00016	0.000455
GGB1549_SGB2133	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.951	0.742	0.2	0.285	prevalence	1530	46	0.00016	0.000455
Dorea_longicatena	age	age	age	-0.277	0.0672	8.08e-05	0.000713	abundance	1530	1020	0.000162	0.000459
Dorea_longicatena	age	age	age	0.00183	0.0582	0.975	0.98	prevalence	1530	1020	0.000162	0.000459
Candidatus_Cibionibacter_quicibialis	diagnosis	UC	diagnosisUC	0.256	0.223	1	1	abundance	1530	933	0.000173	0.00049
Phocaeicola_plebeius	age	age	age	-0.205	0.258	1	1	abundance	1530	127	0.000173	0.00049
Candidatus_Cibionibacter_quicibialis	diagnosis	UC	diagnosisUC	-0.599	0.153	8.66e-05	0.00029	prevalence	1530	933	0.000173	0.00049
Phocaeicola_plebeius	age	age	age	0.335	0.0854	8.67e-05	0.00029	prevalence	1530	127	0.000173	0.00049
Anaerostipes_hadrus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.692	0.536	0.0412	0.114	abundance	1530	1130	0.000175	0.000492
Anaerostipes_hadrus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.35	0.345	8.73e-05	0.000291	prevalence	1530	1130	0.000175	0.000492
Parabacteroides_merdae	reads	reads	reads	-0.0214	0.0816	9.23e-05	0.000806	abundance	1530	826	0.000185	0.000519
Parabacteroides_merdae	reads	reads	reads	0.184	0.0562	0.00109	0.00287	prevalence	1530	826	0.000185	0.000519
GGB3746_SGB5089	diagnosis	UC	diagnosisUC	0.49	0.266	0.116	0.26	abundance	1530	651	0.000189	0.00053
GGB3746_SGB5089	diagnosis	UC	diagnosisUC	-0.574	0.147	9.46e-05	0.000312	prevalence	1530	651	0.000189	0.00053
Clostridiaceae_bacterium	diagnosis	CD	diagnosisCD	0.362	0.16	0.00712	0.0291	abundance	1530	1110	0.00019	0.000531
Clostridiaceae_bacterium	diagnosis	CD	diagnosisCD	-0.704	0.18	9.49e-05	0.000312	prevalence	1530	1110	0.00019	0.000531
Veillonella_dispar	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.86	0.53	9.54e-05	0.000826	abundance	1530	526	0.000191	0.000532
Veillonella_dispar	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.453	0.224	0.0432	0.0764	prevalence	1530	526	0.000191	0.000532
Parabacteroides_distasonis	diagnosis	CD	diagnosisCD	0.506	0.148	0.000107	0.000903	abundance	1530	1140	0.000215	0.000597
Parabacteroides_distasonis	diagnosis	CD	diagnosisCD	0.0153	0.161	0.924	0.948	prevalence	1530	1140	0.000215	0.000597
Roseburia_faecis	antibiotics	Yes	antibioticsYes	-0.943	0.359	0.0156	0.0543	abundance	1530	922	0.000231	0.000642
Roseburia_faecis	antibiotics	Yes	antibioticsYes	-0.706	0.183	0.000116	0.000375	prevalence	1530	922	0.000231	0.000642
Rikenellaceae_bacterium	diagnosis	CD	diagnosisCD	-1.15	0.314	0.000234	0.000715	prevalence	1530	67	0.000234	0.000647
Faecalibacterium_prausnitzii	reads	reads	reads	-0.232	0.0511	1	1	abundance	1530	1370	0.000238	0.000658
Faecalibacterium_prausnitzii	reads	reads	reads	0.436	0.113	0.000119	0.000385	prevalence	1530	1370	0.000238	0.000658
Enterocloster_clostridioformis	diagnosis	UC	diagnosisUC	-1.96	0.522	0.000123	0.00102	abundance	1530	312	0.000245	0.000675
Enterocloster_clostridioformis	diagnosis	UC	diagnosisUC	-0.0877	0.198	0.658	0.737	prevalence	1530	312	0.000245	0.000675
GGB16040_SGB9347	diagnosis	UC	diagnosisUC	1.03	0.717	0.184	0.373	abundance	1530	114	0.00025	0.000685
Phocaeicola_massiliensis	diagnosis	CD	diagnosisCD	-0.946	0.398	0.0282	0.085	abundance	1530	396	0.00025	0.000685
GGB16040_SGB9347	diagnosis	UC	diagnosisUC	1.08	0.282	0.000125	0.000402	prevalence	1530	114	0.00025	0.000685
Phocaeicola_massiliensis	diagnosis	CD	diagnosisCD	-0.582	0.152	0.000125	0.000402	prevalence	1530	396	0.00025	0.000685
Phocaeicola_massiliensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-4.06	0.997	0.000138	0.00114	abundance	1530	396	0.000277	0.000756
Butyrivibrio_crossotus	diagnosis	CD	diagnosisCD	-2.25	0.62	0.000278	0.000826	prevalence	1530	43	0.000278	0.000756
Phocaeicola_massiliensis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.03	0.346	0.00293	0.00704	prevalence	1530	396	0.000277	0.000756
Ruminococcus_torques	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.367	0.338	1	1	abundance	1530	1090	0.000292	0.000793
Ruminococcus_torques	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.809	0.213	0.000146	0.000467	prevalence	1530	1090	0.000292	0.000793
Clostridium_symbiosum	reads	reads	reads	-0.73	0.117	0.000996	0.00586	abundance	1530	539	0.000306	0.000828
Clostridium_symbiosum	reads	reads	reads	0.215	0.0568	0.000153	0.000487	prevalence	1530	539	0.000306	0.000828
Prevotella_stercorea	diagnosis	UC	diagnosisUC	2.75	0.761	0.000306	0.000901	prevalence	1530	40	0.000306	0.000828
Sutterella_wadsworthensis	diagnosis	UC	diagnosisUC	-0.504	0.228	0.0117	0.0428	abundance	1530	536	0.000308	0.000831
Sutterella_wadsworthensis	diagnosis	UC	diagnosisUC	-0.574	0.152	0.000154	0.000488	prevalence	1530	536	0.000308	0.000831
Blautia_wexlerae	diagnosis	CD	diagnosisCD	0.555	0.164	0.000155	0.00127	abundance	1530	1300	0.000309	0.000832
Blautia_wexlerae	diagnosis	CD	diagnosisCD	-0.378	0.229	0.0994	0.156	prevalence	1530	1300	0.000309	0.000832
Clostridium_sp_AF36_4	antibiotics	Yes	antibioticsYes	-1.05	0.421	0.0211	0.0682	abundance	1530	568	0.00033	0.000884
Clostridium_sp_AF36_4	antibiotics	Yes	antibioticsYes	-0.857	0.227	0.000165	0.00052	prevalence	1530	568	0.00033	0.000884
Dysosmobacter_sp_BX15	reads	reads	reads	-0.0829	0.0907	1	1	abundance	1530	621	0.000348	0.00093
Dysosmobacter_sp_BX15	reads	reads	reads	0.214	0.0569	0.000174	0.000547	prevalence	1530	621	0.000348	0.00093
Eisenbergiella_massiliensis	age	age	age	-0.645	0.168	0.000176	0.00141	abundance	1530	417	0.000352	0.00094
Eisenbergiella_massiliensis	age	age	age	0.069	0.0591	0.243	0.333	prevalence	1530	417	0.000352	0.00094
Prevotella_copri_clade_B	diagnosis	CD	diagnosisCD	-5.63	1.32	0.000185	0.00145	abundance	1530	40	0.00037	0.000985
Prevotella_copri_clade_B	diagnosis	CD	diagnosisCD	-0.342	0.35	0.329	0.427	prevalence	1530	40	0.00037	0.000985
Bacteroides_eggerthii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-4.79	3.31	0.168	0.346	abundance	1530	409	0.000375	0.000995
Bacteroides_eggerthii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.55	0.683	0.000188	0.000588	prevalence	1530	409	0.000375	0.000995
Prevotella_copri_clade_E	diagnosis	UC	diagnosisUC	2.71	0.762	0.000376	0.00107	prevalence	1530	38	0.000376	0.000995
Hungatella_hathewayi	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.75	0.524	0.000191	0.00148	abundance	1530	451	0.000382	0.00101
Hungatella_hathewayi	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.362	0.216	0.0941	0.149	prevalence	1530	451	0.000382	0.00101
Collinsella_aerofaciens	reads	reads	reads	-0.459	0.0919	1	1	abundance	1530	698	0.000384	0.00101
Collinsella_aerofaciens	reads	reads	reads	0.207	0.0554	0.000192	0.000601	prevalence	1530	698	0.000384	0.00101
Paraprevotella_clara	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-6.6	1.67	0.000193	0.00149	abundance	1530	178	0.000386	0.00102
Paraprevotella_clara	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.54	0.577	0.00765	0.0167	prevalence	1530	178	0.000386	0.00102
Lachnospira_pectinoschiza	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.18	0.686	0.0423	0.116	abundance	1530	500	0.000389	0.00102
Lachnospira_pectinoschiza	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.12	0.3	0.000195	0.000607	prevalence	1530	500	0.000389	0.00102
Acidaminococcus_intestini	antibiotics	Yes	antibioticsYes	-1.35	0.488	0.00945	0.0365	abundance	1530	173	0.00041	0.00107
Acidaminococcus_intestini	antibiotics	Yes	antibioticsYes	0.836	0.225	0.000205	0.000637	prevalence	1530	173	0.00041	0.00107
Blautia_obeum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.18	0.681	0.253	0.463	abundance	1530	899	0.00042	0.0011
Blautia_obeum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.31	0.353	0.00021	0.000651	prevalence	1530	899	0.00042	0.0011
Alistipes_putredinis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.719	1.21	0.353	0.592	abundance	1530	873	0.000424	0.0011
Alistipes_putredinis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.97	0.532	0.000212	0.000655	prevalence	1530	873	0.000424	0.0011
Dysosmobacter_sp_BX15	diagnosis	CD	diagnosisCD	-0.0537	0.194	1	1	abundance	1530	621	0.000432	0.00112
Dysosmobacter_sp_BX15	diagnosis	CD	diagnosisCD	-0.495	0.134	0.000216	0.000666	prevalence	1530	621	0.000432	0.00112
Phocaeicola_dorei	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.0661	0.998	0.776	1	abundance	1530	769	0.000448	0.00116
Phocaeicola_dorei	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.879	0.238	0.000224	0.000689	prevalence	1530	769	0.000448	0.00116
Fusicatenibacter_saccharivorans	age	age	age	-0.106	0.0685	1	1	abundance	1530	1120	0.000457	0.00118
Fusicatenibacter_saccharivorans	age	age	age	0.261	0.0709	0.000228	7e-04	prevalence	1530	1120	0.000457	0.00118
GGB9480_SGB14874	age	age	age	-0.448	0.117	0.000231	0.00172	abundance	1530	332	0.000461	0.00119
GGB9480_SGB14874	age	age	age	0.222	0.0618	0.000333	0.000972	prevalence	1530	332	0.000461	0.00119
Parasutterella_excrementihominis	reads	reads	reads	-0.378	0.102	1	1	abundance	1530	699	0.000474	0.00122
Veillonella_dispar	diagnosis	CD	diagnosisCD	-1.15	0.342	0.00171	0.00919	abundance	1530	526	0.000475	0.00122
Parasutterella_excrementihominis	reads	reads	reads	0.205	0.0559	0.000237	0.000722	prevalence	1530	699	0.000474	0.00122
Veillonella_dispar	diagnosis	CD	diagnosisCD	-0.525	0.143	0.000238	0.000722	prevalence	1530	526	0.000475	0.00122
Anaerostipes_hadrus	reads	reads	reads	-0.481	0.0709	1	1	abundance	1530	1130	0.000486	0.00124
Anaerostipes_hadrus	reads	reads	reads	0.245	0.0668	0.000243	0.000735	prevalence	1530	1130	0.000486	0.00124
Ruthenibacterium_lactatiformans	age	age	age	-0.00639	0.0959	1	1	abundance	1530	797	0.000494	0.00126
Ruthenibacterium_lactatiformans	age	age	age	0.201	0.0548	0.000247	0.000746	prevalence	1530	797	0.000494	0.00126
Clostridium_sp_AT4	age	age	age	0.407	0.113	0.000251	0.00184	abundance	1530	528	0.000502	0.00128
Clostridium_sp_AT4	age	age	age	-0.0376	0.0577	0.514	0.612	prevalence	1530	528	0.000502	0.00128
Bifidobacterium_adolescentis	age	age	age	0.0641	0.151	1	1	abundance	1530	427	0.000508	0.00129
Bifidobacterium_adolescentis	age	age	age	-0.227	0.062	0.000254	0.000766	prevalence	1530	427	0.000508	0.00129
GGB1266_SGB1699	diagnosis	UC	diagnosisUC	-1.47	0.932	0.103	0.237	abundance	1530	84	0.000524	0.00133
GGB1266_SGB1699	diagnosis	UC	diagnosisUC	1.17	0.321	0.000262	0.000786	prevalence	1530	84	0.000524	0.00133
GGB3278_SGB4328	diagnosis	UC	diagnosisUC	-0.989	0.501	0.0356	0.103	abundance	1530	179	0.000545	0.00138
GGB3278_SGB4328	diagnosis	UC	diagnosisUC	-0.749	0.206	0.000272	0.000816	prevalence	1530	179	0.000545	0.00138
Bacteroides_fragilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	2.69	0.625	0.000277	0.002	abundance	1530	787	0.000554	0.00139
Clostridiaceae_bacterium_Marseille_Q4149	diagnosis	CD	diagnosisCD	0.472	0.563	0.338	0.58	abundance	1530	181	0.000553	0.00139
Bacteroides_fragilis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.498	0.336	0.139	0.208	prevalence	1530	787	0.000554	0.00139
Clostridiaceae_bacterium_Marseille_Q4149	diagnosis	CD	diagnosisCD	-0.751	0.207	0.000277	0.000826	prevalence	1530	181	0.000553	0.00139
Bacteroides_ovatus	diagnosis	CD	diagnosisCD	0.623	0.19	0.000281	0.002	abundance	1530	1180	0.000562	0.00141
Bacteroides_ovatus	diagnosis	CD	diagnosisCD	0.182	0.165	0.268	0.36	prevalence	1530	1180	0.000562	0.00141
Lacrimispora_amygdalina	diagnosis	CD	diagnosisCD	0.591	0.181	0.000283	0.002	abundance	1530	865	0.000565	0.00142
Lacrimispora_amygdalina	diagnosis	CD	diagnosisCD	-0.51	0.143	0.000363	0.00105	prevalence	1530	865	0.000565	0.00142
Haemophilus_parainfluenzae	antibiotics	Yes	antibioticsYes	0.79	0.434	0.0473	0.128	abundance	1530	674	0.00057	0.00142
Haemophilus_parainfluenzae	antibiotics	Yes	antibioticsYes	-0.714	0.197	0.000285	0.000846	prevalence	1530	674	0.00057	0.00142
Clostridium_sp_AF34_10BH	age	age	age	0.299	0.0851	0.000292	0.00205	abundance	1530	960	0.000584	0.00146
Clostridium_sp_AF34_10BH	age	age	age	0.118	0.0614	0.0539	0.0934	prevalence	1530	960	0.000584	0.00146
Faecalibacterium_prausnitzii	antibiotics	Yes	antibioticsYes	-0.201	0.186	1	1	abundance	1530	1370	0.00059	0.00147
Faecalibacterium_prausnitzii	antibiotics	Yes	antibioticsYes	-1.01	0.279	0.000295	0.000873	prevalence	1530	1370	0.00059	0.00147
Candidatus_Cibionibacter_quicibialis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.888	0.805	0.109	0.249	abundance	1530	933	0.000593	0.00147
Candidatus_Cibionibacter_quicibialis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.37	0.379	0.000297	0.000876	prevalence	1530	933	0.000593	0.00147
Dysgonomonas_mossii	diagnosis	UC	diagnosisUC	-9	3.81	0.0254	0.0798	abundance	1530	31	0.000621	0.00154
Dysgonomonas_mossii	diagnosis	UC	diagnosisUC	-1.85	0.513	0.000311	0.000912	prevalence	1530	31	0.000621	0.00154
Bacteroides_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.77	1.49	0.018	0.0598	abundance	1530	158	0.000642	0.00159
Bacteroides_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.89	0.525	0.000321	0.00094	prevalence	1530	158	0.000642	0.00159
Bacteroides_fragilis	antibiotics	Yes	antibioticsYes	-1.24	0.407	0.0044	0.0196	abundance	1530	787	0.000675	0.00166
Bacteroides_fragilis	antibiotics	Yes	antibioticsYes	-0.655	0.183	0.000337	0.000982	prevalence	1530	787	0.000675	0.00166
Alistipes_onderdonkii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.782	2.8	0.892	1	abundance	1530	831	0.000681	0.00167
Alistipes_onderdonkii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-3.49	0.973	0.000341	0.000989	prevalence	1530	831	0.000681	0.00167
Gemmiger_formicilis	reads	reads	reads	-0.58	0.123	1	1	abundance	1530	472	0.000698	0.00171
Gemmiger_formicilis	reads	reads	reads	0.216	0.0603	0.000349	0.00101	prevalence	1530	472	0.000698	0.00171
Parasutterella_excrementihominis	antibiotics	Yes	antibioticsYes	-0.386	0.336	0.352	0.592	abundance	1530	699	0.000728	0.00178
Parasutterella_excrementihominis	antibiotics	Yes	antibioticsYes	0.672	0.188	0.000364	0.00105	prevalence	1530	699	0.000728	0.00178
Ruminococcus_bicirculans	age	age	age	0.214	0.0963	1	1	abundance	1530	678	0.000733	0.00179
Ruminococcus_bicirculans	age	age	age	0.194	0.0545	0.000366	0.00105	prevalence	1530	678	0.000733	0.00179
Clostridiaceae_bacterium_Marseille_Q4149	age	age	age	0.294	0.207	0.142	0.302	abundance	1530	181	0.000738	0.0018
Clostridiaceae_bacterium_Marseille_Q4149	age	age	age	0.262	0.0736	0.000369	0.00106	prevalence	1530	181	0.000738	0.0018
Bacteroides_intestinalis	antibiotics	Yes	antibioticsYes	2.42	0.686	0.000385	0.00263	abundance	1530	158	0.000771	0.00187
Roseburia_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	1.59	0.507	0.000385	0.00263	abundance	1530	842	0.000771	0.00187
Bacteroides_intestinalis	antibiotics	Yes	antibioticsYes	0.72	0.251	0.00412	0.00956	prevalence	1530	158	0.000771	0.00187
Roseburia_intestinalis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.405	0.214	0.0576	0.0982	prevalence	1530	842	0.000771	0.00187
Enterocloster_clostridioformis	diagnosis	CD	diagnosisCD	0.793	0.429	0.0456	0.124	abundance	1530	312	0.000782	0.00189
Enterocloster_clostridioformis	diagnosis	CD	diagnosisCD	0.609	0.172	0.000391	0.00111	prevalence	1530	312	0.000782	0.00189
Dorea_longicatena	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.417	0.553	0.138	0.297	abundance	1530	1020	0.000795	0.00192
Dorea_longicatena	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.22	0.344	0.000397	0.00113	prevalence	1530	1020	0.000795	0.00192
GGB3278_SGB4328	age	age	age	-0.729	0.199	0.000412	0.00277	abundance	1530	179	0.000824	0.00198
GGB3278_SGB4328	age	age	age	0.02	0.0787	0.8	0.846	prevalence	1530	179	0.000824	0.00198
Alistipes_dispar	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	8.43	2.17	0.000423	0.00282	abundance	1530	83	0.000846	0.00203
Alistipes_dispar	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.168	1.02	0.869	0.904	prevalence	1530	83	0.000846	0.00203
Bifidobacterium_adolescentis	antibiotics	Yes	antibioticsYes	-1.92	0.747	0.014	0.0499	abundance	1530	427	0.000923	0.00221
Bifidobacterium_adolescentis	antibiotics	Yes	antibioticsYes	-0.997	0.285	0.000462	0.0013	prevalence	1530	427	0.000923	0.00221
Dialister_invisus	diagnosis	UC	diagnosisUC	-0.788	0.245	0.000472	0.0031	abundance	1530	726	0.000945	0.00226
Dialister_invisus	diagnosis	UC	diagnosisUC	0.0926	0.147	0.53	0.625	prevalence	1530	726	0.000945	0.00226
Veillonella_parvula	diagnosis	CD	diagnosisCD	0.572	0.343	0.0619	0.16	abundance	1530	547	0.000965	0.0023
Veillonella_parvula	diagnosis	CD	diagnosisCD	-0.488	0.14	0.000483	0.00136	prevalence	1530	547	0.000965	0.0023
Akkermansia_muciniphila	antibiotics	Yes	antibioticsYes	-0.145	0.71	1	1	abundance	1530	407	0.000973	0.00232
Akkermansia_muciniphila	antibiotics	Yes	antibioticsYes	-0.871	0.25	0.000487	0.00137	prevalence	1530	407	0.000973	0.00232
Klebsiella_pneumoniae	antibiotics	Yes	antibioticsYes	2.29	0.657	0.000488	0.00318	abundance	1530	119	0.000976	0.00232
Klebsiella_pneumoniae	antibiotics	Yes	antibioticsYes	0.559	0.264	0.0342	0.0627	prevalence	1530	119	0.000976	0.00232
Bacteroides_finegoldii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.23	1.54	0.192	0.381	abundance	1530	333	0.000983	0.00233
Bacteroides_finegoldii	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.64	0.47	0.000492	0.00137	prevalence	1530	333	0.000983	0.00233
Veillonella_dispar	reads	reads	reads	-0.847	0.144	0.000496	0.00321	abundance	1530	526	0.000991	0.00234
Veillonella_dispar	reads	reads	reads	0.00485	0.0571	0.932	0.952	prevalence	1530	526	0.000991	0.00234
Alistipes_finegoldii	reads	reads	reads	0.0511	0.112	0.000502	0.00323	abundance	1530	639	0.001	0.00237
Alistipes_finegoldii	reads	reads	reads	0.144	0.0567	0.0112	0.0233	prevalence	1530	639	0.001	0.00237
Bacteroides_caecigallinarum	diagnosis	CD	diagnosisCD	6.73	7.47	0.378	0.625	abundance	1530	21	0.00103	0.00242
Bifidobacterium_adolescentis	diagnosis	UC	diagnosisUC	1.2	0.322	0.000515	0.00329	abundance	1530	427	0.00103	0.00242
Bacteroides_caecigallinarum	diagnosis	CD	diagnosisCD	-2.51	0.722	0.000515	0.00144	prevalence	1530	21	0.00103	0.00242
Bifidobacterium_adolescentis	diagnosis	UC	diagnosisUC	-0.242	0.149	0.105	0.162	prevalence	1530	427	0.00103	0.00242
Akkermansia_sp_KLE1798	reads	reads	reads	0.413	0.126	0.00105	0.00275	prevalence	1530	70	0.00105	0.00245
Rikenellaceae_bacterium	reads	reads	reads	0.386	0.118	0.00105	0.00277	prevalence	1530	67	0.00105	0.00246
Bacteroides_xylanisolvens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.527	1.06	0.381	0.627	abundance	1530	959	0.00106	0.00246
Bacteroides_xylanisolvens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.25	0.36	0.000528	0.00147	prevalence	1530	959	0.00106	0.00246
Veillonella_rogosae	antibiotics	Yes	antibioticsYes	2.98	0.867	0.000537	0.0034	abundance	1530	207	0.00107	0.0025
Veillonella_rogosae	antibiotics	Yes	antibioticsYes	-0.965	0.342	0.00474	0.0108	prevalence	1530	207	0.00107	0.0025
Eubacterium_siraeum	diagnosis	CD	diagnosisCD	-1.19	0.322	0.00054	0.0034	abundance	1530	565	0.00108	0.00251
Eubacterium_siraeum	diagnosis	CD	diagnosisCD	-0.456	0.135	0.000761	0.00205	prevalence	1530	565	0.00108	0.00251
Clostridium_sp_AF34_10BH	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.81	0.787	0.075	0.185	abundance	1530	960	0.00112	0.00259
Clostridium_sp_AF34_10BH	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.28	0.371	0.000559	0.00155	prevalence	1530	960	0.00112	0.00259
Bacteroides_xylanisolvens	diagnosis	CD	diagnosisCD	-0.0686	0.284	1	1	abundance	1530	959	0.00117	0.00271
Bacteroides_xylanisolvens	diagnosis	CD	diagnosisCD	0.503	0.146	0.000585	0.00162	prevalence	1530	959	0.00117	0.00271
Bacteroides_fragilis	reads	reads	reads	-0.357	0.108	1	1	abundance	1530	787	0.00118	0.00272
Bacteroides_fragilis	reads	reads	reads	0.187	0.0545	0.00059	0.00163	prevalence	1530	787	0.00118	0.00272
Roseburia_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.582	0.411	0.376	0.623	abundance	1530	922	0.00127	0.00293
Roseburia_faecis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.726	0.212	0.000635	0.00174	prevalence	1530	922	0.00127	0.00293
Lachnospira_eligens	diagnosis	CD	diagnosisCD	0.201	0.214	0.206	0.399	abundance	1530	929	0.00136	0.00313
Lachnospira_eligens	diagnosis	CD	diagnosisCD	-0.48	0.141	0.00068	0.00186	prevalence	1530	929	0.00136	0.00313
Ruminococcus_lactaris	reads	reads	reads	-0.286	0.127	1	1	abundance	1530	379	0.00138	0.00316
Ruminococcus_lactaris	reads	reads	reads	0.215	0.0633	0.000689	0.00188	prevalence	1530	379	0.00138	0.00316
Lacrimispora_celerecrescens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.798	0.631	0.532	0.824	abundance	1530	756	0.0014	0.00321
Lacrimispora_celerecrescens	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.22	0.359	0.000701	0.00191	prevalence	1530	756	0.0014	0.00321
Alistipes_shahii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.794	1.45	0.787	1	abundance	1530	673	0.00143	0.00326
Roseburia_intestinalis	diagnosis	CD	diagnosisCD	-0.169	0.273	1	1	abundance	1530	842	0.00143	0.00326
Alistipes_shahii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.43	0.717	0.000715	0.00194	prevalence	1530	673	0.00143	0.00326
Roseburia_intestinalis	diagnosis	CD	diagnosisCD	-0.457	0.135	0.000715	0.00194	prevalence	1530	842	0.00143	0.00326
Bilophila_wadsworthia	age	age	age	-0.278	0.0789	0.000753	0.00464	abundance	1530	764	0.00151	0.00342
Bilophila_wadsworthia	age	age	age	0.176	0.0562	0.00179	0.00452	prevalence	1530	764	0.00151	0.00342
Dialister_invisus	diagnosis	CD	diagnosisCD	-0.0691	0.216	1	1	abundance	1530	726	0.00152	0.00345
Dialister_invisus	diagnosis	CD	diagnosisCD	0.46	0.137	0.000762	0.00205	prevalence	1530	726	0.00152	0.00345
GGB781_SGB1024	age	age	age	0.598	0.189	0.00152	0.00393	prevalence	1530	18	0.00152	0.00345
Alistipes_communis	antibiotics	Yes	antibioticsYes	-0.0777	0.485	1	1	abundance	1530	407	0.00154	0.00347
Alistipes_communis	antibiotics	Yes	antibioticsYes	-0.824	0.245	0.000768	0.00207	prevalence	1530	407	0.00154	0.00347
Odoribacter_splanchnicus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.435	1.27	1	1	abundance	1530	757	0.00155	0.00349
Odoribacter_splanchnicus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.42	0.719	0.000774	0.00208	prevalence	1530	757	0.00155	0.00349
Bifidobacterium_longum	diagnosis	UC	diagnosisUC	0.00133	0.244	1	1	abundance	1530	843	0.00159	0.00358
Lachnospira_pectinoschiza	antibiotics	Yes	antibioticsYes	-1.57	0.501	0.00291	0.014	abundance	1530	500	0.00159	0.00358
Bifidobacterium_longum	diagnosis	UC	diagnosisUC	0.523	0.156	0.000796	0.00213	prevalence	1530	843	0.00159	0.00358
Lachnospira_pectinoschiza	antibiotics	Yes	antibioticsYes	-0.762	0.227	0.000797	0.00213	prevalence	1530	500	0.00159	0.00358
Bacteroides_caecigallinarum	diagnosis	UC	diagnosisUC	-9.26	2.2	0.000811	0.0049	abundance	1530	21	0.00162	0.00363
Bacteroides_caecigallinarum	diagnosis	UC	diagnosisUC	-1.42	0.571	0.0128	0.0266	prevalence	1530	21	0.00162	0.00363
Alistipes_putredinis	reads	reads	reads	-0.194	0.0819	1	1	abundance	1530	873	0.00173	0.00386
Alistipes_putredinis	reads	reads	reads	0.197	0.0593	0.000865	0.0023	prevalence	1530	873	0.00173	0.00386
Bilophila_wadsworthia	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.812	2.26	0.591	0.899	abundance	1530	764	0.00176	0.00392
Bilophila_wadsworthia	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-3.25	0.977	0.000879	0.00233	prevalence	1530	764	0.00176	0.00392
Phocaeicola_coprocola	antibiotics	Yes	antibioticsYes	-4.66	1.34	0.000899	0.00539	abundance	1530	101	0.0018	0.004
Phocaeicola_coprocola	antibiotics	Yes	antibioticsYes	-0.597	0.402	0.138	0.207	prevalence	1530	101	0.0018	0.004
Phocaeicola_vulgatus	reads	reads	reads	-0.193	0.0985	1	1	abundance	1530	1290	0.00184	0.00408
Phocaeicola_vulgatus	reads	reads	reads	0.267	0.0804	0.00092	0.00244	prevalence	1530	1290	0.00184	0.00408
Bifidobacterium_adolescentis	reads	reads	reads	-0.629	0.14	0.0408	0.113	abundance	1530	427	0.00199	0.00442
Bifidobacterium_adolescentis	reads	reads	reads	0.202	0.0614	0.000997	0.00263	prevalence	1530	427	0.00199	0.00442
Prevotella_copri_clade_A	diagnosis	CD	diagnosisCD	-2.36	0.694	0.00109	0.00635	abundance	1530	289	0.00217	0.0048
Prevotella_copri_clade_A	diagnosis	CD	diagnosisCD	-0.481	0.164	0.00336	0.00797	prevalence	1530	289	0.00217	0.0048
Ruminococcus_bicirculans	antibiotics	Yes	antibioticsYes	-1.06	0.443	0.0259	0.0802	abundance	1530	678	0.00221	0.00487
Ruminococcus_bicirculans	antibiotics	Yes	antibioticsYes	-0.651	0.2	0.0011	0.00289	prevalence	1530	678	0.00221	0.00487
Phocaeicola_coprocola	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-5.44	1.56	0.00114	0.00663	abundance	1530	101	0.00228	0.00503
Phocaeicola_coprocola	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.775	0.474	0.102	0.159	prevalence	1530	101	0.00228	0.00503
Barnesiella_intestinihominis	reads	reads	reads	0.0409	0.132	0.00385	0.0178	abundance	1530	431	0.00237	0.0052
Barnesiella_intestinihominis	reads	reads	reads	0.197	0.0608	0.00118	0.00309	prevalence	1530	431	0.00237	0.0052
Alistipes_finegoldii	age	age	age	-0.349	0.104	0.00122	0.00701	abundance	1530	639	0.00244	0.00536
Alistipes_finegoldii	age	age	age	-0.0693	0.0554	0.211	0.297	prevalence	1530	639	0.00244	0.00536
Ruminococcus_lactaris	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.741	1.22	0.433	0.697	abundance	1530	379	0.00271	0.00593
Ruminococcus_lactaris	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.63	0.508	0.00136	0.00353	prevalence	1530	379	0.00271	0.00593
Acidaminococcus_intestini	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.372	0.853	0.489	0.766	abundance	1530	173	0.00272	0.00595
Acidaminococcus_intestini	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.19	0.372	0.00136	0.00354	prevalence	1530	173	0.00272	0.00595
Candidatus_Cibionibacter_quicibialis	age	age	age	0.261	0.0846	0.00137	0.00775	abundance	1530	933	0.00274	0.00597
Candidatus_Cibionibacter_quicibialis	age	age	age	0.108	0.0573	0.0603	0.101	prevalence	1530	933	0.00274	0.00597
GGB51647_SGB4348	diagnosis	CD	diagnosisCD	0.566	0.61	0.3	0.527	abundance	1530	123	0.0028	0.00608
GGB51647_SGB4348	diagnosis	CD	diagnosisCD	-0.758	0.237	0.0014	0.00363	prevalence	1530	123	0.0028	0.00608
Odoribacter_splanchnicus	diagnosis	CD	diagnosisCD	0.418	0.152	0.00145	0.00813	abundance	1530	757	0.00291	0.00631
Odoribacter_splanchnicus	diagnosis	CD	diagnosisCD	-0.2	0.136	0.142	0.212	prevalence	1530	757	0.00291	0.00631
Dysosmobacter_sp_BX15	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.85	1.02	0.0271	0.0832	abundance	1530	621	0.00311	0.00674
Dysosmobacter_sp_BX15	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.69	0.533	0.00156	0.00401	prevalence	1530	621	0.00311	0.00674
Alistipes_SGB2313	diagnosis	CD	diagnosisCD	-2.83	0.837	0.00157	0.00868	abundance	1530	73	0.00314	0.00679
Alistipes_SGB2313	diagnosis	CD	diagnosisCD	-0.548	0.307	0.0744	0.121	prevalence	1530	73	0.00314	0.00679
Prevotella_marseillensis	antibiotics	Yes	antibioticsYes	1.6	0.543	0.00321	0.00768	prevalence	1530	18	0.00321	0.00693
Bifidobacterium_longum	reads	reads	reads	-0.645	0.0959	0.00161	0.00875	abundance	1530	843	0.00323	0.00694
Bifidobacterium_longum	reads	reads	reads	0.171	0.057	0.00262	0.00635	prevalence	1530	843	0.00323	0.00694
GGB3478_SGB14857	antibiotics	Yes	antibioticsYes	5.02	1.77	0.0182	0.0599	abundance	1530	16	0.00324	0.00696
GGB3478_SGB14857	antibiotics	Yes	antibioticsYes	1.58	0.501	0.00162	0.00417	prevalence	1530	16	0.00324	0.00696
Parasutterella_SGB9260	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.65	1.28	0.0579	0.153	abundance	1530	269	0.00325	0.00697
Parasutterella_SGB9260	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.81	0.574	0.00163	0.00417	prevalence	1530	269	0.00325	0.00697
Clostridium_leptum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.706	0.973	0.756	1	abundance	1530	652	0.00339	0.00726
Clostridium_leptum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.35	0.43	0.0017	0.00433	prevalence	1530	652	0.00339	0.00726
Clostridium_fessum	antibiotics	Yes	antibioticsYes	-0.435	0.283	0.2	0.393	abundance	1530	926	0.00342	0.00729
Clostridium_fessum	antibiotics	Yes	antibioticsYes	-0.62	0.198	0.00171	0.00435	prevalence	1530	926	0.00342	0.00729
Phocaeicola_massiliensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.0915	1.77	0.78	1	abundance	1530	396	0.00347	0.00739
Phocaeicola_massiliensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.88	0.601	0.00173	0.00441	prevalence	1530	396	0.00347	0.00739
Bacteroides_thetaiotaomicron	antibiotics	Yes	antibioticsYes	0.991	0.339	0.00174	0.00935	abundance	1530	1060	0.00349	0.00741
Bacteroides_thetaiotaomicron	antibiotics	Yes	antibioticsYes	-0.0976	0.204	0.632	0.714	prevalence	1530	1060	0.00349	0.00741
Haemophilus_parainfluenzae	diagnosis	CD	diagnosisCD	-0.184	0.263	1	1	abundance	1530	674	0.00351	0.00745
Parasutterella_excrementihominis	diagnosis	UC	diagnosisUC	0.836	0.243	0.00176	0.00935	abundance	1530	699	0.00351	0.00745
Haemophilus_parainfluenzae	diagnosis	CD	diagnosisCD	-0.427	0.137	0.00176	0.00446	prevalence	1530	674	0.00351	0.00745
Parasutterella_excrementihominis	diagnosis	UC	diagnosisUC	0.0636	0.145	0.66	0.738	prevalence	1530	699	0.00351	0.00745
Waltera_intestinalis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.06	2.23	0.767	1	abundance	1530	524	0.00363	0.00767
Waltera_intestinalis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.24	0.719	0.00182	0.00458	prevalence	1530	524	0.00363	0.00767
Alistipes_dispar	diagnosis	UC	diagnosisUC	-1.12	0.739	0.111	0.253	abundance	1530	83	0.00364	0.00767
Alistipes_dispar	diagnosis	UC	diagnosisUC	-1.11	0.356	0.00182	0.00458	prevalence	1530	83	0.00364	0.00767
GGB9480_SGB14874	diagnosis	UC	diagnosisUC	-0.279	0.349	0.314	0.549	abundance	1530	332	0.00374	0.00787
GGB9480_SGB14874	diagnosis	UC	diagnosisUC	-0.557	0.179	0.00187	0.0047	prevalence	1530	332	0.00374	0.00787
Flavonifractor_plautii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.01	0.485	0.211	0.407	abundance	1530	1220	0.00376	0.00789
Flavonifractor_plautii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.14	0.366	0.00188	0.00471	prevalence	1530	1220	0.00376	0.00789
Escherichia_coli	age	age	age	0.361	0.119	0.00191	0.00998	abundance	1530	707	0.00381	0.00799
Escherichia_coli	age	age	age	-0.0974	0.0537	0.0698	0.115	prevalence	1530	707	0.00381	0.00799
Ruminococcus_gnavus	diagnosis	UC	diagnosisUC	-0.495	0.289	0.0498	0.134	abundance	1530	767	0.00387	0.0081
Ruminococcus_gnavus	diagnosis	UC	diagnosisUC	0.455	0.147	0.00194	0.00484	prevalence	1530	767	0.00387	0.0081
Bifidobacterium_adolescentis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.41	1.61	0.261	0.471	abundance	1530	427	0.0039	0.00815
Bifidobacterium_adolescentis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.87	0.603	0.00195	0.00487	prevalence	1530	427	0.0039	0.00815
Akkermansia_muciniphila	reads	reads	reads	-0.481	0.16	1	1	abundance	1530	407	0.00398	0.00831
Akkermansia_muciniphila	reads	reads	reads	0.193	0.0624	0.00199	0.00495	prevalence	1530	407	0.00398	0.00831
Veillonella_rogosae	reads	reads	reads	-0.987	0.207	0.00207	0.0107	abundance	1530	207	0.00413	0.00858
Veillonella_rogosae	reads	reads	reads	0.0304	0.0778	0.696	0.768	prevalence	1530	207	0.00413	0.00858
Proteus_mirabilis	diagnosis	CD	diagnosisCD	-1.64	0.864	0.0722	0.18	abundance	1530	100	0.00414	0.00859
Vescimonas_coprocola	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.45	1.39	0.181	0.369	abundance	1530	599	0.00415	0.00859
Proteus_mirabilis	diagnosis	CD	diagnosisCD	-0.874	0.284	0.00207	0.00513	prevalence	1530	100	0.00414	0.00859
Vescimonas_coprocola	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.85	0.602	0.00208	0.00513	prevalence	1530	599	0.00415	0.00859
Waltera_intestinalis	age	age	age	0.389	0.139	0.00418	0.0189	abundance	1530	524	0.00418	0.00864
Waltera_intestinalis	age	age	age	0.172	0.0559	0.00209	0.00515	prevalence	1530	524	0.00418	0.00864
Bacteroides_faecis	antibiotics	Yes	antibioticsYes	-1.41	0.77	0.0836	0.201	abundance	1530	434	0.00435	0.00898
Bacteroides_faecis	antibiotics	Yes	antibioticsYes	-0.737	0.24	0.00218	0.00535	prevalence	1530	434	0.00435	0.00898
Clostridium_sp_AM49_4BH	antibiotics	Yes	antibioticsYes	-0.118	0.829	1	1	abundance	1530	344	0.00447	0.00921
Clostridium_sp_AM49_4BH	antibiotics	Yes	antibioticsYes	-1.05	0.342	0.00224	0.00549	prevalence	1530	344	0.00447	0.00921
Clostridium_sp_AM22_11AC	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.02	0.796	0.441	0.704	abundance	1530	730	0.00457	0.00939
Clostridium_sp_AM22_11AC	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.16	0.381	0.00229	0.00559	prevalence	1530	730	0.00457	0.00939
Phocaeicola_vulgatus	age	age	age	-0.308	0.0973	0.00233	0.0119	abundance	1530	1290	0.00466	0.00956
Phocaeicola_vulgatus	age	age	age	0.0112	0.0783	0.886	0.92	prevalence	1530	1290	0.00466	0.00956
Prevotella_copri_clade_B	antibiotics	Yes	antibioticsYes	-8.34	2.51	0.0024	0.0121	abundance	1530	40	0.00479	0.00982
Prevotella_copri_clade_B	antibiotics	Yes	antibioticsYes	-1.29	0.889	0.146	0.216	prevalence	1530	40	0.00479	0.00982
Lacrimispora_celerecrescens	antibiotics	Yes	antibioticsYes	0.809	0.29	0.00244	0.0122	abundance	1530	756	0.00488	0.00998
Lacrimispora_celerecrescens	antibiotics	Yes	antibioticsYes	0.05	0.191	0.793	0.842	prevalence	1530	756	0.00488	0.00998
Proteus_mirabilis	age	age	age	0.275	0.551	1	1	abundance	1530	100	0.00494	0.0101
Proteus_mirabilis	age	age	age	-0.382	0.126	0.00247	0.00602	prevalence	1530	100	0.00494	0.0101
Bacteroides_salyersiae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-4.07	1.25	0.0025	0.0123	abundance	1530	150	0.00498	0.0102
Bacteroides_salyersiae	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.5	0.526	0.00434	0.00995	prevalence	1530	150	0.00498	0.0102
Akkermansia_sp_KLE1798	age	age	age	-0.397	0.142	0.0051	0.0115	prevalence	1530	70	0.0051	0.0104
Bacteroides_eggerthii	diagnosis	UC	diagnosisUC	0.278	0.587	1	1	abundance	1530	409	0.00515	0.0105
Bacteroides_eggerthii	diagnosis	UC	diagnosisUC	-0.467	0.155	0.00258	0.00627	prevalence	1530	409	0.00515	0.0105
Bacteroides_ovatus	antibiotics	Yes	antibioticsYes	0.712	0.26	0.00264	0.013	abundance	1530	1180	0.00527	0.0107
Bacteroides_ovatus	antibiotics	Yes	antibioticsYes	0.226	0.226	0.317	0.415	prevalence	1530	1180	0.00527	0.0107
Waltera_intestinalis	reads	reads	reads	-0.629	0.152	0.0597	0.156	abundance	1530	524	0.00558	0.0113
Waltera_intestinalis	reads	reads	reads	0.175	0.0586	0.0028	0.00676	prevalence	1530	524	0.00558	0.0113
Collinsella_SGB14861	age	age	age	-0.297	0.0956	0.00284	0.0139	abundance	1530	593	0.00568	0.0115
GGB9453_SGB14844	diagnosis	UC	diagnosisUC	-1.29	0.45	0.00285	0.0139	abundance	1530	222	0.00569	0.0115
Collinsella_SGB14861	age	age	age	0.0721	0.0552	0.191	0.273	prevalence	1530	593	0.00568	0.0115
GGB9453_SGB14844	diagnosis	UC	diagnosisUC	0.202	0.193	0.296	0.391	prevalence	1530	222	0.00569	0.0115
Phascolarctobacterium_faecium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.504	1.35	0.502	0.785	abundance	1530	503	0.0058	0.0117
Phascolarctobacterium_faecium	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.8	0.606	0.0029	0.00699	prevalence	1530	503	0.0058	0.0117
Ruminococcus_torques	diagnosis	UC	diagnosisUC	0.575	0.197	0.011	0.0412	abundance	1530	1090	0.0059	0.0118
Ruminococcus_torques	diagnosis	UC	diagnosisUC	-0.519	0.175	0.00296	0.00709	prevalence	1530	1090	0.0059	0.0118
Paraprevotella_clara	age	age	age	-0.889	0.293	0.00315	0.0151	abundance	1530	178	0.00629	0.0126
Paraprevotella_clara	age	age	age	-0.187	0.0866	0.031	0.0578	prevalence	1530	178	0.00629	0.0126
Alistipes_communis	diagnosis	CD	diagnosisCD	-0.831	0.257	0.00323	0.0153	abundance	1530	407	0.00645	0.0129
Alistipes_communis	diagnosis	CD	diagnosisCD	0.133	0.143	0.355	0.453	prevalence	1530	407	0.00645	0.0129
Parabacteroides_merdae	diagnosis	UC	diagnosisUC	-0.516	0.199	0.00324	0.0153	abundance	1530	826	0.00648	0.0129
Parabacteroides_merdae	diagnosis	UC	diagnosisUC	0.301	0.146	0.04	0.0715	prevalence	1530	826	0.00648	0.0129
Waltera_intestinalis	antibiotics	Yes	antibioticsYes	0.296	0.624	0.555	0.855	abundance	1530	524	0.0065	0.0129
Waltera_intestinalis	antibiotics	Yes	antibioticsYes	-0.672	0.228	0.00325	0.00776	prevalence	1530	524	0.0065	0.0129
Phocaeicola_coprocola	age	age	age	0.232	0.382	1	1	abundance	1530	101	0.00652	0.013
Phocaeicola_coprocola	age	age	age	0.288	0.098	0.00327	0.00777	prevalence	1530	101	0.00652	0.013
Alistipes_finegoldii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	4.82	2.51	0.0791	0.192	abundance	1530	639	0.00663	0.0131
Alistipes_finegoldii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.86	0.974	0.00332	0.00789	prevalence	1530	639	0.00663	0.0131
Prevotella_marseillensis	diagnosis	UC	diagnosisUC	2.13	0.785	0.00666	0.0147	prevalence	1530	18	0.00666	0.0132
Eisenbergiella_massiliensis	reads	reads	reads	-0.6	0.156	0.0994	0.232	abundance	1530	417	0.00686	0.0135
Eisenbergiella_massiliensis	reads	reads	reads	0.173	0.0591	0.00343	0.00812	prevalence	1530	417	0.00686	0.0135
Phocaeicola_sartorii	antibiotics	Yes	antibioticsYes	-0.117	0.446	1	1	abundance	1530	424	0.00705	0.0139
Ruminococcus_lactaris	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.0151	2.41	0.862	1	abundance	1530	379	0.00706	0.0139
Phocaeicola_sartorii	antibiotics	Yes	antibioticsYes	0.615	0.211	0.00353	0.00832	prevalence	1530	424	0.00705	0.0139
Ruminococcus_lactaris	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.84	0.975	0.00353	0.00832	prevalence	1530	379	0.00706	0.0139
Firmicutes_bacterium_AF16_15	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.16	0.986	0.113	0.256	abundance	1530	827	0.00707	0.0139
Firmicutes_bacterium_AF16_15	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.26	0.433	0.00354	0.00832	prevalence	1530	827	0.00707	0.0139
Bacteroides_finegoldii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-9.3	3.32	0.00375	0.0174	abundance	1530	333	0.00748	0.0147
Bacteroides_finegoldii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.53	0.977	0.00968	0.0207	prevalence	1530	333	0.00748	0.0147
Clostridiaceae_bacterium	antibiotics	Yes	antibioticsYes	-0.0144	0.254	1	1	abundance	1530	1110	0.00763	0.0149
Clostridiaceae_bacterium	antibiotics	Yes	antibioticsYes	-0.568	0.196	0.00382	0.00893	prevalence	1530	1110	0.00763	0.0149
Ruminococcus_torques	antibiotics	Yes	antibioticsYes	0.175	0.248	1	1	abundance	1530	1090	0.00768	0.015
Ruminococcus_torques	antibiotics	Yes	antibioticsYes	0.619	0.214	0.00385	0.00897	prevalence	1530	1090	0.00768	0.015
Dorea_longicatena	diagnosis	CD	diagnosisCD	0.41	0.165	0.00388	0.0178	abundance	1530	1020	0.00775	0.0151
Dorea_longicatena	diagnosis	CD	diagnosisCD	-0.0966	0.149	0.517	0.613	prevalence	1530	1020	0.00775	0.0151
Gemmiger_formicilis	age	age	age	-0.394	0.132	0.00394	0.018	abundance	1530	472	0.00787	0.0153
Gemmiger_formicilis	age	age	age	-0.132	0.0601	0.0286	0.0537	prevalence	1530	472	0.00787	0.0153
Clostridium_sp_AM49_4BH	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.341	1.82	0.759	1	abundance	1530	344	0.00795	0.0154
Clostridium_sp_AM49_4BH	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.97	0.684	0.00398	0.00927	prevalence	1530	344	0.00795	0.0154
GGB3278_SGB4328	antibiotics	Yes	antibioticsYes	0.0294	1.56	1	1	abundance	1530	179	0.00831	0.0161
GGB3278_SGB4328	antibiotics	Yes	antibioticsYes	-1.61	0.564	0.00416	0.00965	prevalence	1530	179	0.00831	0.0161
Proteus_mirabilis	antibiotics	Yes	antibioticsYes	2.78	0.972	0.00417	0.0189	abundance	1530	100	0.00833	0.0161
Proteus_mirabilis	antibiotics	Yes	antibioticsYes	-0.0304	0.342	0.929	0.951	prevalence	1530	100	0.00833	0.0161
Lacrimispora_amygdalina	antibiotics	Yes	antibioticsYes	-0.37	0.298	0.318	0.555	abundance	1530	865	0.00855	0.0165
Lacrimispora_amygdalina	antibiotics	Yes	antibioticsYes	-0.554	0.194	0.00428	0.0099	prevalence	1530	865	0.00855	0.0165
Eubacterium_ventriosum	reads	reads	reads	-0.305	0.117	1	1	abundance	1530	520	0.00859	0.0166
GGB16040_SGB9347	reads	reads	reads	-0.224	0.242	1	1	abundance	1530	114	0.0086	0.0166
Eubacterium_ventriosum	reads	reads	reads	0.165	0.0577	0.00431	0.00992	prevalence	1530	520	0.00859	0.0166
GGB16040_SGB9347	reads	reads	reads	0.288	0.101	0.00431	0.00992	prevalence	1530	114	0.0086	0.0166
Coprococcus_eutactus	antibiotics	Yes	antibioticsYes	-2.98	1.01	0.00432	0.0194	abundance	1530	177	0.00862	0.0166
Coprococcus_eutactus	antibiotics	Yes	antibioticsYes	-0.664	0.403	0.0993	0.156	prevalence	1530	177	0.00862	0.0166
Bifidobacterium_longum	diagnosis	CD	diagnosisCD	0.607	0.237	0.00441	0.0196	abundance	1530	843	0.0088	0.0169
Bifidobacterium_longum	diagnosis	CD	diagnosisCD	-0.298	0.14	0.0336	0.0618	prevalence	1530	843	0.0088	0.0169
GGB9453_SGB14844	reads	reads	reads	-0.928	0.204	0.00443	0.0196	abundance	1530	222	0.00883	0.0169
GGB9453_SGB14844	reads	reads	reads	0.00265	0.0748	0.972	0.979	prevalence	1530	222	0.00883	0.0169
GGB3277_SGB4327	diagnosis	UC	diagnosisUC	1.55	0.51	0.00446	0.0197	abundance	1530	152	0.00889	0.017
GGB3277_SGB4327	diagnosis	UC	diagnosisUC	0.152	0.225	0.5	0.599	prevalence	1530	152	0.00889	0.017
Prevotella_sp_885	antibiotics	Yes	antibioticsYes	-4.39	1.46	0.0045	0.0198	abundance	1530	69	0.00898	0.0171
Prevotella_sp_885	antibiotics	Yes	antibioticsYes	-0.0491	0.396	0.901	0.931	prevalence	1530	69	0.00898	0.0171
Roseburia_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.0606	0.852	0.586	0.894	abundance	1530	922	0.00942	0.0179
Roseburia_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.05	0.372	0.00472	0.0108	prevalence	1530	922	0.00942	0.0179
Bacteroides_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	5.21	1.7	0.00485	0.021	abundance	1530	434	0.00967	0.0184
Bacteroides_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.767	0.5	0.125	0.191	prevalence	1530	434	0.00967	0.0184
Ruminococcus_gnavus	reads	reads	reads	-0.599	0.101	0.0107	0.0405	abundance	1530	767	0.00978	0.0186
Ruminococcus_gnavus	reads	reads	reads	0.153	0.0544	0.0049	0.0112	prevalence	1530	767	0.00978	0.0186
GGB1680_SGB2312	diagnosis	UC	diagnosisUC	-2.93	1.14	0.00993	0.021	prevalence	1530	12	0.00993	0.0188
GGB3175_SGB4191	age	age	age	-0.118	0.264	1	1	abundance	1530	154	0.00996	0.0188
GGB3175_SGB4191	age	age	age	0.227	0.0809	0.00499	0.0113	prevalence	1530	154	0.00996	0.0188
Eubacterium_siraeum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.21	1.92	0.174	0.355	abundance	1530	565	0.01	0.0189
Eubacterium_siraeum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.69	0.603	0.00502	0.0114	prevalence	1530	565	0.01	0.0189
Escherichia_coli	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.719	0.619	0.61	0.922	abundance	1530	707	0.0101	0.019
Escherichia_coli	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.984	0.351	0.00505	0.0114	prevalence	1530	707	0.0101	0.019
Paraprevotella_clara	reads	reads	reads	0.189	0.24	0.028	0.0844	abundance	1530	178	0.0102	0.0193
Paraprevotella_clara	reads	reads	reads	0.223	0.0799	0.00514	0.0116	prevalence	1530	178	0.0102	0.0193
Flavonifractor_plautii	antibiotics	Yes	antibioticsYes	0.606	0.242	0.00517	0.0222	abundance	1530	1220	0.0103	0.0194
Flavonifractor_plautii	antibiotics	Yes	antibioticsYes	-0.239	0.216	0.268	0.36	prevalence	1530	1220	0.0103	0.0194
Clostridiales_bacterium	diagnosis	CD	diagnosisCD	0.23	0.179	0.096	0.224	abundance	1530	985	0.0105	0.0198
Clostridiales_bacterium	diagnosis	CD	diagnosisCD	-0.433	0.155	0.00529	0.0119	prevalence	1530	985	0.0105	0.0198
GGB3278_SGB4328	reads	reads	reads	-0.101	0.238	1	1	abundance	1530	179	0.0106	0.0199
GGB3278_SGB4328	reads	reads	reads	0.229	0.0823	0.00532	0.0119	prevalence	1530	179	0.0106	0.0199
Dialister_invisus	reads	reads	reads	-0.31	0.088	1	1	abundance	1530	726	0.0106	0.0199
Dialister_invisus	reads	reads	reads	0.153	0.0551	0.00533	0.0119	prevalence	1530	726	0.0106	0.0199
GGB781_SGB1024	diagnosis	CD	diagnosisCD	1.99	0.782	0.0111	0.0233	prevalence	1530	18	0.0111	0.0207
Clostridium_sp_1001270H_150608_G6	age	age	age	0.594	0.298	0.044	0.12	abundance	1530	141	0.0112	0.0208
GGB3304_SGB4367	diagnosis	CD	diagnosisCD	0.17	0.505	1	1	abundance	1530	155	0.0112	0.0208
Clostridium_sp_1001270H_150608_G6	age	age	age	0.232	0.0836	0.00562	0.0125	prevalence	1530	141	0.0112	0.0208
GGB3304_SGB4367	diagnosis	CD	diagnosisCD	-0.607	0.219	0.00562	0.0125	prevalence	1530	155	0.0112	0.0208
Lachnospira_sp_NSJ_43	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.11	1.85	0.119	0.267	abundance	1530	296	0.0117	0.0216
Lachnospira_sp_NSJ_43	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.9	0.688	0.00585	0.013	prevalence	1530	296	0.0117	0.0216
Bacteroides_fragilis	age	age	age	-0.0491	0.113	1	1	abundance	1530	787	0.012	0.0223
Bacteroides_fragilis	age	age	age	-0.147	0.0535	0.00603	0.0134	prevalence	1530	787	0.012	0.0223
Eubacterium_siraeum	reads	reads	reads	-0.755	0.15	0.0061	0.0256	abundance	1530	565	0.0122	0.0225
Eubacterium_siraeum	reads	reads	reads	0.154	0.058	0.00774	0.0168	prevalence	1530	565	0.0122	0.0225
GGB9713_SGB15249	reads	reads	reads	0.129	0.171	0.0063	0.0264	abundance	1530	329	0.0126	0.0232
GGB9713_SGB15249	reads	reads	reads	0.143	0.0683	0.0368	0.0666	prevalence	1530	329	0.0126	0.0232
Blautia_faecis	diagnosis	CD	diagnosisCD	0.406	0.175	0.0068	0.0283	abundance	1530	1120	0.0136	0.025
Blautia_faecis	diagnosis	CD	diagnosisCD	0.0798	0.161	0.621	0.705	prevalence	1530	1120	0.0136	0.025
Alistipes_SGB2313	diagnosis	UC	diagnosisUC	-2.2	0.817	0.00705	0.029	abundance	1530	73	0.0141	0.0258
Alistipes_SGB2313	diagnosis	UC	diagnosisUC	-0.588	0.31	0.0576	0.0982	prevalence	1530	73	0.0141	0.0258
Tyzzerella_nexilis	antibiotics	Yes	antibioticsYes	1.7	0.841	0.0369	0.105	abundance	1530	188	0.0141	0.026
Tyzzerella_nexilis	antibiotics	Yes	antibioticsYes	-0.918	0.341	0.0071	0.0157	prevalence	1530	188	0.0141	0.026
Haemophilus_parainfluenzae	reads	reads	reads	-0.63	0.107	0.0072	0.0293	abundance	1530	674	0.0144	0.0263
Haemophilus_parainfluenzae	reads	reads	reads	0.0457	0.0545	0.401	0.501	prevalence	1530	674	0.0144	0.0263
Eubacterium_ventriosum	diagnosis	UC	diagnosisUC	0.0724	0.274	1	1	abundance	1530	520	0.0145	0.0264
Eubacterium_ventriosum	diagnosis	UC	diagnosisUC	-0.39	0.145	0.00726	0.016	prevalence	1530	520	0.0145	0.0264
Rikenellaceae_bacterium	diagnosis	UC	diagnosisUC	-0.747	0.307	0.0149	0.0299	prevalence	1530	67	0.0149	0.0271
Ruminococcus_gnavus	antibiotics	Yes	antibioticsYes	-0.137	0.304	1	1	abundance	1530	767	0.0152	0.0277
Ruminococcus_gnavus	antibiotics	Yes	antibioticsYes	0.491	0.184	0.00763	0.0167	prevalence	1530	767	0.0152	0.0277
Bacteroides_caccae	age	age	age	-0.0856	0.0698	1	1	abundance	1530	958	0.0154	0.028
Proteus_mirabilis	diagnosis	UC	diagnosisUC	-1.02	1.02	0.288	0.51	abundance	1530	100	0.0154	0.028
Roseburia_hominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.46	0.791	0.183	0.372	abundance	1530	876	0.0154	0.028
Bacteroides_caccae	age	age	age	0.154	0.058	0.00774	0.0168	prevalence	1530	958	0.0154	0.028
Proteus_mirabilis	diagnosis	UC	diagnosisUC	-0.863	0.324	0.00775	0.0168	prevalence	1530	100	0.0154	0.028
Roseburia_hominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.998	0.375	0.00772	0.0168	prevalence	1530	876	0.0154	0.028
GGB1680_SGB2312	diagnosis	CD	diagnosisCD	-1.87	0.777	0.0159	0.0318	prevalence	1530	12	0.0159	0.0287
Eisenbergiella_massiliensis	diagnosis	UC	diagnosisUC	0.447	0.445	0.4	0.654	abundance	1530	417	0.016	0.0289
Eisenbergiella_massiliensis	diagnosis	UC	diagnosisUC	0.44	0.166	0.00802	0.0174	prevalence	1530	417	0.016	0.0289
Ruminococcus_sp_BSD2780120874_150323_B10	antibiotics	Yes	antibioticsYes	-2.11	0.876	0.0163	0.0325	prevalence	1530	90	0.0163	0.0293
Bacteroides_eggerthii	age	age	age	0.579	0.222	0.0082	0.0329	abundance	1530	409	0.0163	0.0294
Bacteroides_eggerthii	age	age	age	0.00796	0.0612	0.896	0.927	prevalence	1530	409	0.0163	0.0294
Coprococcus_eutactus	reads	reads	reads	0.246	0.22	0.00822	0.0329	abundance	1530	177	0.0164	0.0294
Coprococcus_eutactus	reads	reads	reads	0.0223	0.0883	0.801	0.846	prevalence	1530	177	0.0164	0.0294
Clostridium_leptum	diagnosis	UC	diagnosisUC	-0.118	0.257	1	1	abundance	1530	652	0.0168	0.0301
GGB51647_SGB4348	age	age	age	-0.914	0.337	0.00843	0.0334	abundance	1530	123	0.0168	0.0301
Clostridium_leptum	diagnosis	UC	diagnosisUC	-0.383	0.146	0.00844	0.0182	prevalence	1530	652	0.0168	0.0301
GGB51647_SGB4348	age	age	age	-0.174	0.1	0.0832	0.133	prevalence	1530	123	0.0168	0.0301
GGB1543_SGB2126	diagnosis	CD	diagnosisCD	-5.68	2.03	0.00887	0.0347	abundance	1530	42	0.0177	0.0316
GGB1543_SGB2126	diagnosis	CD	diagnosisCD	-0.898	0.417	0.0313	0.0583	prevalence	1530	42	0.0177	0.0316
GGB1549_SGB2133	diagnosis	UC	diagnosisUC	-1.23	1.13	0.256	0.466	abundance	1530	46	0.0178	0.0317
GGB1549_SGB2133	diagnosis	UC	diagnosisUC	-1.15	0.439	0.00892	0.0192	prevalence	1530	46	0.0178	0.0317
Coprococcus_comes	age	age	age	-0.213	0.0816	1	1	abundance	1530	759	0.0179	0.0319
Coprococcus_comes	age	age	age	-0.142	0.0545	0.00897	0.0193	prevalence	1530	759	0.0179	0.0319
Hungatella_hathewayi	reads	reads	reads	-0.751	0.156	0.00901	0.0351	abundance	1530	451	0.0179	0.0319
Hungatella_hathewayi	reads	reads	reads	0.117	0.057	0.0406	0.0724	prevalence	1530	451	0.0179	0.0319
Klebsiella_pneumoniae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	4.27	1.46	0.00915	0.0355	abundance	1530	119	0.0182	0.0324
Klebsiella_pneumoniae	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1	0.531	0.0597	0.101	prevalence	1530	119	0.0182	0.0324
GGB9480_SGB14874	reads	reads	reads	-0.331	0.125	1	1	abundance	1530	332	0.0188	0.0334
GGB9480_SGB14874	reads	reads	reads	0.17	0.0654	0.00945	0.0203	prevalence	1530	332	0.0188	0.0334
Alistipes_dispar	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	2.47	1.01	0.0095	0.0366	abundance	1530	83	0.0189	0.0335
Alistipes_dispar	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.745	0.361	0.039	0.07	prevalence	1530	83	0.0189	0.0335
Lachnospira_eligens	diagnosis	UC	diagnosisUC	0.644	0.22	0.00968	0.037	abundance	1530	929	0.0193	0.0341
Lachnospira_eligens	diagnosis	UC	diagnosisUC	0.114	0.159	0.474	0.574	prevalence	1530	929	0.0193	0.0341
Eisenbergiella_massiliensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	2.65	0.863	0.0097	0.037	abundance	1530	417	0.0193	0.0341
Eisenbergiella_massiliensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.261	0.347	0.453	0.556	prevalence	1530	417	0.0193	0.0341
Rikenellaceae_bacterium	age	age	age	0.26	0.111	0.0193	0.0379	prevalence	1530	67	0.0193	0.0341
Bacteroides_intestinalis	diagnosis	CD	diagnosisCD	-1.61	0.642	0.0179	0.0598	abundance	1530	158	0.0194	0.0341
Bacteroides_intestinalis	diagnosis	CD	diagnosisCD	0.575	0.223	0.00975	0.0209	prevalence	1530	158	0.0194	0.0341
GGB16040_SGB9347	diagnosis	CD	diagnosisCD	0.421	0.795	0.539	0.832	abundance	1530	114	0.0195	0.0342
GGB16040_SGB9347	diagnosis	CD	diagnosisCD	0.754	0.292	0.00978	0.0209	prevalence	1530	114	0.0195	0.0342
Bacteroides_uniformis	diagnosis	UC	diagnosisUC	0.286	0.186	1	1	abundance	1530	1240	0.0195	0.0342
Bacteroides_uniformis	diagnosis	UC	diagnosisUC	0.515	0.199	0.0098	0.0209	prevalence	1530	1240	0.0195	0.0342
Faecalibacterium_SGB15315	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.835	1.17	0.291	0.514	abundance	1530	619	0.0197	0.0344
Faecalibacterium_SGB15315	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.12	0.432	0.00988	0.021	prevalence	1530	619	0.0197	0.0344
Bifidobacterium_longum	antibiotics	Yes	antibioticsYes	0.773	0.361	0.0196	0.0641	abundance	1530	843	0.0198	0.0346
Bifidobacterium_longum	antibiotics	Yes	antibioticsYes	-0.481	0.187	0.00996	0.021	prevalence	1530	843	0.0198	0.0346
Blautia_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.871	0.483	0.334	0.577	abundance	1530	1120	0.0199	0.0347
Blautia_faecis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.908	0.353	0.01	0.0211	prevalence	1530	1120	0.0199	0.0347
Clostridium_symbiosum	antibiotics	Yes	antibioticsYes	0.892	0.375	0.0103	0.0391	abundance	1530	539	0.0205	0.0357
Clostridium_symbiosum	antibiotics	Yes	antibioticsYes	0.425	0.183	0.02	0.0388	prevalence	1530	539	0.0205	0.0357
Sutterella_wadsworthensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.14	0.946	0.438	0.702	abundance	1530	536	0.0213	0.0371
Sutterella_wadsworthensis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.36	0.533	0.0107	0.0225	prevalence	1530	536	0.0213	0.0371
Ruminococcus_lactaris	age	age	age	-0.376	0.143	0.011	0.0412	abundance	1530	379	0.0219	0.038
Ruminococcus_lactaris	age	age	age	0.109	0.0599	0.0694	0.114	prevalence	1530	379	0.0219	0.038
Roseburia_inulinivorans	age	age	age	-0.104	0.0816	1	1	abundance	1530	951	0.0222	0.0384
Roseburia_inulinivorans	age	age	age	-0.146	0.0576	0.0111	0.0233	prevalence	1530	951	0.0222	0.0384
GGB3175_SGB4191	reads	reads	reads	0.403	0.29	0.0114	0.042	abundance	1530	154	0.0227	0.0392
GGB3175_SGB4191	reads	reads	reads	0.171	0.0893	0.0558	0.0961	prevalence	1530	154	0.0227	0.0392
Roseburia_intestinalis	reads	reads	reads	-0.317	0.118	1	1	abundance	1530	842	0.0227	0.0392
Roseburia_intestinalis	reads	reads	reads	0.138	0.0546	0.0114	0.0238	prevalence	1530	842	0.0227	0.0392
GGB4237_SGB5728	reads	reads	reads	0.576	0.253	0.0228	0.0441	prevalence	1530	6	0.0228	0.0394
Bacteroides_cellulosilyticus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	4.22	1.51	0.0116	0.0426	abundance	1530	433	0.0231	0.0397
Bacteroides_cellulosilyticus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.19	0.536	0.0262	0.0496	prevalence	1530	433	0.0231	0.0397
Phocaeicola_dorei	diagnosis	UC	diagnosisUC	-0.192	0.506	0.601	0.91	abundance	1530	769	0.0235	0.0403
Phocaeicola_dorei	diagnosis	UC	diagnosisUC	0.383	0.152	0.0118	0.0246	prevalence	1530	769	0.0235	0.0403
Prevotella_stercorea	diagnosis	CD	diagnosisCD	1.73	0.772	0.025	0.0479	prevalence	1530	40	0.025	0.0429
Blautia_wexlerae	antibiotics	Yes	antibioticsYes	0.53	0.243	0.0132	0.0476	abundance	1530	1300	0.0262	0.0448
GGB3175_SGB4191	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.695	2.15	0.672	1	abundance	1530	154	0.0262	0.0448
Blautia_wexlerae	antibiotics	Yes	antibioticsYes	-0.499	0.226	0.0275	0.052	prevalence	1530	1300	0.0262	0.0448
GGB3175_SGB4191	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.71	0.688	0.0132	0.0273	prevalence	1530	154	0.0262	0.0448
Veillonella_dispar	antibiotics	Yes	antibioticsYes	0.351	0.527	0.422	0.685	abundance	1530	526	0.0266	0.0454
Veillonella_dispar	antibiotics	Yes	antibioticsYes	-0.519	0.21	0.0134	0.0276	prevalence	1530	526	0.0266	0.0454
GGB16040_SGB9347	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.877	1.99	0.741	1	abundance	1530	114	0.027	0.0459
Hungatella_hathewayi	diagnosis	UC	diagnosisUC	-0.954	0.414	0.0136	0.0486	abundance	1530	451	0.0269	0.0459
Phocaeicola_vulgatus	diagnosis	UC	diagnosisUC	0.405	0.261	0.203	0.397	abundance	1530	1290	0.027	0.0459
GGB16040_SGB9347	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-1.75	0.71	0.0136	0.0279	prevalence	1530	114	0.027	0.0459
Hungatella_hathewayi	diagnosis	UC	diagnosisUC	0.245	0.157	0.12	0.183	prevalence	1530	451	0.0269	0.0459
Phocaeicola_vulgatus	diagnosis	UC	diagnosisUC	0.602	0.244	0.0136	0.0279	prevalence	1530	1290	0.027	0.0459
Oscillibacter_sp_ER4	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.73	1.5	0.0376	0.107	abundance	1530	458	0.0272	0.0462
Oscillibacter_sp_ER4	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.77	0.72	0.0137	0.0281	prevalence	1530	458	0.0272	0.0462
Eubacterium_ventriosum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.674	0.962	0.263	0.474	abundance	1530	520	0.0275	0.0466
Eubacterium_ventriosum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.05	0.426	0.0138	0.0284	prevalence	1530	520	0.0275	0.0466
Ruthenibacterium_lactatiformans	antibiotics	Yes	antibioticsYes	-0.178	0.323	1	1	abundance	1530	797	0.0276	0.0466
Ruthenibacterium_lactatiformans	antibiotics	Yes	antibioticsYes	0.465	0.189	0.0139	0.0284	prevalence	1530	797	0.0276	0.0466
Coprococcus_comes	antibiotics	Yes	antibioticsYes	0.486	0.266	0.0362	0.104	abundance	1530	759	0.0278	0.047
Coprococcus_comes	antibiotics	Yes	antibioticsYes	0.482	0.196	0.014	0.0286	prevalence	1530	759	0.0278	0.047
Akkermansia_muciniphila	diagnosis	CD	diagnosisCD	-0.868	0.364	0.0289	0.0864	abundance	1530	407	0.0279	0.047
Akkermansia_muciniphila	diagnosis	CD	diagnosisCD	-0.357	0.145	0.014	0.0286	prevalence	1530	407	0.0279	0.047
Alistipes_finegoldii	diagnosis	CD	diagnosisCD	-0.0369	0.229	1	1	abundance	1530	639	0.0282	0.0473
Barnesiella_intestinihominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.44	1.78	0.112	0.254	abundance	1530	431	0.0282	0.0473
Fusicatenibacter_saccharivorans	diagnosis	CD	diagnosisCD	0.324	0.16	0.0142	0.0503	abundance	1530	1120	0.0282	0.0473
Alistipes_finegoldii	diagnosis	CD	diagnosisCD	-0.326	0.133	0.0142	0.0288	prevalence	1530	639	0.0282	0.0473
Barnesiella_intestinihominis	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.77	0.72	0.0142	0.0288	prevalence	1530	431	0.0282	0.0473
Fusicatenibacter_saccharivorans	diagnosis	CD	diagnosisCD	-0.253	0.184	0.169	0.246	prevalence	1530	1120	0.0282	0.0473
Roseburia_sp_AF02_12	antibiotics	Yes	antibioticsYes	-1.5	0.755	0.0597	0.156	abundance	1530	363	0.0291	0.0487
Roseburia_sp_AF02_12	antibiotics	Yes	antibioticsYes	-0.687	0.281	0.0146	0.0297	prevalence	1530	363	0.0291	0.0487
Bacteroides_eggerthii	antibiotics	Yes	antibioticsYes	-0.802	0.793	0.358	0.6	abundance	1530	409	0.0293	0.0491
Bacteroides_eggerthii	antibiotics	Yes	antibioticsYes	0.534	0.219	0.0148	0.0299	prevalence	1530	409	0.0293	0.0491
Faecalibacterium_SGB15346	antibiotics	Yes	antibioticsYes	-0.0726	0.382	1	1	abundance	1530	743	0.0295	0.0492
Faecalibacterium_SGB15346	antibiotics	Yes	antibioticsYes	-0.471	0.194	0.0149	0.0299	prevalence	1530	743	0.0295	0.0492
Eubacterium_ventriosum	age	age	age	-0.274	0.108	0.015	0.0527	abundance	1530	520	0.0298	0.0496
Eubacterium_ventriosum	age	age	age	0.0568	0.056	0.31	0.407	prevalence	1530	520	0.0298	0.0496
Ruminococcus_gnavus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.72	0.538	0.0151	0.0527	abundance	1530	767	0.0299	0.0497
Ruminococcus_gnavus	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.721	0.351	0.04	0.0715	prevalence	1530	767	0.0299	0.0497
Phocaeicola_massiliensis	age	age	age	-0.244	0.137	0.089	0.212	abundance	1530	396	0.0312	0.0519
Phocaeicola_massiliensis	age	age	age	0.141	0.0582	0.0157	0.0316	prevalence	1530	396	0.0312	0.0519
Roseburia_sp_AF02_12	age	age	age	0.327	0.139	0.0159	0.0546	abundance	1530	363	0.0316	0.0525
Roseburia_sp_AF02_12	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-2.83	1.08	0.016	0.0546	abundance	1530	363	0.0317	0.0525
Roseburia_sp_AF02_12	age	age	age	0.0663	0.0623	0.288	0.384	prevalence	1530	363	0.0316	0.0525
Roseburia_sp_AF02_12	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.82	0.382	0.0319	0.0594	prevalence	1530	363	0.0317	0.0525
Oscillibacter_sp_ER4	diagnosis	CD	diagnosisCD	0.339	0.24	0.0903	0.214	abundance	1530	458	0.0321	0.0531
Oscillibacter_sp_ER4	diagnosis	CD	diagnosisCD	-0.336	0.14	0.0162	0.0324	prevalence	1530	458	0.0321	0.0531
Ruminococcus_bromii	reads	reads	reads	-0.352	0.125	1	1	abundance	1530	429	0.0323	0.0534
Ruminococcus_bromii	reads	reads	reads	0.147	0.0614	0.0163	0.0325	prevalence	1530	429	0.0323	0.0534
Alistipes_dispar	diagnosis	CD	diagnosisCD	-1.48	0.576	0.0165	0.0557	abundance	1530	83	0.0327	0.0537
Collinsella_SGB14861	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.571	1.23	0.428	0.691	abundance	1530	593	0.0327	0.0537
Ruthenibacterium_lactatiformans	diagnosis	UC	diagnosisUC	-0.544	0.256	0.0164	0.0557	abundance	1530	797	0.0326	0.0537
Alistipes_dispar	diagnosis	CD	diagnosisCD	-0.429	0.283	0.13	0.198	prevalence	1530	83	0.0327	0.0537
Collinsella_SGB14861	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.28	0.533	0.0165	0.0328	prevalence	1530	593	0.0327	0.0537
Ruthenibacterium_lactatiformans	diagnosis	UC	diagnosisUC	-0.0819	0.147	0.578	0.667	prevalence	1530	797	0.0326	0.0537
Prevotella_copri_clade_E	diagnosis	CD	diagnosisCD	1.65	0.776	0.0329	0.061	prevalence	1530	38	0.0329	0.054
Prevotella_copri_clade_C	diagnosis	CD	diagnosisCD	2.3	1.08	0.033	0.0611	prevalence	1530	16	0.033	0.0541
Bacteroides_ilei	antibiotics	Yes	antibioticsYes	1.13	0.532	0.0331	0.0611	prevalence	1530	17	0.0331	0.0541
Lachnospira_pectinoschiza	diagnosis	UC	diagnosisUC	0.77	0.291	0.0167	0.0563	abundance	1530	500	0.0331	0.0541
Lachnospira_pectinoschiza	diagnosis	UC	diagnosisUC	-0.183	0.148	0.217	0.302	prevalence	1530	500	0.0331	0.0541
Faecalibacterium_SGB15346	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.637	0.784	0.185	0.373	abundance	1530	743	0.0333	0.0543
Faecalibacterium_SGB15346	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.866	0.362	0.0168	0.0334	prevalence	1530	743	0.0333	0.0543
Bacteroides_eggerthii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-2.82	2.36	0.173	0.355	abundance	1530	409	0.0334	0.0544
Bacteroides_eggerthii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.29	0.54	0.0168	0.0334	prevalence	1530	409	0.0334	0.0544
Clostridium_sp_AF36_4	reads	reads	reads	-0.0934	0.103	1	1	abundance	1530	568	0.035	0.057
Clostridium_sp_AF36_4	reads	reads	reads	0.137	0.0578	0.0177	0.035	prevalence	1530	568	0.035	0.057
Bacteroides_cellulosilyticus	reads	reads	reads	-0.281	0.149	1	1	abundance	1530	433	0.0358	0.0581
Eubacterium_rectale	diagnosis	CD	diagnosisCD	-0.458	0.165	0.0181	0.0598	abundance	1530	1210	0.0358	0.0581
Bacteroides_cellulosilyticus	reads	reads	reads	0.144	0.0609	0.0181	0.0357	prevalence	1530	433	0.0358	0.0581
Eubacterium_rectale	diagnosis	CD	diagnosisCD	-0.0705	0.195	0.718	0.784	prevalence	1530	1210	0.0358	0.0581
Oscillospiraceae_bacterium	reads	reads	reads	-0.283	0.287	1	1	abundance	1530	81	0.0364	0.0588
Oscillospiraceae_bacterium	reads	reads	reads	0.274	0.116	0.0183	0.0362	prevalence	1530	81	0.0364	0.0588
Faecalibacterium_SGB15346	age	age	age	-0.0229	0.0994	1	1	abundance	1530	743	0.0365	0.059
Faecalibacterium_SGB15346	age	age	age	0.129	0.0546	0.0184	0.0363	prevalence	1530	743	0.0365	0.059
Clostridiaceae_bacterium_Marseille_Q4149	reads	reads	reads	-0.376	0.232	1	1	abundance	1530	181	0.0389	0.0627
Clostridium_sp_AF36_4	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.212	0.886	0.487	0.765	abundance	1530	568	0.0389	0.0627
Clostridiaceae_bacterium_Marseille_Q4149	reads	reads	reads	0.187	0.0802	0.0197	0.0384	prevalence	1530	181	0.0389	0.0627
Clostridium_sp_AF36_4	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.06	0.455	0.0196	0.0384	prevalence	1530	568	0.0389	0.0627
Bacteroides_caccae	diagnosis	UC	diagnosisUC	0.103	0.188	1	1	abundance	1530	958	0.0394	0.0634
Bacteroides_caccae	diagnosis	UC	diagnosisUC	-0.358	0.154	0.0199	0.0388	prevalence	1530	958	0.0394	0.0634
Tyzzerella_nexilis	reads	reads	reads	-0.785	0.19	0.0205	0.0668	abundance	1530	188	0.0406	0.0651
Tyzzerella_nexilis	reads	reads	reads	0.00685	0.0803	0.932	0.952	prevalence	1530	188	0.0406	0.0651
Phascolarctobacterium_succinatutens	age	age	age	-0.328	0.135	0.0207	0.0671	abundance	1530	125	0.0409	0.0656
Phascolarctobacterium_succinatutens	age	age	age	0.036	0.09	0.689	0.761	prevalence	1530	125	0.0409	0.0656
Clostridium_sp_AM22_11AC	diagnosis	UC	diagnosisUC	0.621	0.237	0.0208	0.0675	abundance	1530	730	0.0413	0.0661
Clostridium_sp_AM22_11AC	diagnosis	UC	diagnosisUC	-0.102	0.145	0.483	0.582	prevalence	1530	730	0.0413	0.0661
Prevotella_SGB48271	diagnosis	UC	diagnosisUC	2.27	1.12	0.0422	0.075	prevalence	1530	6	0.0422	0.0675
Dysgonomonas_mossii	reads	reads	reads	-0.664	0.667	0.633	0.954	abundance	1530	31	0.0431	0.0688
Dysgonomonas_mossii	reads	reads	reads	-0.467	0.203	0.0218	0.0422	prevalence	1530	31	0.0431	0.0688
Phocaeicola_sartorii	age	age	age	0.301	0.135	0.0219	0.0701	abundance	1530	424	0.0433	0.069
Phocaeicola_sartorii	age	age	age	0.0264	0.0637	0.679	0.754	prevalence	1530	424	0.0433	0.069
GGB9480_SGB14874	antibiotics	Yes	antibioticsYes	-0.201	0.502	1	1	abundance	1530	332	0.0454	0.0723
GGB9480_SGB14874	antibiotics	Yes	antibioticsYes	-0.574	0.252	0.023	0.0443	prevalence	1530	332	0.0454	0.0723
Parasutterella_SGB9260	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-0.13	0.998	0.593	0.9	abundance	1530	269	0.0456	0.0724
Parasutterella_SGB9260	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.11	0.487	0.0231	0.0444	prevalence	1530	269	0.0456	0.0724
Ruminococcus_sp_BSD2780120874_150323_B10	reads	reads	reads	0.22	0.11	0.0459	0.0809	prevalence	1530	90	0.0459	0.0729
Ruminococcus_bicirculans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.48	0.537	0.194	0.384	abundance	1530	678	0.046	0.0729
Ruminococcus_bicirculans	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.541	0.238	0.0233	0.0448	prevalence	1530	678	0.046	0.0729
Faecalibacterium_SGB15346	diagnosis	CD	diagnosisCD	-0.63	0.247	0.0237	0.0751	abundance	1530	743	0.0468	0.074
Prevotella_copri_clade_A	antibiotics	Yes	antibioticsYes	-2.67	1.14	0.0237	0.0751	abundance	1530	289	0.0468	0.074
Faecalibacterium_SGB15346	diagnosis	CD	diagnosisCD	0.213	0.134	0.112	0.174	prevalence	1530	743	0.0468	0.074
Prevotella_copri_clade_A	antibiotics	Yes	antibioticsYes	-0.243	0.259	0.348	0.448	prevalence	1530	289	0.0468	0.074
Dysgonomonas_mossii	age	age	age	6.57	5.65	0.255	0.464	abundance	1530	31	0.0477	0.0752
Dysgonomonas_mossii	age	age	age	-0.5	0.222	0.0241	0.0463	prevalence	1530	31	0.0477	0.0752
Vescimonas_coprocola	age	age	age	-0.245	0.0962	1	1	abundance	1530	599	0.0497	0.0784
Vescimonas_coprocola	age	age	age	-0.128	0.0571	0.0252	0.0481	prevalence	1530	599	0.0497	0.0784
Tyzzerella_nexilis	age	age	age	-0.146	0.197	1	1	abundance	1530	188	0.0505	0.0793
Bacteroides_ilei	diagnosis	UC	diagnosisUC	2.16	1.1	0.0505	0.0881	prevalence	1530	17	0.0505	0.0793
Tyzzerella_nexilis	age	age	age	-0.195	0.0874	0.0256	0.0488	prevalence	1530	188	0.0505	0.0793
Lachnospira_sp_NSJ_43	reads	reads	reads	-0.736	0.176	0.0256	0.0798	abundance	1530	296	0.0506	0.0794
Lachnospira_sp_NSJ_43	reads	reads	reads	0.00084	0.0735	0.991	0.993	prevalence	1530	296	0.0506	0.0794
Enterocloster_bolteae	antibiotics	Yes	antibioticsYes	0.618	0.309	0.0257	0.0798	abundance	1530	866	0.0507	0.0795
Enterocloster_bolteae	antibiotics	Yes	antibioticsYes	0.0381	0.181	0.833	0.872	prevalence	1530	866	0.0507	0.0795
Dysosmobacter_sp_BX15	age	age	age	0.0536	0.0813	1	1	abundance	1530	621	0.0508	0.0795
Tyzzerella_nexilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.507	0.633	0.253	0.463	abundance	1530	188	0.0509	0.0795
Dysosmobacter_sp_BX15	age	age	age	0.122	0.0548	0.0257	0.049	prevalence	1530	621	0.0508	0.0795
Tyzzerella_nexilis	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	0.612	0.275	0.0258	0.049	prevalence	1530	188	0.0509	0.0795
Dialister_invisus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.271	0.374	1	1	abundance	1530	726	0.0513	0.0798
Dialister_invisus	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-0.49	0.22	0.026	0.0493	prevalence	1530	726	0.0513	0.0798
GGB33512_SGB15201	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.75	1.93	0.0512	0.0892	prevalence	1530	121	0.0512	0.0798
Ruminococcus_gnavus	diagnosis	CD	diagnosisCD	0.0516	0.266	1	1	abundance	1530	767	0.0531	0.0825
Ruminococcus_gnavus	diagnosis	CD	diagnosisCD	0.299	0.135	0.0269	0.0508	prevalence	1530	767	0.0531	0.0825
GGB9342_SGB14306	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.72	1.93	0.054	0.0934	prevalence	1530	92	0.054	0.0838
Hungatella_hathewayi	antibiotics	Yes	antibioticsYes	1.01	0.49	0.0276	0.084	abundance	1530	451	0.0544	0.0843
Hungatella_hathewayi	antibiotics	Yes	antibioticsYes	-0.12	0.194	0.536	0.629	prevalence	1530	451	0.0544	0.0843
Clostridium_sp_1001270H_150608_G6	reads	reads	reads	0.258	0.269	0.0276	0.084	abundance	1530	141	0.0545	0.0843
Clostridium_sp_1001270H_150608_G6	reads	reads	reads	0.0647	0.097	0.505	0.603	prevalence	1530	141	0.0545	0.0843
GGB9453_SGB14844	antibiotics	Yes	antibioticsYes	-0.698	0.632	0.323	0.561	abundance	1530	222	0.0547	0.0845
Parabacteroides_distasonis	antibiotics	Yes	antibioticsYes	0.38	0.205	0.0278	0.0842	abundance	1530	1140	0.0548	0.0845
GGB9453_SGB14844	antibiotics	Yes	antibioticsYes	0.509	0.231	0.0277	0.0523	prevalence	1530	222	0.0547	0.0845
Parabacteroides_distasonis	antibiotics	Yes	antibioticsYes	0.155	0.216	0.472	0.573	prevalence	1530	1140	0.0548	0.0845
Bilophila_wadsworthia	antibiotics	Yes	antibioticsYes	0.289	0.315	0.251	0.462	abundance	1530	764	0.056	0.0864
Bilophila_wadsworthia	antibiotics	Yes	antibioticsYes	-0.427	0.195	0.0284	0.0535	prevalence	1530	764	0.056	0.0864
Bacteroides_mediterraneensis	diagnosis	CD	diagnosisCD	-1.27	0.665	0.0564	0.097	prevalence	1530	13	0.0564	0.0868
Bacteroides_ilei	diagnosis	CD	diagnosisCD	2.07	1.09	0.0579	0.0986	prevalence	1530	17	0.0579	0.089
Ruminococcus_bromii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.99	1.71	0.732	1	abundance	1530	429	0.0581	0.0892
Ruminococcus_bromii	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	-1.57	0.721	0.0295	0.0552	prevalence	1530	429	0.0581	0.0892
Butyrivibrio_crossotus	antibiotics	Yes	antibioticsYes	1.04	0.554	0.0598	0.101	prevalence	1530	43	0.0598	0.0916
Parasutterella_SGB9260	age	age	age	0.256	0.123	0.0305	0.0902	abundance	1530	269	0.06	0.0918
Parasutterella_SGB9260	age	age	age	-0.127	0.0722	0.0777	0.125	prevalence	1530	269	0.06	0.0918
GGB781_SGB1024	reads	reads	reads	0.368	0.196	0.0602	0.101	prevalence	1530	18	0.0602	0.0919
Ruminococcus_sp_BSD2780120874_150323_B10	dysbiosis_state	dysbiosis_CD	dysbiosis_statedysbiosis_CD	-3.61	1.92	0.0609	0.102	prevalence	1530	90	0.0609	0.0929
GGB3277_SGB4327	reads	reads	reads	0.095	0.201	0.0312	0.0918	abundance	1530	152	0.0615	0.0936
GGB3277_SGB4327	reads	reads	reads	0.127	0.0852	0.137	0.207	prevalence	1530	152	0.0615	0.0936
Bacteroides_caccae	reads	reads	reads	-0.243	0.0705	1	1	abundance	1530	958	0.0647	0.0984
Bacteroides_caccae	reads	reads	reads	0.123	0.0578	0.0329	0.061	prevalence	1530	958	0.0647	0.0984
Clostridium_symbiosum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	1.71	0.609	0.033	0.0957	abundance	1530	539	0.0649	0.0985
Clostridium_symbiosum	dysbiosis_state	dysbiosis_UC	dysbiosis_statedysbiosis_UC	0.115	0.329	0.728	0.79	prevalence	1530	539	0.0649	0.0985
Phocaeicola_massiliensis	reads	reads	reads	-0.213	0.149	1	1	abundance	1530	396	0.0652	0.0989
Phocaeicola_massiliensis	reads	reads	reads	0.13	0.0608	0.0332	0.0612	prevalence	1530	396	0.0652	0.0989
Eubacterium_siraeum	antibiotics	Yes	antibioticsYes	0.473	0.457	0.233	0.438	abundance	1530	565	0.0654	0.0991
Eubacterium_siraeum	antibiotics	Yes	antibioticsYes	0.414	0.194	0.0333	0.0613	prevalence	1530	565	0.0654	0.0991

Full output file structure

MaAsLin 3 generates two types of output files: data and visualization.

Data output files
- significant_results.tsv
  - Described above.
- all_results.tsv
  - Same format as above but for all associations and with an extra column listing any errors from the model fitting.
- features
  - This folder includes the filtered, normalized, and transformed versions of the input feature table.
  - These steps are performed sequentially in the above order.
  - If an option is set such that a step does not change the data, the resulting table will still be output.
- models_LM.rds and models_logistic.rds
  - This file contains a list with every model fit object (LM for linear models, logistic for logistic models).
  - It will only be generated if save_models is set to TRUE.
- residuals_LM.rds and residuals_logstic.rds
  - This file contains a data frame with residuals for each feature.
- fitted_LM.rds and fitted_logistic.rds
  - This file contains a data frame with fitted values for each feature.
- ranef_LM.rds and ranef_logistic.rds
  - This file contains a data frame with extracted random effects for each feature (when random effects are specified).
- maaslin3.log
  - This file contains all log information for the run.
  - It includes all settings, warnings, errors, and steps run.
Visualization output files
- summary_plot.pdf
  - This file contains a combined coefficient plot and heatmap of the most significant associations. In the heatmap, one star indicates the individual q-value is below the parameter max_significance, and two stars indicate the individual q-value is below max_significance divided by 10.

## [1] TRUE

* association_plots/[metadatum]_[feature]_[association].pdf * A plot is generated for each significant association up to max_pngs. * Scatter plots are used for continuous metadata abundance associations. * Box plots are used for categorical data abundance associations. * Box plots are used for continuous data prevalence associations. * Grids are used for categorical data prevalence associations. * Data points plotted are after filtering, normalization, and transformation so that the scale in the plot is the scale that was used in fitting.

The four types of association plots

At the top right of each association plot is the name of the significant association in the results file, the FDR corrected q-value for the individual association, the number of samples in the dataset, and the number of samples with non-zero abundances for the feature. In the plots with categorical metadata variables, the reference category is on the left, and the significant q-values and coefficients in the top right are in the order of the values specified above. Because the displayed coefficients correspond to the full fit model with (possibly) scaled metadata variables, the marginal association plotted might not match the coefficient displayed. However, the plots are intended to provide an interpretable visual while usually agreeing with the full model.

Diagnostics

There are a few common issues to check for in the results:

When warnings or errors are thrown during the fitting process, they are recorded in the error column of all_results.tsv. Often, these indicate model fitting failures or poor fits that should not be trusted, but sometimes the warnings can be benign, and the model fit might still be reasonable. Users should check associations of interest if they produce errors.
Despite the error checking, significant results could still result from poor model fits. These can usually be diagnosed with the visuals in the association_plots directory.
- Any significant abundance associations with a categorical variable should usually have at least 10 observations in each category.
- Significant categorical prevalence associations should also have at least 10 samples in which the feature was present and at least 10 samples in which it was absent for each significant category.
- Significant abundance associations with continuous metadata should be checked visually for influential outliers.

Replotting

Once maaslin3 has been run once, maaslin_plot_results_from_output can be run with the same param_list as the original maaslin3 run to (re-)create the plots. This allows the user to plot the associations even without having the R object returned by maaslin_fit or maaslin3 (e.g., if fitting models through the command line). It is recommended to fit models with simple variables names that are robust to formula plotting and then convert these into proper names for plotting. Likewise, heatmap_vars and coef_plot_vars can be specified in the param_list at any point, but it is usually easier to see how the names come out at first and then choose which metadata variables will go in the coefficient plot and which will go in the heatmap afterwards with maaslin_plot_results_from_output.

# This section is necessary for updating the summary plot and the association plots

# Rename results file with clean titles
all_results <- read.csv('demo_output/all_results.tsv', sep='\t')
all_results <- all_results %>%
  mutate(metadata = case_when(metadata == 'age' ~ 'Age',
                              metadata == 'antibiotics' ~ 'Abx',
                              metadata == 'diagnosis' ~ 'Diagnosis',
                              metadata == 'dysbiosis_state' ~ 'Dysbiosis',
                              metadata == 'reads' ~ 'Read depth'),
         value = case_when(value == 'dysbiosis_CD' ~ 'CD',
                           value == 'dysbiosis_UC' ~ 'UC',
                           value == 'Yes' ~ 'Used', # Antibiotics
                           value == 'age' ~ 'Age',
                           value == 'reads' ~ 'Read depth',
                           TRUE ~ value),
         feature = gsub('_', ' ', feature) %>% 
           gsub(pattern = 'sp ', replacement = 'sp. '))

# Write results
write.table(all_results, 'demo_output/all_results.tsv', sep='\t')

# Set the new heatmap and coefficient plot variables and order them
param_list$heatmap_vars = c('Dysbiosis UC', 'Diagnosis UC', 'Abx Used', 'Age', 'Read depth')
param_list$coef_plot_vars = c('Dysbiosis CD', 'Diagnosis CD')

# This section is necessary for updating the association plots
colnames(param_list$input_data) <- gsub('_', ' ', colnames(param_list$input_data)) %>%
  gsub(pattern = 'sp ', replacement = 'sp. ')

# Rename the features in the norm transformed data file
filtered_data_norm_transformed <- 
  read.csv('demo_output/features/filtered_data_norm_transformed.tsv', sep='\t')
colnames(filtered_data_norm_transformed) <- 
  gsub('_', ' ', colnames(filtered_data_norm_transformed)) %>%
  gsub(pattern = 'sp ', replacement = 'sp. ')
write.table(filtered_data_norm_transformed, 
            'demo_output/features/filtered_data_norm_transformed.tsv', 
            sep='\t', row.names = F)

# Rename the metadata like in the outputs table
colnames(param_list$input_metadata) <- 
  case_when(colnames(param_list$input_metadata) == 'age' ~ 'Age',
            colnames(param_list$input_metadata) == 'antibiotics' ~ 'Abx',
            colnames(param_list$input_metadata) == 'diagnosis' ~ 'Diagnosis',
            colnames(param_list$input_metadata) == 'dysbiosis_state' ~ 'Dysbiosis',
            colnames(param_list$input_metadata) == 'reads' ~ 'Read depth',
            TRUE ~ colnames(param_list$input_metadata))
param_list$input_metadata <- param_list$input_metadata %>%
  mutate(Dysbiosis = case_when(Dysbiosis == 'dysbiosis_UC' ~ 'UC',
                               Dysbiosis == 'dysbiosis_CD' ~ 'CD',
                               Dysbiosis == 'none' ~ 'None') %>%
           factor(levels = c('None', 'UC', 'CD')),
         Abx = case_when(Abx == 'Yes' ~ 'Used',
                         Abx == 'No' ~ 'Not used') %>%
           factor(levels = c('Not used', 'Used')),
         Diagnosis = case_when(Diagnosis == 'nonIBD' ~ 'non-IBD',
                               TRUE ~ Diagnosis) %>%
           factor(levels = c('non-IBD', 'UC', 'CD')))

# Recreate the plots
scatter_plots <- maaslin_plot_results_from_output(param_list)

In the new summary plot below, we can see that the feature names are cleaned up, the metadata names are cleaned up, the set of metadata variables used in the coefficient plot is different, and the metadata used in the heatmap is reordered.

In the association plots, the taxa and metadata have been renamed to be consistent with the results file from earlier.

The four types of association plots

4. Advanced Topics

4.1 Interactions

df_input_metadata$CD_dysbiosis = (df_input_metadata$diagnosis == "CD") *
                                 df_input_metadata$dysbiosis
df_input_metadata$UC_dysbiosis = (df_input_metadata$diagnosis == "UC") *
                                 df_input_metadata$dysbiosis

fit_data_ixn = Maaslin2(input_data     = df_input_data, 
                        input_metadata = df_input_metadata, 
                        min_prevalence = 0,
                        normalization  = "NONE",
                        output         = "demo_output_interaction", 
                        fixed_effects  = c("diagnosis", "dysbiosis", "CD_dysbiosis", "UC_dysbiosis"), 
                        reference      = c("diagnosis,nonIBD"))

4.2 Random Effects

Certain studies have a natural “grouping” of sample observations, such as by subject in longitudinal designs or by family in family designs. It is important for statistic analysis to address the non-independence between samples belonging to the same group MaAsLin 3 provides a simple interface for this through the parameter random_effects, where the user can specify the grouping variable to run a mixed effect model instead. For example, we note that HMP2 is a longitudinal design where the same subject (column subject) can have multiple samples. We thus ask MaAsLin 3 to use subject as its random effect grouping variable:

fit_data_random = Maaslin2(input_data     = df_input_data, 
                           input_metadata = df_input_metadata, 
                           min_prevalence = 0,
                           normalization  = "NONE",
                           output         = "demo_output_random", 
                           fixed_effects  = c("diagnosis", "dysbiosis"),
                           random_effects = c("subject"),
                           reference      = c("diagnosis,nonIBD"))

If you are interested in testing the effect of time in a longitudinal study, then the time point variable should be included in fixed_effects during your MaAsLin 3 call.

Question: intuitively, can you think of a reason why it is important to address non-independence between samples?
- Hint: imagine the simple scenario where you have two subject, one case and one control, each has two samples.
- What is the effective sample size, when samples of the same subject are highly independent, versus when they are highly correlated?

4.3 Additional Options

MaAsLin 3 provide many parameter options for different data pre-processing (normalization, filtering, transfomation) and other tasks. The full list of these options are:

min_abundance
- The minimum abundance for each feature [ Default: 0 ]
min_prevalence
- The minimum percent of samples for which a feature is detected at minimum abundance [ Default: 0.1 ]
max_significance
- The q-value threshold for significance [ Default: 0.25 ]
normalization
- The normalization method to apply [ Default: "TSS" ] [ Choices: "TSS", "CLR", "CSS", "NONE", "TMM" ]
transform
- The transform to apply [ Default: "LOG" ] [ Choices: "LOG", "LOGIT", "AST", "NONE" ]
analysis_method
- The analysis method to apply [ Default: "LM" ] [ Choices: "LM", "CPLM", "ZICP", "NEGBIN", "ZINB" ]
correction
- The correction method for computing the q-value [ Default: "BH" ]
standardize
- Apply z-score so continuous metadata are on the same scale [ Default: TRUE ]
plot_heatmap
- Generate a heatmap for the significant associations [ Default: TRUE ]
heatmap_first_n
- In heatmap, plot top N features with significant associations [ Default: 50 ]
plot_scatter
- Generate scatter plots for the significant associations [ Default: TRUE ]
cores
- The number of R processes to run in parallel [ Default: 1 ]
reference
- The factor to use as a reference for a variable with more than two levels provided as a string of ‘variable,reference’ semi-colon delimited for multiple variables.

4.3.1 Prevalence and abundance filtering in MaAsLin 3

Typically, it only makes sense to test for feature-metadata associations if a feature is non-zero “enough” of the time. “Enough” can vary between studies, but a 10-50% minimum prevalence threshold is not unusual (and up to 70-90% can be reasonable). Since we’re already using a small, selected subset of demo data, we’ll use min_prevalence = 0.1 to test only features with at least 10% non-zero values. Note: this is the default parameter setting in MaAsLin 3.

Similarly, it’s often desirable to test only features that reach a minimum abundance threshold in at least this many samples. By default, MaAsLin 3 will consider any non-zero value to be reliable, and if you’ve already done sufficient QC in your dataset, this is appropriate. However, if you’d like to filter more or be conservative, you can set a minimum abundance threshold like min_abundance = 0.0001 to test only features reaching at least this (relative) abundance.

Putting these arguments together, we can run MaAsLin 3 (and it’ll go even faster!) using both:

fit_data_filter = Maaslin2(input_data     = df_input_data, 
                           input_metadata = df_input_metadata, 
                           normalization  = "NONE",
                           output         = "demo_output_filter", 
                           fixed_effects  = c("diagnosis", "dysbiosis"),
                           reference      = c("diagnosis,nonIBD"),
                           random_effects = c("subject"),
                           min_prevalence = 0.1,
                           min_abundance  = 0.0001)

5. Command Line Interface

MaAsLin 3 can also be run with a command line interface. For example, the demo analysis can be performed with:

Maaslin2.R --transform=AST --fixed_effects="diagnosis,dysbiosis"  /usr/local/lib/R/site-library/Maaslin2/extdata/HMP2_taxonomy.tsv /usr/local/lib/R/site-library/Maaslin2/extdata/HMP2_metadata.tsv demo_output --reference="diagnosis,nonIBD"

Make sure to provide the full path to the MaAsLin 3 executable (ie ./R/Maaslin2.R).
In the demo command:
- HMP2_taxonomy.tsv is the path to your data (or features) file
- HMP2_metadata.tsv is the path to your metadata file
- demo_output is the path to the folder to write the output

Full help documentation:

$ Maaslin2.R --help
Usage: ./R/Maaslin2.R [options] <data.tsv> <metadata.tsv> <output_folder>

Options:
    -h, --help
        Show this help message and exit

    -a MIN_ABUNDANCE, --min_abundance=MIN_ABUNDANCE
        The minimum abundance for each feature [ Default: 0 ]

    -p MIN_PREVALENCE, --min_prevalence=MIN_PREVALENCE
        The minimum percent of samples for which a feature 
        is detected at minimum abundance [ Default: 0.1 ]

    -s MAX_SIGNIFICANCE, --max_significance=MAX_SIGNIFICANCE
        The q-value threshold for significance [ Default: 0.25 ]

    -n NORMALIZATION, --normalization=NORMALIZATION
        The normalization method to apply [ Default: TSS ]
        [ Choices: TSS, CLR, CSS, NONE, TMM ]

    -t TRANSFORM, --transform=TRANSFORM
        The transform to apply [ Default: LOG ]
        [ Choices: LOG, LOGIT, AST, NONE ]

    -m ANALYSIS_METHOD, --analysis_method=ANALYSIS_METHOD
        The analysis method to apply [ Default: LM ]
        [ Choices: LM, CPLM, NEGBIN, ZINB ]

    -r RANDOM_EFFECTS, --random_effects=RANDOM_EFFECTS
        The random effects for the model, comma-delimited
        for multiple effects [ Default: none ]

    -f FIXED_EFFECTS, --fixed_effects=FIXED_EFFECTS
        The fixed effects for the model, comma-delimited
        for multiple effects [ Default: all ]

    -c CORRECTION, --correction=CORRECTION
        The correction method for computing the 
        q-value [ Default: BH ]

    -z STANDARDIZE, --standardize=STANDARDIZE
        Apply z-score so continuous metadata are 
        on the same scale [ Default: TRUE ]

    -l PLOT_HEATMAP, --plot_heatmap=PLOT_HEATMAP
        Generate a heatmap for the significant 
        associations [ Default: TRUE ]

    -i HEATMAP_FIRST_N, --heatmap_first_n=HEATMAP_FIRST_N
        In heatmap, plot top N features with significant 
        associations [ Default: TRUE ]

    -o PLOT_SCATTER, --plot_scatter=PLOT_SCATTER
        Generate scatter plots for the significant
        associations [ Default: TRUE ]

    -e CORES, --cores=CORES
        The number of R processes to run in parallel
        [ Default: 1 ]

    -r REFERENCE, --reference='VARIABLE,REFERENCE'
        The factor to use as a reference for a 
        variable with more than two levels 
        provided as a string of 'variable,reference' 
        semi-colon delimited for multiple variables.